Intranet Čeština

Molecular Neurobiology

Molecular Neurobiology Left: Growth and arborization of peripheral nerves in E12.5 embryos stained with anti neurofilament antibodies. Right: 3D collagen co-cultures. Dorsal root ganglia axon repulsion assays in control (C) and semaphorin3A (S3A) gradient.

Defects in signaling cascades are considered to contribute to many neurodevelopmental and neurodegenerative disorders, but the exact molecular mechanisms underlying the onset of these diseases are so far largely unknown. We focus on identification of genes, molecular mechanism and signaling cascades that regulate neuron polarization, axonal/dendritic growth and guidance in the developing nervous system, and contribute to the pathogenesis of neurodegenerative disorders when deregulated in terminally differentiated neurons.

Our work focuses on:

  • the role of Pin1 catalyzed isomerization of microtubule associated proteins in axon/dendrite development
  • the effect of protein isomerization on axon regeneration
  • changes in phosphorylation and conformation of microtubule associated proteins in neurodegeneration



Balaštík, Martin - Zhou, X.Z. - Alberich-Jorda, M. - Weissová, Romana - Žiak, Jakub - Pazyra-Murphy, M.F. - Cosker, K.E. - Machoňová, O. - Kozmiková, I. - Chen, CH. - Pastorino, L. - Asara, J.M. - Cole, A. - Sutherland, C. - Segal, R. A. - Lu, K.P. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons . Cell Reports. 2015, Vol. 13, 4, p. 812-828 . IF = 7.87 [ASEP] [ doi ]

Article photogallery


Institute of Physiology AS CR, v.v.i.
Department of Molecular Neurobiology

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 822


  Martin Balaštík, Ph.D.
head of the department
  Mgr. Romana Weissová
PhD student/deputy head of department

Mgr. Barbora Eliášová

PhD student

  Mgr. Marie Kleisnerová
PhD student
  MUDr. Jakub Žiak
PhD student