Intranet Čeština

Biomaterials and Tissue Engineering

Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

•          To improve currently-used synthetic tissue replacements by introducing cell and other biological components

•          To construct completely new replacements on the basis of synthetic materials and cells

To achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More

Publications

Vaněk, Přemysl - Kolská, Z. - Luxbacher, T. - García, J.A.L. - Lehocký, M. - Vandrovcová, Marta - Bačáková, Lucie - Petzelt, Jan . Electrical activity of ferroelectric biomaterials and its effects on the adhesion, growth and enzymatic activity of human osteoblast-like cells . Journal of Physics D-Applied Physics. 2016, roč. 49, 17, p. 175403 . IF = 2.772 [ASEP] [ doi ]
Rabyk, Mariia - Hrubý, Martin - Vetrík, Miroslav - Kučka, Jan - Proks, Vladimír - Pařízek, Martin - Konefal, Rafal - Krist, Pavel - Chvátil, David - Bačáková, Lucie - Šlouf, Miroslav - Štěpánek, Petr . Modified glycogen as construction material for functional biomimetic microfibers . Carbohydrate Polymers. 2016, roč. 152, 5 November, p. 271-279 . IF = 4.219 [ASEP] [ doi ]
Moravec, H. - Vandrovcová, Marta - Chotová, K. - Fojt, J. - Průchová, E. - Joska, L. - Bačáková, Lucie . Cell interaction with modified nanotubes formed on titanium alloy Ti-6Al-4V . Materials Science & Engineering C-Materials for Biological Applications. 2016, roč. 65, Aug 1, p. 313-322 . IF = 3.420 [ASEP] [ doi ]
Krátká, Marie - Babchenko, Oleg - Ukraintsev, Egor - Vachelová, Jana - Davídková, Marie - Vandrovcová, Marta - Kromka, Alexander - Rezek, Bohuslav . Gamma radiation effects on hydrogen-terminated nanocrystalline diamond bio-transistors . Diamond and Related Materials. 2016, roč. 63, Mar, 186-191 . IF = 2.125 [ASEP] [ doi ]
Jelínek, Miroslav - Zemek, Josef - Vandrovcová, Marta - Bačáková, Lucie - Kocourek, Tomáš - Remsa, Jan - Písařík, Petr . Bonding and bio-properties of hybrid laser/magnetron Cr-enriched DLC layers . Materials Science & Engineering C-Materials for Biological Applications. 2016, roč. 58, Jan, p. 1217-1224 . IF = 3.420 [ASEP] [ doi ]

Article photogallery

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Biomaterials and Tissue Engineering

Vídeňská 1083
14220 Prague 4
tel. +420 241 063 743
 

lucy@biomed.cas.cz

Lucie.Bacakova@fgu.cas.cz

People

Doc. MUDr. Lucie Bačáková, CSc.
head of the department

RNDr. Marta Vandrovcová, Ph.D.
deputy head of the department

Doc. MUDr. Vladislav Mareš, DrSc.
emeritus researcher

MUDr. Jaroslav Chlupáč, Ph.D.
researcher

Mgr. Elena Filová, Ph.D.
researcher
Ing. Ondřej Kaplan, Ph.D.
researcher
Věra Lisá, prom. biol.
researcher
Mgr. Jana Lišková, Ph.D.
researcher (maternity leave)
RNDr. Jana Musílková, CSc.
researcher
RNDr. Lubica Staňková (née. Grausová), Ph.D.
researcher (maternity leave)
Ing. Markéta Bačáková, Ph.D.
postdoctoral researcher
MUDr. Jaroslav Chlupáč, Ph.D.
researcher
Mgr. Ivana Kopová, Ph.D.
postdoctoral researcher
RNDr. Martin Pařízek​, Ph.D.
postdoctoral researcher
Mgr. Martin Plencner, Ph.D.
postdoctoral researcher
Ing. Jana Zárubová (née. Havlíková), Ph.D.

postdoctoral researcher
Mgr. Antonín Brož
PhD student
Mgr. Nikola Kročilová 
PhD student
Mgr. Radmila Kudláčková 
PhD student

Mgr. Júlia Pajorová
PhD student

Mgr. Marie Steinerová
PhD student
Mgr. Júlia Pajorová
PhD student

MUDr. Martina Trávníčková
PhD student

Martina Doubková
pregraduate student
Helena Dragounová
pregraduate student
Anežka Marko
pregraduate student
Jana Voborníková
administrative worker
Mgr. Jarmila Knitlová
technician biologist
Ivana Zajanová
technician

© 2014 INSTITUTE OF PHYSIOLOGY CAS