Intranet

INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

New publication: Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment

New publication: Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment Saliva melatonin (left) and buccal Bmal1 mRNA (right) levels of patients with AD (red) and healthy controls (black) in their home environment.

Weissová, Kamila - Bartoš, A. - Sládek, Martin - Nováková, Marta - Sumová, Alena . Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment. PLoS ONE 11 (2016) e0146200

Alzheimer's disease (AD) is a neurodegenerative disease, often accompanied by impaired rhythms of sleep and wakefulness. In our pilot study, we examined the sleep parameters (diaries and actigraphy), circadian melatonin levels and the expression of clock genes Per1 and Bmal1 in 13 patients with mild AD in their home environment; 13 healthy patient's spouses served as controls. Our results suggest only moderate differences in functional state of the circadian system of AD patients, mainly in the form of a greater number of naps and abnormal melatonin profiles.