Interactions of renin-angiotensin system, endothelin and CYP-450 in chronic kidney disease
Chronic kidney disease (CKD) is a life-threatening disease arising as a frequent consequence of diabetes and hypertension. Substantial role of endothelin-1 (ET-1), and renin-angiotensin system (RAS) in the pathogenesis of both human and experimental CKD has been demonstrated. Recently, attention is being paid to the role of metabolites of cytochrome P-450 [hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs)] in CKD. We plan to evaluate the impact of various combined interventions into the above mentioned humoral systems on CKD development and related alterations in blood pressure and progression of end-organ damage.