LECTURE "The role of mitochondrial uncoupling proteins and phospholipase iPLA2γ in the regulation of cellular redox homeostasis"
Redox-dependent regulations play an essential role in a wide range of biological activities. Mitochondria in numerous tissues represent a major source of superoxide and subsequent downstream oxidants, notably H2O2 and lipid hydroperoxides. Results from our laboratory have shown that the mitochondrial uncoupling protein 2 (UCP2) plays an antioxidant role in various tissues by a mechanism involving redox – sensitive Ca2+-independent phospholipase A2γ (iPLA2γ). In this lecture, I will summarize our current understanding of the mechanism of iPLA2γ-dependent, uncoupling protein – mediated feedback regulation of cellular redox homeostasis, and discuss recent advances in the antioxidant and signaling actions of phospholipase iPLA2γ in selected physiological situations.