TRPV1 and TRPA1 are intrinsically voltage sensitive and thermal and chemical stimuli act to increase their voltage sensitivities. We explore the molecular basis for the voltage-dependent gating in these channels and to understand the physiological significance of this property for nociception.
An intracellular cavity in the sensor domain of the ion channel TRPA1 coordinates electrophilic, voltage and calcium sensitivity. FIgure illustrates electrostatic potential surrounding TRPA1. Red mesh indicates negative electrostatic potential in the selectivity filter and inside the pore. Positive electrostatic potential (blue mesh) permeates into the intracellular part of the sensor domain (Zimova et al., Science Signaling, 11, 514, 2018).