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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Biochemistry of Membrane Receptors

Biochemistry of Membrane Receptors

Our research focuses on the cellular and molecular mechanisms of desensitization of hormone response mediated by the activation of G protein coupled receptors (GPCR). G protein coupled receptors are plasma membrane integral proteins which serve as transducers of extracellular signals across the plasma membrane bilayer to the cell interior. GPCR play a key role in the regulation of many physiological processes and functions. Moreover, GPCRs represent one of the most important groups of targets for therapeutics.

 

The main areas of the research are:

 

  • The role of cell membrane and membrane domains
  • Opioid receptors and drug addiction
  • The effect of monovalent ions on δ-opioid receptors – analysis of lithium effect in living cells and isolated cell membranes

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The role of cell membrane and membrane domains

Cell (plasma) membrane (PM) serves as a protective barrier, but also plays a role in the cellular communication. The integrity of hydrophobic lipid environment of PM is an important factor affecting… More

Opioid receptors and drug addiction

Addiction to opioid drugs (opioids) represents one of the most severe forms of drug abuse. Opium is one of the oldest known drugs and is used for its medicinal and euphoric effects for thousands of… More

Publications 2015 - 2019

2019 Melcrová; Adéla - Pokorná; Šárka - Vošahlíková; Miroslava - Sýkora; Jan - Svoboda; Petr - Hof; Martin - Cwiklik; Lukasz - Jurkiewicz; Piotr . Concurrent Compression of Phospholipid… More