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Cutting-edge science for health

Consequences of early brain-damage and prevention of development of epilepsy and functional damage

Consequences of early brain-damage  and prevention of development of  epilepsy and functional damage

Kubová et al, J. Neurosci, 2001

Kubová et al, Eur. J. Neurosci, 2004

Tsenov et al, Epilepsia, 2007

Máteffyová et al, Eur. J. Neurosci., 2006

Nairismägi et al, Epilepsia, 2006

Kubová et Mareš, Neuroscience, 2013

Tsenov et al, Exp. Neurol., 2015

Suchomelova et al, Neuroscience, 2015

Szczurowska et al, Exp. Neurol. 2016

Brain-damaging insult triggers a cascade of molecular, cellular and structural changes that eventually lead to behavioral alterations and development of epilepsy. The response to the particular brain insult is highly age-dependent. Our aim is to study effects of early insults on the brain development at the molecular, cellular, and circuitry levels (maturation of receptors or ionic channel structures, vascularisation, myelination, circuitry maturation, etc.) and consequently on maturation of more complex brain functions (cognitive functions, sensorimotor skills, social and emotional behavior, brain excitability, etc.). Results of our research can be used to develop age specific pharmacological strategies for prevention of epilepsy development and disturbances of brain function.