In recent years, changes in GRIN genes encoding NMDAR subunits have been identified in a number of human patients with neurodevelopmental disorders, including schizophrenia, intellectual disability, epilepsy, and autism.  Our team uses genetics, molecular biology, biochemistry, patch-clamp electrophysiology, live-cell Ca2+ imaging, and behavioral analyses to study how pathogenic GRIN mutations affect NMDAR function, synaptic transmission, neuronal network activity, and animal behavior.