Intranet
Campus web
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Core Facilities
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Further info on Ultracentrifuges, Rotors, and Tubes
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Important success
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Clock in the choroid plexus in the brain are sensitive to disruption of the daily regime but resistant to inflammatory conditions
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Junior Research Group Leader
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Invitation to the lecture " Maternal Milk - White Gold"
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PhD programme
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Pain Research
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ABOUT THE INSTITUTE
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Do not forget about Alzheimer's disease
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70 years of the Institute of Physiology of the CAS
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Brain Week begins!
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Day of Physiology and Medicine for Undergraduate Students 2024
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A Day of Physiology and Medicine for Undergraduate Students - 24.2.2022
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Day of Physiology and Medicine for Undergraduate Students (22.2.2024)
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Day of Physiology and Medicine for Undergraduate Students (22.2.2023)
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New publication (IF=15): Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption. Brain Behav Immun (2024)
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Jaroslava Folbergrová has died
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Open Science
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Mgr./Bc. positions
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Excelentní výzkum v regenerativní medicíně (2023 - 2028)
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The ability to transport K+ cations and hence the physiological role of Na+/H+ antiporters is influenced by the composition of their hydrophilic C-termini
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International Advisory Board of Institute of Physiology CAS
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Přehled poskytnutých informací
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Information provided by law
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PhD positions
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National Institute for Neurological Research (NPO-NEURO-D) (2022-2025)
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A new method for quantification of information transmission reliability between neurons
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Metabolism
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Centres of Excellence
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Contact HR
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Program - A Day of Physiology and Medicine for Undergraduate Students 2024
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Cations - key elements for life of eukaryotic cells
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Study of transporters involved in multidrug resistance in Candida yeasts
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Research projects
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How does 14-3-3 protein block CaMKK protein kinase activity?
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BIOCEV-Krč Methodological Seminars
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The results of the best IPHYS publication competition for year 2022
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Effect of microbiome on local extraadrenal corticosteroid metabolism in the intestine and secondary lymphoid organs
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Local metabolism of glucocorticoids and intestinal inflammation
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Regulation of intestinal transport
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Effect of gut microbiota and sex on neuroendocrine regulatory pathways during stress
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Přednášky v roce 2023
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Competition for the best IPHYS publication
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Two IPHYS principal investigators were successful in the competition of Ministry of Education, Youth and Sports Inter-Excellence II USA
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Job vacancies
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Lectures 2024
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The human body in health and disease
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Train your brain (not only) during Brain Awareness Week!
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Ondrej Kuda received Prize of Minister of Education 2023
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Awards
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Ondřej Kuda received Prize of Minister of Education
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Alexandra Ptáková received the Rector's Award for Outstanding Scientific Achievement within the Charles University Grant Agency support
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Helena Illnerová in the documentary series Babylon
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Burn your fat!
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Institute Management
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Contact IP
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Prof. RNDr. Helena Illnerová, DrSc.
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Jan KOPECKÝ, M.D., D.Sc.
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Czech-BioImaging
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Risk factors for cardiovascular and metabolic diseases are associated with misaligned sleep schedules
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Metabolomics, lipidomics and fluxomics
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Annual reports
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Structure-activity guided design of novel long-acting antagonists of muscarinic receptors
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Proteomic laboratory
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Molecular Neuroendocrinology
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Insights into the operational model of agonism of receptor dimers
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Functionally selective and biased agonists of muscarinic receptors.
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Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors.
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Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptors
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How do the cells gain enough potassium?
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PhD study subjects 2
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Lectures 2022
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Cell cation and pH homeostasis
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Special techniques to estimate cell physiological parameters
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Transporters of pathogenic yeasts and lipid composition of their membranes as targets for new antifungal drugs
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Transporters reflected in specific properties of nonconventional yeasts
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Analysis of the molecular mechanisms underlying hemodynamic abnormalities that initiate the development of hypertension with increased salt intake
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Analysis of the hemodynamic mechanisms of the development of salt sensitive hypertension in hyperaldosteronism
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Linkage and correlation analyses of intermediary phenotypes to reveal candidate genes underlying complex pathophysiological traits in the SHR strain
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Publication
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Our latest publications
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New pulblication (IF=6.3): Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules. Sleep (2023)
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New publication (IF=7.4): Lithium affects the circadian clock in the choroid plexus – A new role for an old mechanism. Biomedicine & Pharmacotherapy (2023)
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Press release: Heat from skeletal muscle can protect not only against cold but also against obesity
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Heat from skeletal muscle can protect not only against cold but also against obesity
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Facts and Figures
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Study of metabolic and cardiovascular diseases within project CarDia
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Role of UCP1-independent non-shivering thermogenesis in cold- and obesity-resistance
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Changes of transcriptome during early postnatal development in humans: impact of premature birth on control of energy metabolism
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The role of impaired autophagy and peroxisome function in NAFLD development and their recovery for improved efficacy of omega-3 supplementation
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Novel approaches to enhance insulin-sensitizing effects of exercise: targeting PAHSA metabolism (ETAPA)
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Physiological relevance of white adipose tissue plasticity and its relationship to the development of obesity and to thermogenic response (closed project)
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FGF21 effects on adipose tissue metabolism and their importance for treatment of metabolic syndrome (concluded project)
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About the Institute
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The role of intestine in the metabolic effects of dietary supplementation with omega-3 fatty acids (concluded project)
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The role of the endocannabinoid system in metabolic effects of marine omega-3 phospholipids (concluded project)
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The effect of exercise training and omega-3 supplementation on metabolic parameters and lipidome in elderly women (concluded project)
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Glutamate receptor research
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TRP channel research
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Functional effects of human disease-associated NMDAR gene mutations
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Molecular mechanisms of TRPC5 ion channel activation and regulation
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Mechanisms of thermosensation in ThermoTRP channels
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NMDAR modulation by neurosteroids and membrane lipids
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Press release: Take a pill in the morning or in the evening? Lithium affects the brain differently depending on the time of day.
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Take a pill in the morning or in the evening? The mood stabilizer lithium affects the brain differently depending on the time of day
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Program - A Day of Physiology and Medicine for Undergraduate Students 2023
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National Institute for Metabolic and Cardiovascular Disease Research (CarDia) (2022 – 2025)
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FGÚ MSCA Mobilita IV (2020 - 2023)
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NERVOUS SYSTEM AND BRAIN RESEARCH
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Heat or cold? New insights into the functioning of temperature-sensitive ion channels obtained in collaboration with Lund University
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Bureš lectures in 2023
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Preclinical testing of potential pharmaceuticals (2017-2023)
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Heat, or cold? New insights of the functioning of temperature-sensitive ion channels may open the way for a new medicines development
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Josef Zicha was granted by the Jan Evangelista Purkinje Medal for the achievements in biomedical sciences (2020)
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Jaroslav Kuneš was granted by the Gregor Johann Mendel Medal for the achievements in natural sciences (2018)
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Characterizaton of the interactions between transcription factor FOXO4 and tumour supressor p53
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Structural basis of the 14-3-3 protein-dependent activation of ubiquitin ligase Nedd4-2
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New publication (IF=9.6): Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach. Greiner P, Houdek P, Sládek M, Sumová A (2022) PLoS Biol 20(5): e3001637.
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Characterization of novel antidiabetic drug with less side effects on bone metabolism
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The structure of steroids fundamentally affects their effect at the N-methyl-D-aspartate receptors
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Developmental Epileptology - annotation
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Pain Research - annotation
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Kateryna Semenovykh received the Martina Roeselová Foundation Grant
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Four important IPHYS researchers celebrated their life anniversaries
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The results of the best IPHYS publication competition for year 2021
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New lipid classes in human breastmilk
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Akce pro veřejnost
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Results of bibliometric analysis of M17+
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Bureš lectures in 2018
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External meeting of Ph.D. students
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Veronika Palůchová received the Josef Hlávka Prize
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Great first place for student Martin Kubeš, who completed his internship within the Open Science project at IPHYS
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Branched fatty acid esters of hydroxy fatty acids (FAHFA)
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Unravelling novel regulatory mechanisms in the human Na+/H+ antiporter NHA2
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Vojtěch Vyklický was successful in the JUNIOR STAR project announced by GA CR
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Lucie Bačáková received the prestigious Academic Award - Praemium Academiae 2022
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Photo gallery of student external meeting
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Visit of the International Advisory Board in the Institute of Physiology
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2nd Bilateral meeting with the Nencki Institute of the Polish Academy of Sciences in Warsaw
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Program
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Partners of the event
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Book of Abstracts
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Maternal rhythmic behavior supports the development of the fetal biological clock
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Ion channel TRPC5 as a target for treating neuropathic pain
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New findings on the structure of the FOXO4: p53 complex - a key factor in senescence regulation
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Enrico Patrono won the national round of the international competition Falling Walls Lab
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Michal Pravenec received G. J. Mendel Honorary Field Medal
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Organizational Structure
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Effect of preterm and caesarean births on breast milk quality
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SUMMER COURSE FOR MEDICAL STUDENTS 2022
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Kurz pro VŠ studenty biologických oborů
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Otto Wichterle prize
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Czech institutions join together to fight the epidemic of obesity, diabetes and heart disease. They got a billion of EU money to do it.
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Maternal daily rhythmic behavior supports the development of the fetal biological clock
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Dalibor Košek received Otto Wichterle Prize
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PHD PROGRAMME 2022
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13th BIOCEV-Krč Methodological Seminar
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Přemysl Jiruška received the Award of the Minister of Health
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Metabolomics atlas of a mouse
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New publication (IF=9.3): Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks. Honzlová P, Z Novosadová, P Houdek, M Sládek and A Sumová. Cell Mol Life Sci 2022 May 27;79(6):318
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New publication: Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus. Sladek, Liska, Houdek, Sumová. Neuropharmacology 185 (2021)
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Secondary School Expert Activity (SOČ)
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MediAim – New Therapeutic and Drug Development Strategies
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Advancement Report - 2022
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12th BIOCEV-Krč Methodological Seminar
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NEW FINDINGS ON THE STRUCTURE OF THE FOXO4: p53 COMPLEX - A KEY FACTOR IN SENESCENCE REGULATION (9.4.2022)
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Scientists have described the interaction of important proteins that are key to cell aging
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QUALITAS - Wellbeing in health and disease (2015-2021)
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Qualitas media coverage
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Qualitas activities
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Centre for Preclinical Testing (CPT)
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Train your brain (not only) during Brain Awareness Week!
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Gender Equality Plan
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Awarding of J. E. Purkyne medals and celebration of the 70th anniversary of the Physiological Research Journal
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Poskytování informací dle zákona č. 106/1999 Sb., o svobodném přístupu k informacím
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Discover the world of physiology online!
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Discover the world of physiology online!
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Contact popularization
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Ion channels and electrical excitability of pituitary cells
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Neurosteroids: positive and negative allosteric P2X receptor modulators
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Purinergic signalling in the suprachiasmatic and supraoptic nucleus of the hypothalamus
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Personalizovaná medicína – diagnostika a terapie (2019 - 2022)
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Program - A Day of Physiology and Medicine for Undergraduate Students
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Doctor´s committee for DSc.
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Chillies cause the pain but also can reduce it
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Our new paper: Role of transmembrane domains in P2X7 receptor activation and sensitization
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Our new paper: CRH-induced excitability in pituitary corticotrophs
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Our new paper: Allosteric modulation of P2X4 receptor channel conductivity.
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Our new paper: Ivermectin action on ligand-gated ion channels
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Organization of satellite symposium NEUROINFLAMATION to the regional FENS meeting in Prague (2013)
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Chemotherapy induced neuropathic pain
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Inhibition effect of NAPE at spinal cord level
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The role of PAR2 receptors in modulation of nociceptive signalling at the spinal cord level
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The role of spinal TRPV1 receptors in CCL2-induced hyperalgesia
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Modulation of synaptic transmission in oxytocin- and vasopressin-containing neurons
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Allosteric binding sites and gating properties of purinergic P2X receptors
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F.A.Q.- Ph.D.
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František Vyskočil received the Silver Medal of Charles University
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QX200 Droplet Digital PCR System
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Prof. RNDr. Aleš Stuchlík, DSc.
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Jan Kopecký received J. E. Purkinje Honorary Field Medal
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The effectivity of opioid analgesics is reduced by CCL2 chemokine
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Gliflozins - more than just antidiabetics
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Postdoctoral students lectures
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Qualitas contact
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Prof. RNDr. František Vyskočil, DrSc.
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Important Personalities of IPHYS
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Advancement Report
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Master's and Bachelor's Studies
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Alena Sumová was appointed a Professor
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Our new articles in Communications Biology
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Petr Ježek received the Prize of Minister of Education
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Targeted modulation of NMDA receptors is a key for the effective treatment of neurological and neurodevelopmental diseases
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IPHYS internships come top among secondary-school students
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Six scientists of the Institute of Physiology belong among 2% of the most cited authors in the world
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Almost a fifth of the lecturers at the Open Science Conference 2021 did their internship at IPHYS
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Patents
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The results of the best IPHYS publication competition for year 2020
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Jak dobře znáte lidské tělo?
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Omega-3 polyunsaturated fatty acids
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Structural basis of heat-induced opening of TRP channels
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Martina Trávníčková received the Scientific Award of the French Embassy
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František Vyskočil received the Medal of the Faculty of Science of Charles University
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Helena Illnerová received the Silver Medal of the President of the Senate
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Jste skřivan nebo sova?
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Kdo má nejrychlejší tepovou frekvenci na světě?
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Které jídlo je zdravé a kolik cukru obsahuje?
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Odkud mozek ovládá vaše svaly?
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Vyluštíte vědeckou tajenku?
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Publications
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HR Excellence in Research Award
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Action plan
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About the project
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New findings may help to improve diagnostic methods for breast cancer
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Michaela Tencerová succeeded in the competition L'Oréal-UNESCO For Women in Science
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Prof. Radovan H. Žák, M.D., Ph. D. (1931-1999)
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Prof. MUDr. Tomáš Radil, DrSc.
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MUDr. Jan Bureš, DrSc.
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Ladislav Vyklický, M.D., D.Sc.
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RNDr. Tomáš Soukup CSc.
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Prof. Zdeněk Servít and his work at IPHYS
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Prof. Zdeněk Servít, M.D., D.Sc.
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Prof. MUDr. Otakar Poupa, DrSc.
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Doc. RNDr. Petr Lánský, DrSc.
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Prof. Jiří KŘEČEK, M.D., D.Sc.
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Arnošt Kotyk
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Prof. Arnošt Gutmann and his work at IPHYS
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Prof. MUDr. Arnošt Gutmann, DrSc.
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Dr. Jan Bureš and his work at IPHYS
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Qualitas topics
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Prof. Tomáš Radil has died
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SUMMER COURSE FOR MEDICAL STUDENTS 2021
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Nanocellulose as a promising cell carrier for applications in regenerative medicine
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OBK Services
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Institute evaluation
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Institutional info brochure 2020
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History and present
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Articles about the history of the Institute
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OBK Contact
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Gerta Vrbová
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Stanislav Tuček
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Jiří Pařízek
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Otakar Koldovský
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Olga Hudlická
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Pavel Hník
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Peter Hahn
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Zdeněk Deyl
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Prof. MUDr. Bohuslav Ošťádal, DrSc.
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Hematological testing of blood / plasma / serum from test animals
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Directors of the Institute
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Publications
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Memory Park´s psychological tests attracted over 1200 people
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7 scientists from the Institute of Physiology are among the 2% most cited scientists in the world
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Jakub Otáhal was appointed a Professor
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Publications 2015 - 2021
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Molecular mechanisms of functional selectivity of atypical agonists at muscarinic receptors
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Molecular mechanisms of signalling bias at muscarinic receptors
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Cholinergic modulation of striatum-based behaviour
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Molecular mechanisms of membrane cholesterol effects on function of muscarinic receptors
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Palmitoylation controls NMDA receptor susceptibility to neurosteroids
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Clove oil alleviates cold-induced toothache by blocking the TRPC5 ion channel
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Petr Lánský has died
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Opioid receptors and drug addiction
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The effect of monovalent ions on delta-opioid receptors – analysis of lithium effect in living cells and isolated cell membranes
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The role of cell membrane and membrane domains
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Biochemistry of Membrane Receptors
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OPT Scanner
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Confocal microscope Leica SPE
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Bruker Ultima IntraVital
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µPET/CT Albira
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Carv II system
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Leica SP8 WLL MP laser scanning confocal microscope with supercontinuum “white light” laser and multiphoton excitation
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SPIM – Selective Plane Illumination Microscope
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CellVizio Dual Band
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Nanotechnology helps in the development of advanced bone implants
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More information
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IPHYS internships are the most popular among high school students!
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Prof. Tomáš Radil´s Memoirs
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Michaela Tencerová obtained the prestigious grant
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Eva Zažímalová visited the Institute of Physiology
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Pavel Mareš received the Medal of the Czech Medical Association
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The Best IPHYS Publication Awards
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8th February - International Epilepsy Day
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PhD theses
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Defended theses
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Open science
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František Vyskočil received Prize of the President of The Czech Academy of Sciences for the research popularization
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Barbora Heřmanovská won the Student Scientific Conference of Medical Faculties
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Fyziologický ústav patří k nejúspěšnějším žadatelům v projektu výzkumné spolupráce s USA
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Tchajwan delegation is interested in the topic of biomaterials and tissue engineering
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Institute of Physiology presentation during Week of Science and Technology 2018
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Secondary School Students
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Courses
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2021
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Study programme and benefits
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Tomáš Čajka is a co-author of the unique software for analyses of complex lipids in biological samples
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The results of the best IPHYS publication competition for year 2018
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Physiological Research
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About the programme Qualitas
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Partners
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Antidiabetic lipid mediators as neutral lipase substrates
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Mitochondrial cardiolipin in adipose tissue as a novel target for treatment of cardiac cachexia
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Antioxidants and their possible use for epilepsy treatment
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Anti-epileptic drug gabapentin decreases blood pressure through the attenuation of sympathetic nerve transmission
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Alignment of mother and offspring body clock could prevent diseases such as heart disease and obesity
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The effect of gut microbiome on expression of genes involved in regulation of stress response in chronic stress
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Small amounts of inorganic nitrate or beetroot provide substantial protection from salt-induced Increases in blood pressure
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A promising pharmacological approach in cardiovascular disease prevention
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The resistance of pancreatic beta cells to oxidative stress, which accompanies diabetes type 2, can be increased by mitochondria-targeted antioxidants
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Transcription factor Hif-1a is required for the correct development of the sympathetic nervous system and innervation of the heart
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Innovative method of the Forhkead transcription factor FOXO3 regulation
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Elucidation of TRPA1 activation mechanisms may help to understand the pathophysiology of chronic pain
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Lipokine 5-PAHSA is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for de novo Lipogenesis in Mice
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Signalling bias as the way to side-effect-free medication
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Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel-induced peripheral neuropathy
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Novel mechanism of insulin secretion highlights the importance of redox signalization
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Dietary supplementation with Krill oil as a novel strategy to improve insulin sensitivity and reduce liver fat accumulation in obesity
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Neurosteroid pregnenolone sulfate - revealing of its site of action at the N-methyl-D-aspartate receptor
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Publications - Laboratory of Cellular and Molecular Neuroendocrinology (2008 - 2019)
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Utility models
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European research consortium LipiDiDiet finds long-lasting and broadly benefiting effects of nutritional intervention in early Alzheimer’s
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15th International Conference on Endothelin organized in Prague in 2017
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Obesity, type 2 diabetes and neurodegeneration crosstalk: New therapeutic potential of prolactin-releasing peptide analogs
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Participation in project "Otevřená věda"
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The operational model of allosteric modulation of pharmacological agonism
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Novel M<sub>2</sub>-Selective, Gi-Biased Agonists of Muscarinic Acetylcholine Receptors
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Agonist-specific conformations of the M<sub>2</sub> muscarinic acetylcholine receptor assessed by molecular dynamics
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11th BIOCEV-Krč Methodological Seminar
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Protein analysis for the third millennium (2020-2022)
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Barrande Fellowship Program 2020 - Internship grant in category Life Sciences and Medicine
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Czech Science Foundation grant awarded
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Zdeněk Drahota and Alena Sumová Awarded Honorary Medals of the Czech Academy of Sciences
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Chemoinformatics resources
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Neuroscience
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Disorders of Biorhythms
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Chronic Heart Failure
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Obesity and Metabolic Syndrome
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Type 2 Diabetes
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Inherited Metabolic Disorders
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Muscle Atrophy
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Cancer
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Yeast Infection (Candidosis)
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Hypertension
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Ischemic Heart Disease
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Cardiac Arrhythmias
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Epilepsy
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Schizophrenia
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Depression
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Neuropathic Pain
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Alzheimer's Disease
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Bone Marrow Diseases
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CARDIOVASCULAR SYSTEM RESEARCH
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METABOLISM RESEARCH
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Ondřej Kuda won “Lumina Quaeruntur praemium”
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Effects of omega-3 in type 2 diabetic patients – new mechanisms for targeted therapy (concluded project)
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Enhancing energy expenditure in white adipose tissue by combination treatments using omega-3 and calorie restriction (concluded project)
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Involvement of the adiponectin-AMPK axis in insulin-sensitizing effects of thiazolidinediones (colncluded project)
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Modified lignin as a potential new food supplement with antioxidant effects (concluded project)
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Metabolism of eicosanoids in adipose tissue: molecular mechanisms with respect to fatty acid substrate (concluded project)
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Our laboratory as a partner in EU projects
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List of publications before 2007
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Dr. Jan Kopecký won a special prize awarded by the Minister of Education, Youth and Sports
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Our articles repeatedly on the list of the most significant results of Czech Academy of Sciences
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Our articles among the most cited works of the Institute of Physiology
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Two workers from our department won Otto Wichterle Award
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PHD PROGRAMME 2020 - CALL FOR APPLICATIONS
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Vojtěch Kumpošt Awarded the Prize of the Ministry of Education, Youth and Sports
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Metabolomics 2.0
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Innovative method of the Forhkead transcription factor FOXO3 regulation
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František Kolář awarded the Jan Evangelista Purkinje Honorary Field Medal
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Institute of Physiology Welcomes Taiwanese Organization ITRI
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Excellent Student Results in the Project "Open Science 2019"
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Martin Zápotocký Elected the Vice-president of the Organization for Computational Neurosciences
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Ladislav Vyklický Awarded the Prize of the Minister of Health
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The Power List 2018 -- The Fab Forty
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Cardiovascular Physiology
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Research Topics
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The results of the best IPHYS publication competition for year 2017
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PhD student conference 2019
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Bureš lecture series
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Anti-inflammatory effects of novel lipokines of fatty acid esters of hydroxy fatty acids (FAHFA) family in obesity
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Euro-BioImaging joins European Research Infrastructure Consortium (ERIC)
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Local installation of MetaboAnalyst
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Lectures 2019
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PharmaBrain (2018 - 2022)
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Rozvoj HR kapacit, internacionalizace, popularizace a využití IP (2018 - 2022)
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CRediT generator
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RNDr. Lucie Kubínová, CSc.
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RNDr. Jaroslav KUNEŠ, D.Sc.
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Prof. Pavel Mareš, M.D., D.Sc.
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RNDr. Zdeněk Drahota, D.Sc.
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Winners of the 41st annual contest of Students’ Professional Activities announced
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Jaroslav Kuneš awarded the Mendel Medal
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Jan Kudláček awarded the Sanofi Prize
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65th ANNIVERSARY OF THE FOUNDING OF THE INSTITUTE OF PHYSIOLOGY
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SECOND SEMINAR OF THE JOINT PRECLINICAL AND CLINICAL RESEARCH INITIATIVE IN IKEM AND IPHYS
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THE NATURE INDEX: CAS AMONG THE TOP GOVERNMENT INSTITUTIONS IN BIOMEDICAL SCIENCES
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TRPV1 and TRPA1 as intrinsically voltage-sensitive ion channels
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Molecular mechanisms of thermosensation
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Genetic variants of NMDA receptor genes in schizophrenia patients
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Modulation of NMDA receptors by neurosteroids
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Synaptic effects and neuroprotective properties of NMDA receptor modulators
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Influence of membrane lipids on NMDA receptor function
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Contact
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Contact
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Institute of Physiology of the CAS received HR Excellence in Research Award
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Beetroot provide substantial protection from salt-induced increases in blood pressure
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The end of alternation between standard time and summer time
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Correctly administered aid for epileptic seizure is easy and may save lives
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Scientists and engineers join the Motol Hospital to treat epilepsy in a newly established EPIREC research center
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Epileptic seizures do not come as a bolt from the blue
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Ondřej Kuda received The Lumina Quaeruntur award
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The Week of the Brain 2019
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Martina Doubková received the Werner von Siemens Award
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100 scientists in secondary schools
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Memory Park captivated visitors of the Week of the Brain
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OPPK NeuroImage (2010)
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OP VVV Mezinárodní mobility MSCA – IF II (2019 - 2021)
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Intellectual Property
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Technology Transfer
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Applications and limitations of fitting of the operational model to determine relative efficacies of agonists
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Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline
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Novel long-acting antagonists of muscarinic ACh receptors
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Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes
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n-3 PUFA differentially modulate adipose tissue endocannabinoid levels and glucose metabolism in obese mice and type 2 diabetic subjects
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Elucidation of molecular basis of 14-3-3 protein-dependent activation of trehalase Nth1 in yeast cells
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Anti-inflammatory effects of novel lipokines of fatty acid esters of hydroxy fatty acids family in obesity
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The role of antioxidant defense in the synthesis of antidiabetic lipokines
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Lumina quaeruntur 2018
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Prekliniky contact
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About the programme
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Prekliniky media coverage
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Prekliniky topics
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Prekliniky activities
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Advancement Report - 2019
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Role of Brain Angiotensin II, Nitric Oxide and Reactive Oxygen Species in Blood Pressure Control: The Importance in Contrasting Forms of Hypertension
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Complex analysis of protective actions of empagliflozin on metabolic parameters and cardiorenal damage in experimental non-diabetic Hypertension
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Central and peripheral modulation of vascular tone and sodium excretion: the role of brain and kidney in pathophysiology of hypertension
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Uncovering of signaling pathway regulating changes in energy metabolism during development of pulmonary hypertension
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IPHYS CAS applies for HR Award
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Advancement Report - 2017
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New diagnostic approaches to mitochondrial diseases
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The best publication in Physiological Research with the young authors for the year 2018
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The best publication with the authors from IP for the year 2017
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Sensor domain of TRPA1 channel contributes to detection of painful stimuli
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Tomáš Čajka among TOP 40 best scientists under 40 years
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The scientific evidence indicates that installing ‘wintertime’ is the best option for public health
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Lecture "Hypertension and chronic kidney disease - causes and consequences" invitation
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Lectures 2018
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Clinical research poster award for David Kala
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FGU Mobilita (2018 - 2020)
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Tvorba nových neuronů v dospělém mozku
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Hipokampus a jeho funkce
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Obsedantně kompulzivní porucha
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Prostorová navigace
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Integration of molecular, cellular and systems approaches in study of cognitive functions
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Barbora Heřmanovská won at the Student Scientific Conference of 1st Faculty of Medicine
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40th national show of the Secondary professional activity project
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The recorded interest in the fellowship of Open science programme. IPHYS was among the top five most requested!
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IPHYS presentation at Science Fair 2018
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Aleš Stuchlík received the degree of Doctor of Science
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Science Fair 2018
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IPHYS received a grant PharmaBrain
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New Frontiers in Basic Cardiovascular Research 2018
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IPHYS received a grant in Horizont 2020 programme
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H2020 EPTRI (2018 - 2019)
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Science Fair
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Metabolomics in Clinical Research
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Axon zippering and its control by tension forces
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Correlation between resistance to obesity and lipid synthesis in adipose tissue
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Cellular and molecular basis of memory
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Podpora profesního růstu (2017 - 2020)
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Brain Awareness Week 2018
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The Czech and Slovak Academy of Sciences have concluded a cooperation agreement
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Reportage Czech Science 02/2018
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Student "Velemlok" Prize 2017 gained team of teachers from IPHYS
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Memory park at Brain Awareness Week
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Reconstruction and registration of images acquired by multimodal preclinical imaging methods
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Přemysl Jiruška was appointed a professor
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Oxidative stress and its consequences
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Prolactin-releasing peptide: a new tool for obesity treatment
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TMEM70 disease
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Role of Plzf gene in regulation of metabolic and cardiac traits
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Awarded Professorships
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Image analysis of biological microscopic data for measurement of fibrous microscopic structures
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Modulation of microtubule dynamics by nanosecond electric pulses
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Advancement Report - 2018
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IOCB Prague and Institute of Physiology have signed license agreement with Novo Nordisk
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Stress-induced modulation of baroreflex sensitivity in spontaneously hypertensive rats: the role of renin-angiotensin system and glucocorticoids
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Bilateral Mobility Project with Polish Academy of Sciences
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Calmodulin and protein S100A1 bind in distal N- terminus of TRPM4 channel
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Advancement of phase-contrast microscopy (Neuromethods 2018)
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Microscopic “optical-staining” strategies to visualize living cells
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Pre-Christmas celebration
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Photogenic science 2017 knows its winners. And it´s also the IPHYS representative!
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Helena Illnerová received the Josef Hlávka Medal
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The results of the best IPHYS publication competition for year 2016
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The memory of Prof. Aronšt Gutmann
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Mitochondria´a role in heart damage due to myocardial infarction
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Mitochondria dysfunction and Fanconi syndrome
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Our picture among winners of a photo contest "Věda fotogenická"
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Lecture "Memory, aging and Alzheimer's disease"
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Our new paper in PNAS
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Our new paper in JBC: Structural Insight into the 14-3-3 Protein-Dependent Inhibition of Protein Kinase ASK1.
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Our new publication in Journal of Biological Chemistry: Role of the EF-hand-like Motif in the 14-3-3 Protein-mediated Activation of Yeast Neutral Trehalase Nth1.
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THE NENCKI INSTITUTE AND INSTITUTE OF PHYSIOLOGY 1ST CONFERENCE IN PRAGUE
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Opening course in physiological methods for beginner students
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Bureš lectures in 2017
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Obituary RNDr. Tomáš Soukup, CSc.
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Elucidating cardiac conduction system formation with phylogenetic approach
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President of the CAS visited Institute of Physiology
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Cancer cachexia can reflect aberrant metabolism of adipose tissue
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IPHYS stand at the Science Fair 2017
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International poster award (Innsbruck 2016)
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Sexual dimorphism in pheasant brains (Scientific Reports 2015)
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Invited review on confocal stereology (Cell & Tissue Research 2015)
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Capillary length estimation (Microscopy & Microanalysis 2013)
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Response of forest tree species to elevated carbon dioxide concentration: Chloroplast ultrastructure
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Konfokální mikroskop Leica SP2 AOBS
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The Centre for Preclinical Testing (CPT) commenced activities
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Lectures 2017
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February 8 - International Epilepsy Day
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Czech-BioImaging project
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The new findings revealing coupling of mitochondrial structure and function
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Mgr. Salome Kylarová
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RNDr. Miroslava Alblová, Ph.D.
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RNDr. Veronika Obšilová, Ph.D.
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What can we do about lifestyle diseases? A meeting of experts from IKEM and the Institute of Physiology CAS
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Cenu MUDr. Jana Bureše za rok 2016 získal RNDr. Vojtěch Vyklický, Ph.D.
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The memorandum of cooperation between the Czech Academy of Sciences and Royal Vinohrady Teaching Hospital
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Lecture "Sleep, health and biological clock"
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Circadian clock and mechanisms of entrainment
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Development of the cardiac conduction system in mice
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Developmental modularity of the brain in the evolution of bird locomotion
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postdoc position - GPDH
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Postdoc position - DAPIT
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Week brain
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Physiological and molecular changes during the progression cardiac failure
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Consequences of early brain-damage and prevention of development of epilepsy and functional damage
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Impact of seizures on the developing brain
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Consequences of brain injury during early stages of the brain development
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Impact of antiepileptic therapy on the brain development
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A new model of obsessive-compulsive disorder (OCD)
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Chairman of the Polish Academy of Sciences Jerzy Duszynski visited Prague
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Structural motifs within the TRPA1 receptor contribute to detection of painful stimuli
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Czech - U.S. international cooperation in research and development
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Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
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Ladislav Vyklický was appointed a Professor
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Hana Elicharová získala pamětní grant M. Roeselové
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Veřejné sbírka k získání peněžitých prostředků na pomoc rodině Pavla Flachse
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Anti-inflammatory effects of omega-3 PUFA are mediated by new lipid mediators from adipose tissue
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Why some people have dental caries?
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Ivana Vaněčková received the degree of Doctor of Science
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The memorandum of cooperation between Na Homolce Hospital and The Czech Academy of Sciences
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Advancement Report - autumn 2016
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The results of the best IPHYS publication competition for year 2015
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Successfull presentation at 26th International Meeting of International Society of Hypertension in Seoul
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Michal Behuliak was granted by the director of the Institute of Physiology the Young Investigator award for authors under 35 years
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Michal Behuliak was granted by the general manager of Servier the Young Investigator award
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Otto Wichterle prize was granted to Mgr. Michal Behuliak
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Joint laboratory of IPHYS and IOCHB
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Enzyme associated with the development of Alzheimer's disease controls neuronal growth during embryogenesis
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Bureš lectures in 2016
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Annual meeting IPHYS
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GABA-B - signalling cascades
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Poplatky zobrazovací techniky FGÚ Czech Bioimaging
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Schedule of lectures IPHYS - autumn - winter 2016
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Adaptation of the aural neuron code to statistics of stimulus
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Epi(c)run 2016
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Memorandum o vzájemné spolupráci mezi Nemocnicí Na Homolce a Akademií věd ČR
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Creation of new tissue replacements
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Image processing in microscopy (IEEE Trans. Med. Imaging 2013)
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Quantitative measurement of capillaries
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Isolation and culture of stem cells of the adipose tissue
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Improvement of existing tissue replacements
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Skin tissue engineering
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100 scientists in the secondary schools
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Lectures 2016
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Advancement Report - spring 2016
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The current knowledge about membrane transport in yeast is summarized in a new book.
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Book: Muscarinic Receptor: From Structure to Animal Models
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Towards predictive docking at aminergic G-protein coupled receptors.
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Lipid-based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice
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Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms
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Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors
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Molecular mechanisms of methoctramine binding and selectivity at muscarinic acetylcholine receptors
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New animal model of Alzheimer's disease may help to verify the effectiveness of a therapeutic approaches in the future
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Centre of Excellence BIOCEV was officially opened
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Lucie Kubínová was appointed a President of International Society for Stereology
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Library
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Two IPHYS scientists were gained Otto Wichterle Prize 2016
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Testing of new possibilities for the treatment of obesity
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Lucie Kubínová was awarded Prize of Czechoslovak Microscopy Society
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František Vyskočil was awarded Medal of The Learned Society of the Czech Republic
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A detailed explanation of insulin secretion stimulated by fatty acids help in diagnosing of type 2 diabetes
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Lectures 2015
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Aleš Stuchlík was appointed a Professor
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IPHYS stand at the Science Fair
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Three IPHYS employees were awarded "Letter of thanks of Czech Academy of Sciences"
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The results of the best IPHYS publication competition for year 2014
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The results of the best IPHYS publication competition for year 2013
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The results of the best IPHYS publication competition for year 2012
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The results of the best IPHYS publication competition for year 2011
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Qualitas logo
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Gender differences and atherosclerosis
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Academia Film Olomouc 2016
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Ing. Michaela Jirků
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Prof. RNDr. Tomáš Obšil, Ph.D.
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Dr. Jan Teisinger, CSc.
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Lecture invitation "Diet and blood vessels"
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Prof. Bohuslav Ošťádal was awarded G. J. Mendel Honorary Field Medal
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Electronic file room
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European Epileptology Award 2016 for prof. Pavel Mareš
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European Epileptology Award 2016 for prof. Pavel Mareš
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The excursion in Institute of Physiology
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Mutual interactions of various vasoactive systems, reactive oxygen species and G-proteins in experimental hypertension
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Hematology Analyzer scil Vet abc Plus+
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CentriVap Refrigerated Vacuum Concentrator
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Invitation - The 5th Czech Lipidomics Conference
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How do the Alzheimer disease patients orient in space?
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Imaging facility of IPHYS is part of the pilot phase of Euro-BioImaging
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The consequences of brain damage could worse increased body temperature
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OPPK Biomodels (2011-2013)
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OP VaVpl BIOCEV (2012-2015)
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Operational Programme Education for Competitiveness Popularization (2014-2015)
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Prof. Otakar Poupa and his work
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Epileptic seizure and what influences it?
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The aim of the research is a less invasive medical diagnostics
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Prof. Jiří Křeček a jeho působení v FGÚ
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ERC CZ (2012-2017)
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OPPK Microscope system (2012-2013)
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OPPK MitEnAl (2014)
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OPPK BrainView (2014-2015)
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Jan Jakubik is an editor of the prestigious publication
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Bureš lectures in 2015
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Institute of Physiology achieved above-average results in a tender for CSF grants
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A new role of cholesterol in the brain
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Laser microdissection
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Week of Science and Technology at Institute of Physiology
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Instruments
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The invitation to the lecture "Epilepsy - the storm in the brain"
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Tissue substitution
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Everyday Jet Lag
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Surface adjustment of hip arthroplasty
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Cognitive deficit - symptom of many of neuropsychiatric disorders
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Biomaterials and Tissue Engineering
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Differences in the sensitivity of the heart muscle to lack of oxygen between males and females
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Bowel functionality of the newborn is influenced also by the mother's timing system
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Bile acids prevents the development of obesity
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Chillies can reduce the pain
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The new findings make life with bipolar disorder easier
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Academy of Sciences awarded Helena Illnerová for long-term popularization of science
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The international conference of Organization for Computational Neurosciences CNS 2015
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Institute of Physiology has a new management
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Center for Development of Original Drugs (2012-2019)
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Preparation, modification and characterization of materials by radiation (2012-2018)
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Centre of mitochondrial biology and pathology - MITOCENTRE (2014-2018)
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Project of excellence in the field of neuroscience (2012-2018)
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Week of Science and Technology at Institute of Physiology
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QUALITAS - Wellbeing in health and disease
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Exhibition in the Academia bookstore
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Memory park
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Press conference "International day of epilepsy"
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Invitation for the lecture "Heart in the health and in the desease"
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Center of Biomedical Research (CBV) (2012-2015)
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BrainView and MitEnAl - two new EU projects at the Institute of Physiology
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Practical courses for future BIOCEV researchers are held at the Institute of physiology CAS
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Logo download
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internships offer for high school students
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Discover your limits in the Memory park
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Recent publication: Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver
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Recent publication: Human chronotype is determined in bodily cells under real-life conditions
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Recent publication: Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles.
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Recent publication: Alteration of the circadian clock in children with Smith-Magenis syndrome
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Three FGU employees were awarded Certificate of Recognition
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Our new publication: High resistance to mitochondrial mutations
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Michal Pravenec received Academic premium
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Institute of Physiology´s stand at the Science Exhibition
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Launch of the new confocal microscope
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Lecture "New Approaches to Drug Design: Multivalency in Drug Design for the Disease State"
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BRAINVIEW AND MITENAL – TWO NEW EU PROJECTS AT THE INSTITUTE OF PHYSIOLOGY
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The Promise of Circadian Biology
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Celebration of the 60th anniversary of the Institute of Physiology CAS
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Necrology of the eminent Czech physiologist prof. Jiří Křeček
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The heart stimulus changing the direction - the way of understanding of arrhythmias
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People with extreme chronotype are threatening getting up early
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Memory and Context: The Role of the Hippocampus
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Meeting of the International Symposium NEUROINFLAMMATION
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Institute of Physiology CAS opened the doors of laboratories for the visitors
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Jan Kopecký awarded for research on omega-3 fatty acids
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Practical courses for future BIOCEV researchers are held at the Institute of Physiology CAS
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From Genomes to Morphology – The Evolution of Developmental Diversity
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Brown adipose tissue: the mammalian prerogative
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Institute of Physiology CAS started operating of a new microscopy system
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How the brain is compensate for a lack of oxygen, damage, inflammation and infectiony by purinergic signaling
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Multiple Roles of Connexins in Biology and Medicine
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Scientists will help thanks to the animal models improve the life of the patients with schizophrenia
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Hippocampus and episodic memory
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Institute of Physiology is launching a new confocal microscope
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Marta Vandrovcová has been awarded Otto Wichterle prize
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The lecture "Heart in the health and in the desease
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Lecture "Insulin in Control of Energy Expenditure"
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Bureš lecture series invitation - Michael P. Czech
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Centre for cardiovascular research (2005-2011)
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Center of Neuropsychiatric Studies (2005-2009)
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Center for Applied Genomics (2005-2011)
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Flurescence microscopy in biological and medical research (2006-2011)
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Centre on molecular biology and physiology of yeast communities (2005-2011)
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Neuroscience Centre (2005-2011)
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Our New Paper in JBC: Structural Characterization of Phosducin and its Complex with the 14-3-3 Protein
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Tomáš Obšil was awarded the title of professor
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Josef Hlávka Award and Medal for 2014
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Quality Assurance System
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Mass spectrometer for metabolomics QTRAP 5500
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What depends on the internal clock of the human body?
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Our papers in 2014
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ROS modulation by membrane potential
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Functional characterization of ATP synthase deficiencies
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Bureš lectures in 2014
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Bureš lectures in 2013
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60th anniversary
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Chillies can reduce the pain
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9th February became The International day of epilepsy
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The unique challenges of a clinical trial focused on the impact of natural health products on cardiovascular disease
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Kalorimetrie malých hlodavců - INCA®
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Succes of Scientists at Conference of Czech Neuropsychopharmacological Society
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Prof. Bohuslav Ošťádal is the president of The International Academy of Cardiovascular Sciences
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Structural funds
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Effective method of transgenesis based on the transposon system Sleeping Beauty
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Fruitful Czech - Belgian collaboration with group of Dr. Pierra Morsomm from Université catholique de Louvain.
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Prof. František Vyskočil was awarded Silver medal of the Senate of PCR
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It starts entries for the winter semester courses
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Open day
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IMC 2014 - 18th World Congress of microscopy
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Lectures of the specialists from Institute of Physiology during Week of Science and technology 2014
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Studied Diseases
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Echokardiografický přístroj GE VIVID 7 DIMENSION
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Echokardiografický přístroj GE System Five
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60th anniversary of the Institute of Physiology
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Our new publication in Journal of Biological Chemistry: Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin.
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Bureš Lecture Series
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Physician of the Year 2013 is Přemysl Jiruška
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Labyrinth of microscopy
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Afternoon tea in the Committee of Good Will - The Olga Havel Foundation
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Effect of antiarrhythmic drugs in the chick embryo
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Obituary: Prof Jiří Křeček
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The role of oxidative stress in pathogenesis of epilepsy and seizures in immature brain
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The role of synaptic transmission modulation in pain
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The role of mitochondria in heart failure
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Získání grantu GA ČR
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Developmental aspects of cardiac ischemic tolerance
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Development of new diagnostic techniques of epilepsy
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Cardiac ischemic tolerance in systemic hypertension
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Public procurements
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Talented high school students were awarded
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Silver Medal of City of Prague for Professor Helena Illnerova
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Mitochondrial network and mtDNA organization, and genetic manipulations of mtDNA
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Specific mitochondrial metabolism in cancer cells
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Redox regulations in physiological and pathological processes of cell and organism
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Mechanisms responsible for seizure initiation and termination
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Study of cognitive functions in humans, spatial navigation and its impairment
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Cognitive and behavioural consequences of epilepsy
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Studentský Velemlok pro nejlepšího pedagoga
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Students tested their memory in Memory park
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Collaborators
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Organization of respirometric workshop
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Current grant support
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Single channel recording
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List of toxicology studies and tests
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60th anniversary of the Institute of Physiology.
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Research topics
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Recording and analysis of responses mediated by recombinant receptors
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Publications
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Brain damage and epilepsy development
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Public lecture of Prof. Helena Illnerova for Tomas Bata foundation "Our internal clock"
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60th anniversary - photogallery
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60th anniversary celebration
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The ontogenesis of the biological clock of laboratory rat
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Institutional award for the best paper
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Purkinje medal for prof. Mareš
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Neuropharmacological studies, animal models of brain disorders and new therapeutics
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Our new paper: Uncoupling of M1 muscarinic receptor/G protein interaction by amyloid β1-42
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Our new paper: On homology modeling of the M2 muscarinic acetylcholine receptor subtype
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Molecular regulation of axon growth and guidance
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Molecular and in vivo imaging, immediate-early genes, cognitive coordination and psychosis
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Two young Institute of Physiology´s scientists were awarded Otto Wichterle prize
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Methodical approaches
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Our new paper: Mitochondrial glycerol-3-phosphate dehydrogenase and oxygen radicals
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Conformational stress in Alzheimer’s disease
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Cardioprotective mechanism of chronic hypoxia
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Přemysl Jiruška, M.D., Ph.D. was awarded Jessenius prize
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We look for antifungal drugs as a part of a European consortium
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HEK293 transfection – MATra
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Glutamate receptors
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Excursion at the Institute of Physiology
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Prize for the best lecture and poster
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Helena Janíčková was awarded
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Cellular mechanisms of nociception
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The biological timing system in healthy volunteers and patients with neuropsychiatric disorders
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Bioenergetics of rare diseases
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Successful animated character from the Academy of Sciences of the CR
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Prof. Helena Illnerová was a Science Café guest in New PORG high school
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Patch clamp recording
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Student Progress Report Meeting 2024
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Studying bone marrow adiposity in mouse models of obesity: impact of sex dimorphism
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Biogenesis and regulation of mitochondrial oxidative phosphorylation apparatus
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Crosstalk of glucose-induced lipid metabolism and redox homeostasis in beta-cell physiology and pathology
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Fluorescence probes for the study of cell membranes
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Mechanisms of gliflozins action in the treatment of non-diabetic experimental models of cardiovascular diseases
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Mechanisms of selective modulation of individual subtypes of muscarinic receptors
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Nicotinic acetylcholine receptors expressed by specific neuronal populations
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Mechanisms and treatment of pain
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Structural Biology of Signalling Proteins - annotation
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Metabolism of Bioactive Lipids - annotation
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Bioenergetics - annotation
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Adipose Tissue Biology - annotation
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Molecular Physiology of Bone - annotation
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Experimental Hypertension - annotation
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Biological Rhythms - annotation
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Molecular Neurobiology - annotation
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Neurochemistry - annotation
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Cellular Neurophysiology - annotation
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CALL FOR APPLICATIONS
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Jak funguje vaše paměť?
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Logo for download
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Press releases
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Karel Čapek, M.D., Ph.D. (1925-2002)
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Prof. RNDr. František Kolář, CSc.
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MUDr. Pavel Flachs, Ph.D.
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Vliv perinatální hypoxie na odolnost srdečního svalu k nedostatku kyslíku v dospělosti závisí na pohlaví
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Advancement Report - 2021 (on-line)
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The results of the best IPHYS publication competition for year 2019
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Rozvoj HR kapacit, internacionalizace, popularizace a využití IP II. (2020 - 2022)
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Optogenetické manipulace interneuronů v animálním modelu schizofrenie (2020 - 2022)
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FGU Mobilita II. (2020 - 2022)
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The Best Poster Award
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Advancement Report - 2020
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Molecular mechanisms of TRPV1, TRPV2 and TRPA1 activation
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Development of nanodiamond-covered recording chambers for cultivation of neurons
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Role of linker regions in the signal transduction between the ligand-binding domain and the ion channel of the NMDA receptor
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Functional Effects of Glutamate Receptor Mutations in Human Diseases
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Applications
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Prekliniky logo
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Aleš Stuchlík obdržel titul DSc.
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Oddělení neurofyziologie paměti získalo grant v programu HORIZONT 2020
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Přednáška "Paměť, stárnutí a Alzheimerova choroba"
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Ústav organické chemie a biochemie a Fyziologický ústav podepsaly licenční smlouvu s Novo Nordisk
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LECTURES SCHEDULE
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LipDiDiet (2008-2013)
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EURATRANS (2010-2014)
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Cornucopia (2011-2015)
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BIOCLAMS (2010–2015)
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DIABAT (2011–2015)
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Fotogalerie
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Advancement Report 2014
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2012