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Our new paper: Ivermectin action on ligand-gated ion channels


Ivermectin is a large lipophilic molecule that acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel, gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. This review summarizes what is currently known about ivermectin binding and modulation of Cys-loop receptor family of ligand-gated ion channels and what are the critical structural determinants underlying potentiation of the P2X4 receptor channel.

Zemkova H, Tvrdonova V, Bhattacharya A, Jindrichova M: Allosteric modulation of ligand gated ion channels by ivermectin.

http://www.ncbi.nlm.nih.gov/pubmed/24564661