Our genes determine whether we are rather an early bird or an owl. If we do not live in accordance with our inner rhythm, our health can be in danger.
Therefore, we study molecular adjustment of our inner biological clock under the influence of external time and also health problems resulting from a defect of this process. We also investigate disorders of time regulation at various psychiatric and neurological diseases that are accompanied by sleep disorders (e.g. bipolar disorder, Alzheimer’s disease, hypersomnia).
Daily rhythmical expression of clock gene Bmal1 measured in fibroblast cultures from skin biopsies of two healthy volunteers. The rhythm runs faster, i.e. with a shorter period, in the volunteer depicted in blue compared to the volunteer depicted in red. Details at the website of Department of Neurohumoral Regulations.