Polidarová, L., Sládek, M., Nováková, M., Parkanová, D. & Sumová, A. Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver. PLoS One 8, e75690 (2013).
The spontaneously hypertensive rat (SHR) is an inbred laboratory model with a number of metabolic disorders. In the previous work, we showed that SHR circadian system is disrupted, resulting in phase advancing clock and desynchrony of peripheral organs. In the current paper, we describe the increased sensitivity of the circadian system of the SHR to the time-restricted feeding regime and its association with Bmal2 gene activity in the liver.
Daily rhythm of BMAL2 protein in the liver is phase advanced in SHR compared to Wistar (A, B). Locomotor activity, just before the food is accessible (C), is significantly higher in SHR.