From the left: Central clock in the brain - the suprachiasmatic nucleus (SCN); glial cells in the SCN; lcocomotor activity records of rats; neurons in hippocampus; clock gene expression in the SCN with a phase plot.
Please, consider filing out anonymous questionnaire regarding your chronotype and social jet lag.
In the center of our interest is the endogenous time-keeping system, circadian clock of mammals, including humans. The system temporally regulates rhythmic processes in our body so that they take place at the proper time of day and are optimally synchronized relative to each other.
A failure of the temporal regulation has a negative impact on human health. Using in vivo and in vitro models, we study the molecular mechanisms underlying the circadian clock as well as the resulting physiological and behavioral rhythms.
We focus on the following questions:
- What are the mechanisms for entraining (synchronizing) the circadian system and what are the consequences of its failure?
- How does the circadian system develop and how is it being entrained during ontogeny?
- How is the circadian system of humans entrained in real life conditions, both in health and in disease?
Fig. PER2 protein in the SCN, 7 days ex vivo recording.
Projects
We explore the entrainment of the circadian clock and its disorders on various experimental models in vivo and in vitro.
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The mammalian biological clock initiates its ontogenesis already during embryonic development in the maternal uterus. Newborn mammals are equipped with clock running in accordance with the maternal clock. We focus on investigating when and how do the newborn clock develop and entrain.
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Research in our laboratory focuses on the timing system not only in healthy volunteers but also in patients suffering from disorders associated with disrupted sleep pattern. The aim of our projects is to find connections between the functional state of the timing system and those disorders.
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Achievements
Milica Drapšin, Tereza Dočkal, Pavel Houdek, Martin Sládek, Kateryna Semenovykh, Alena Sumová. Brain Behav Immun. 2024 Jan 25:S0889-1591(24)00229-0. doi: 10.1016/j.bbi.2024.01.217.
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Martin Sládek, Jan Klusáček, Dana Hamplová and Alena Sumová. Sleep 2023 Feb 24, 10.1093/sleep/zsad037. Social jetlag, or chronic misalignment between biological and social time, is the most common disturbance of circadian rhythms in modern society.
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Karolína Liška, Tereza Dočkal, Pavel Houdek, Martin Sládek, Vendula Lužná, Kateryna Semenovykh, Milica Drapšin and Alena Sumová.
Lithium affects the circadian clock in the choroid plexus – A new role for an old mechanism. Biomedicine & Pharmacotherapy 159 (2023), 114292
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doi:10.1371/journal.pbio.3001637.g005. Our results indicate the importance of a well-functioning maternal biological clock in providing rhythmic environment during the fetal brain development.
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doi:10.1007/s00018-022-04354-7. Misaligned meals become a frequent lifestyle transgression related to current societal pressure imposed on behavior.
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Publications
Drapšin; Milica - Dočkal; Tereza - Houdek; Pavel - Sládek; Martin - Semenovykh; Kateryna - Sumová; Alena
.
Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption
.
Brain Behavior and Immunity. 2024; 117(March); 255-269
.
IF = 15.1
[ASEP]
[
doi
]
Sládek; Martin - Klusáček; Jan - Hamplová; Dana - Sumová; Alena
.
Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules
.
Sleep. 2023; 46(6)); zsad037
.
IF = 5.6
[ASEP]
[
doi
]
Liška; Karolína - Dočkal; Tereza - Houdek; Pavel - Sládek; Martin - Lužná; Vendula - Semenovykh; Kateryna - Drapšin; Milica - Sumová; Alena
.
Lithium affects the circadian clock in the choroid plexus – A new role for an old mechanism
.
Biomedicine & Pharmacotherapy. 2023; 159(March)); 114292
.
IF = 7.5
[ASEP]
[
doi
]
Honzlová; Petra - Sumová; Alena
.
Metabolic regulation of the circadian clock in classically and alternatively activated macrophages
.
Immunology and Cell Biology. 2023; 101(5); 428-443
.
IF = 4.0
[ASEP]
[
doi
]
Honzlová; Petra - Semenovykh; Kateryna - Sumová; Alena
.
The Circadian Clock of Polarized Microglia and Its Interaction with Mouse Brain Oscillators
.
Cellular and Molecular Neurobiology. 2023; 43(3); 1319-1333
.
IF = 4.0
[ASEP]
[
doi
]
Vejražková; D. - Vaňková; M. - Včelák; J. - Krejčí; H. - Anderlová; K. - Tura; A. - Pacini; G. - Sumová; Alena - Sládek; Martin - Bendlová; B.
The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose; Insulin and C-peptide Kinetics
.
Frontiers in Endocrinology. 2022; 13); 868364
.
IF = 5.2
[ASEP]
[
doi
]
Shi; S.-Q. - Mahoney; C. E. - Houdek; Pavel - Zhao; W. - Anderson; M. P. - Zhuo; X. - Beaudet; A. - Sumová; Alena - Scammell; T. E. - Johnson; C. H.
Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a
.
Frontiers in Behavioral Neuroscience. 2022; 16(Mar 23)); 837523
.
IF = 3.0
[ASEP]
[
doi
]
Liška; Karolína - Sládek; Martin - Houdek; Pavel - Shrestha; N. - Lužná; Vendula - Ralph; M. R. - Sumová; Alena
.
High Sensitivity of the Circadian Clock in the Hippocampal Dentate Gyrus to Glucocorticoid- and GSK3-Beta-Dependent Signals
.
Neuroendocrinology. 2022; 112(4); 384-398
.
IF = 4.1
[ASEP]
[
doi
]
Honzlová; Petra - Novosadová; Zuzana - Houdek; Pavel - Sládek; Martin - Sumová; Alena
.
Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks
.
Cellular and Molecular Life Sciences. 2022; 79(6)); 318
.
IF = 8.0
[ASEP]
[
doi
]
Greiner; Philipp - Houdek; Pavel - Sládek; Martin - Sumová; Alena
.
Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach
.
PLOS Biology. 2022; 20(5)); e3001637
.
IF = 9.8
[ASEP]
[
doi
]
Abbondanza; Alice - Bas; Irina Ribeiro - Modrák; Martin - Čapek; Martin - Minich; Jessica - Tyshkevich; Alexandra - Naser; Shahed - Rangotis; Revan - Houdek; Pavel - Sumová; Alena - Dumas; S. - Bernard; V. - Janíčková; Helena
.
Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors
.
Journal of Neuroscience. 2022; 42(13); 2786-2803
.
IF = 5.3
[ASEP]
[
doi
]
Sládek; Martin - Liška; Karolína - Houdek; Pavel - Sumová; Alena
.
Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus
.
Neuropharmacology. 2021; 185(Mar 1)); 108455
.
IF = 5.273
[ASEP]
[
doi
]
Ralph; M. R. - Shi; S.-Q. - Johnson; C. H. - Houdek; Pavel - Shrestha; T. C. - Crosby; P. - O´Neill; J. S. - Sládek; Martin - Stinchcombe; A. R. - Sumová; Alena
.
Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice
.
PLoS Computational Biology. 2021; 17(5)); e1008987
.
IF = 4.779
[ASEP]
[
doi
]
Lužná; Vendula - Liška; Karolína - Sládek; Martin - Sumová; Alena
.
Hormonal fine-tuning of clock in decidual region of mouse placenta by dopamine; melatonin; insulin; leptin and ghrelin
.
Placenta. 2021; 108(May); 55-63
.
IF = 3.287
[ASEP]
[
doi
]
Lužná; Vendula - Houdek; Pavel - Liška; Karolína - Sumová; Alena
.
Challenging the Integrity of Rhythmic Maternal Signals Revealed Gene-Specific Responses in the Fetal Suprachiasmatic Nuclei
.
Frontiers in Neuroscience. 2021; 14(Jan 7)); 613531
.
IF = 5.152
[ASEP]
[
doi
]
Liška; Karolína - Sládek; Martin - Čečmanová; Vendula - Sumová; Alena
.
Glucocorticoids reset circadian clock in choroid plexus via period genes
.
Journal of Endocrinology. 2021; 248(2); 155-166
.
IF = 4.669
[ASEP]
[
doi
]
Sumová; Alena - Čečmanová; Vendula
.
Mystery of rhythmic signal emergence within the suprachiasmatic nuclei
.
European Journal of Neuroscience. 2020; 51(1); 300-309
.
IF = 3.386
[ASEP]
[
doi
]
Sládek; Martin - Röschová; Michaela - Adámková; V. - Hamplová; Dana - Sumová; Alena
.
Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe
.
Scientific Reports. 2020; 10(1)); 1419
.
IF = 4.379
[ASEP]
[
doi
]
Dodge; A. - Peters; M. M. - Greene; H. E. - Dietrick; C. - Botelho; R. - Chung; D. - Willman; J. - Nenninger; A. W. - Ciarlone; S. - Kamath; S. G. - Houdek; Pavel - Sumová; Alena - Anderson; A. E. - Dindot; S. V. - Berg; E. L. - O´Geeen; H. - Segal; D. J. - Silverman; J. L. - Weeber; E. J. - Nash; K. R.
Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion
.
Autism Research. 2020; 13(3); 397-409
.
IF = 5.216
[ASEP]
[
doi
]
Sládek; Martin - Houdek; Pavel - Sumová; Alena
.
Circadian profiling reveals distinct regulation of endocannabinoid system in the rat plasma; liver and adrenal glands by light-dark and feeding cycles
.
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2019; 1864(12)); 158533
.
IF = 3.367
[ASEP]
[
doi
]
Sládek, Martin - Sumová, Alena
.
Modulation of NMDA-Mediated Clock Resetting in the Suprachiasmatic Nuclei of mPer2(Luc) Mouse by Endocannabinoids
.
Frontiers in physiology 2019, 10(Mar 29)), 361
.
IF = 4.519
[ASEP]
[
doi
]
Čečmanová; Vendula - Houdek; Pavel - Šuchmanová; Karolína - Sládek; Martin - Sumová; Alena
.
Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids
.
Journal of Biological Rhythms. 2019; 34(3); 307-322
.
IF = 3.122
[ASEP]
[
doi
]
Shrestha, T. C. - Šuchmanová, Karolína - Houdek, Pavel - Sumová, Alena - Ralph, M. R.
Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks
.
Scientific Reports 2018, 8(Oct 19)), 15547
.
IF = 4.011
[ASEP]
[
doi
]
Petrásek, Tomáš - Vojtěchová, Iveta - Lobellová, Veronika - Popelíková, Anna - Janíková, Martina - Brožka, Hana - Houdek, Pavel - Sládek, Martin - Sumová, Alena - Krištofíková, Z. - Valeš, Karel - Stuchlík, Aleš
.
The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity
.
Frontiers in Aging Neuroscience 2018, roč. 10, Aug 28, článku 250
.
IF = 3.633
[ASEP]
[
doi
]
Olejníková, Lucie - Polidarová, Lenka - Sumová, Alena
.
Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid‐dependent mechanism
.
Acta Physiologica 2018, roč. 223, 1, článku e13020
.
IF = 5.868
[ASEP]
[
doi
]
Olejníková, Lucie - Polidarová, Lenka - Behuliak, Michal - Sládek, Martin - Sumová, Alena
.
Circadian alignment in a foster mother improves the offspring's pathological phenotype
.
Journal of Physiology 2018, 596(23), 5757-5775
.
IF = 4.950
[ASEP]
[
doi
]
Novosadová, Zuzana - Polidarová, Lenka - Sládek, Martin - Sumová, Alena
.
Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2(Luc) mice
.
Scientific Reports 2018, roč. 8, Aug 3, článku 11668
.
IF = 4.011
[ASEP]
[
doi
]
Polidarová, Lenka - Sládek, Martin - Novosadová, Zuzana - Sumová, Alena
.
Aging does not compromise in vitro oscillation of the suprachiasmatic nuclei but makes it more vulnerable to constant light
.
Chronobiology International. 2017, roč. 34, 1, p. 105-117
.
IF = 2.643
[ASEP]
[
doi
]
Polidarová, Lenka - Houdek, Pavel - Sumová, Alena
.
Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon
.
Chronobiology International. 2017, roč. 34, 9, p. 1273-1287
.
IF = 2.643
[ASEP]
[
doi
]
Polidarová, Lenka - Houdek, Pavel - Sládek, Martin - Novosadová, Zuzana - Pácha, Jiří - Sumová, Alena
.
Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
.
Chronobiology International. 2017, roč. 34, 1, p. 1-16
.
IF = 2.643
[ASEP]
[
doi
]
Májovský, M. - Řezáčová, Lenka - Sumová, Alena - Pospíšilová, L. - Netuka, D. - Bradáč, O. - Beneš, V.
Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection
.
Journal of Clinical Neuroscience. 2017, roč. 39, May 2017, p. 155-163
.
IF = 1.640
[ASEP]
[
doi
]
Weissová, Kamila - Bartoš, A. - Sládek, Martin - Nováková, Marta - Sumová, Alena
.
Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment
.
PLoS ONE. 2016, roč. 11, 1, e0146200
.
IF = 2.806
[ASEP]
[
doi
]
Soták, Matúš - Bryndová, Jana - Ergang, Peter - Vagnerová, Karla - Kvapilová, Pavlína - Vodička, Martin - Pácha, Jiří - Sumová, Alena
.
Peripheral circadian clocks are diversely affected by adrenalectomy
.
Chronobiology International. 2016, roč. 33, 5, p. 520-529
.
IF = 2.562
[ASEP]
[
doi
]
Houdek, Pavel - Nováková, Marta - Polidarová, Lenka - Sládek, Martin - Sumová, Alena
.
Melatonin is a redundant entraining signal in the rat circadian system
.
Hormones and Behavior. 2016, roč. 83, Jul, p. 1-5
.
IF = 3.378
[ASEP]
[
doi
]
Olejníková, Lucie - Polidarová, Lenka - Paušlyová, Lucia - Sládek, Martin - Sumová, Alena
.
Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease
.
Chronobiology International. 2015, Vol. 32, 4, p. 531-547
.
IF = 3.54
[ASEP]
[
doi
]
Houdek, Pavel - Polidarová, Lenka - Nováková, Marta - Matějů, Kristýna - Kubík, Štěpán - Sumová, Alena
.
Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver
.
Developmental Neurobiology. 2015, Vol. 75, 2, p. 131-144
.
IF = 2.529
[ASEP]
[
doi
]
Nováková, Marta - Praško, J. - Látalová, K. - Sládek, Martin - Sumová, Alena
.
The circadian system of patients with bipolar disorder differs in episodes of mania and depression
.
Bipolar Disorders. 2015, Vol. 17, 3, p. 303-314
.
IF = 4.882
[ASEP]
[
doi
]
Soták, Matúš - Sumová, Alena - Pácha, Jiří
.
Cross-talk between the circadian clock and the cell cycle in cancer
.
Annals of Medicine 2014, roč. 46, 4, p. 221-232. ISSN 0785-3890.
IF = 3.886
[ASEP]
[
doi
]
Polidarová, Lenka - Olejníková, Lucie - Paušlyová, Lucia - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena
.
Development and entrainment of the colonic circadian clock during ontogenesis
.
American Journal of Physiology-Gastrointestinal and Liver Physiology 2014, roč. 306, 4, g346-g356. ISSN 0193-1857.
IF = 3.798
[ASEP]
[
doi
]
Petrásek, Tomáš - Prokopová, Iva - Sládek, Martin - Weissová, Kamila - Vojtěchová, Iveta - Bahník, Štěpán - Zemanová, Anna - Schönig, K. - Berger, S. - Tews, B. - Bartsch, D. - Schwab, M. E. - Sumová, Alena - Stuchlík, Aleš
.
Human osteoblast-like MG 63 cells on polysulfone modified with carbon nanotubes or carbon nanohorns
.
Frontiers in Behavioral Neuroscience 2014, roč. 8, mar 18, p. 90. ISSN 1662-5153.
IF = 3.27
[ASEP]
[
doi
]
Nováková, Marta - Sumová, Alena
.
New methods to assess circadian clocks in humans
.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 2014, roč. 52, 5, p. 404-412. ISSN 0019-5189.
IF = 0.835
[ASEP]
Houdek, Pavel - Sumová, Alena
.
In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei
.
PLoS ONE 2014, roč. 9, 9, e107360. ISSN 1932-6203.
IF = 3.234
[ASEP]
[
doi
]
Bendová, Zdeňka - Janoušková, Hana - Svobodová, Irena
.
Circadian rhythm and photic induction of the C-terminal splice variant of NMDAR1 subunit in the rat suprachiasmatic nucleus
.
Synapse 2014, roč. 68, 2, p. 85-88. ISSN 0887-4476.
IF = 2.127
[ASEP]
[
doi
]
Zhang, L. - Hastings, M. H. - Green, E. W. - Tauber, E. - Sládek, Martin - Webster, S. G. - Kyriacou, C. P. - Wilcockson, D. C.
Dissociation of Circadian and Circatidal Timekeeping in the Marine Crustacean Eurydice pulchra
.
Current Biology, 2013, Vol. 23, 19, p. 1863-1873
.
IF = 9.494
[ASEP]
[
doi
]
Soták, Matúš - Polidarová, Lenka - Ergang, Peter - Sumová, Alena - Pácha, Jiří
.
An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors
.
International Journal of Cancer, 2013, Vol. 132, 5, p. 1032-1041
.
IF = 6.198
[ASEP]
[
doi
]
Sládek, Martin - Sumová, Alena
.
Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles
.
PLoS ONE, 2013, Vol. 8, 10, e77010
.
IF = 3.730
[ASEP]
[
doi
]
Pácha, Jiří - Sumová, Alena
.
Circadian regulation of epithelial functions in the intestine
.
Acta Physiologica, 2013, Vol. 208, 1, p. 11-24
.
IF = 4.382
[ASEP]
[
doi
]
Polidarová, Lenka - Sládek, Martin - Nováková, Marta - Parkanová, Daniela - Sumová, Alena
.
Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver
.
PLoS ONE, 2013, Vol. 8, 9, e75690
.
IF = 3.730
[ASEP]
[
doi
]
Nováková, Marta - Sládek, Martin - Sumová, Alena
.
Human Chronotype Is Determined in Bodily Cells Under Real-Life Conditions
.
Chronobiology International, 2013, Vol. 30, 4, p. 607-617
.
IF = 4.350
[ASEP]
[
doi
]
Šanda, Pavel - Maršálek, P.
Stochastic interpolation model of the medial superior olive neural circuit
.
Brain Research, 2012, Vol. 1434, JAN 24, p. 257-265
.
IF = 2.879
[ASEP]
[
doi
]
Sumová, Alena - Sládek, Martin - Polidarová, Lenka - Nováková, Marta - Houdek, Pavel
.
Circadian system from conception till adulthood
.
Progress in Brain Research, 2012, Vol. 199, 2012, p. 83-103
.
IF = 4.191
[ASEP]
[
doi
]
Sládek, Martin - Polidarová, Lenka - Nováková, Marta - Parkanová, Daniela - Sumová, Alena
.
Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats
.
PLoS ONE, 2012, Vol. 7, 10, e46951
.
IF = 3.730
[ASEP]
[
doi
]
Parkanová, Daniela - Nováková, Marta - Sosniyenko, Serhiy - Sumová, Alena
.
Photoperiodic modulation of the hepatic clock by the suprachiasmatic nucleus and feeding regime in mice
.
European Journal of Neuroscience, 2012, Vol. 35, 9, p. 1446-1457
.
IF = 3.753
[ASEP]
[
doi
]
Nováková, Marta - Nevšímalová, S. - Příhodová, I. - Sládek, Martin - Sumová, Alena
.
Alteration of the Circadian Clock in Children with Smith-Magenis Syndrome
.
Journal of Clinical Endocrinology and Metabolism, 2012, Vol. 97, 2, E312-E318
.
IF = 6.430
[ASEP]
[
doi
]
Bendová, Zdeňka - Sládek, Martin - Svobodová, Irena
.
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation
.
Neurochemistry International, 2012, Vol. 61, 1, p. 43-47
.
IF = 2.659
[ASEP]
[
doi
]
Soták, Matúš - Polidarová, Lenka - Musílková, Jana - Hock, Miroslav - Sumová, Alena - Pácha, Jiří
.
Circadian regulation of electrolyte absorption in the rat colon
.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011, Vol. 301, 6, G1066-G1074
.
IF = 3.431
[ASEP]
[
doi
]
Polidarová, Lenka - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena
.
Hepatic, Duodenal, and Colonic Circadian Clocks Differ in their Persistence under Conditions of Constant Light and in their Entrainment by Restricted Feeding
.
Chronobiology International, 2011, Vol. 28, 3, p. 204-215
.
IF = 4.028
[ASEP]
[
doi
]
Nováková, Marta - Paclt, I. - Ptáček, R. - Kuželová, H. - Hájek, Ivan - Sumová, Alena
.
Salivary Melatonin Rhythm as a Marker of the Circadian System in Healthy Children and Those With Attention-Deficit/Hyperactivity Disorder
.
Chronobiology International, 2011, Vol. 28, 7, p. 630-637
.
IF = 4.028
[ASEP]
[
doi
]
Nováková, Marta - Polidarová, Lenka - Sládek, Martin - Sumová, Alena
.
Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light
.
Neuroscience, 2011, Vol. 197, -, p. 65-71
.
IF = 3.380
[ASEP]
[
doi
]
Sosniyenko, Serhiy - Parkanová, Daniela - Illnerová, Helena - Sládek, Martin - Sumová, Alena
.
Different mechanisms of adjustment to a change of the photoperiod in the suprachiasmatic and liver circadian clocks
.
American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2010, Vol. 298, 4, R959-R971
.
IF = 3.284
[ASEP]
[
doi
]
Nováková, Marta - Sládek, Martin - Sumová, Alena
.
Exposure of Pregnant Rats to Restricted Feeding Schedule Synchronizes the SCN Clocks of Their Fetuses under Constant Light but Not under a Light-Dark Regime
.
Journal of Biological Rhythms, 2010, Vol. 25, 5, p. 350-360
.
IF = 3.309
[ASEP]
[
doi
]
Matějů, Kristýna - Sumová, Alena - Bendová, Zdeňka
.
Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats
.
Journal of Comparative Neurology, 2010, Vol. 518, 17, p. 3630-3644
.
IF = 3.774
[ASEP]
[
doi
]
Zíková, Martina - Corlett, Alicia - Bendová, Zdeňka - Pajer, Petr - Bartůněk, Petr
.
DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism
.
Molecular Endocrinology, 2009, Vol. 23, 4, p. 520-528
.
IF = 5.257
[ASEP]
[
doi
]
Walton, K. M. - Fisher, K. - Rubitski, D. - Marconi, M. - Meng, Q.-J. - Sládek, Martin - Adams, J. - Bass, M. - Chandrasekaran, R. - Butler, T. - Griffor, M. - Rajamohan, F. - Serpa, M. - Chen, Y. - Claffey, M. - Hastings, M. - Loudon, A. - Maywood, E. -
.
Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period
.
Journal of Pharmacology and Experimental Therapeutics, 2009, Vol. 330, 2, p. 430-439
.
IF = 4.093
[ASEP]
[
doi
]
Sosniyenko, Serhiy - Hut, R.A. - Daan, S. - Sumová, Alena
.
Influence of photoperiod duration and light–dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus
.
European Journal of Neuroscience, 2009, Vol. 30, 9, p. 1802-1814
.
IF = 3.418
[ASEP]
[
doi
]
Polidarová, Lenka - Soták, Matúš - Sládek, Martin - Pácha, Jiří - Sumová, Alena
.
Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint Kinase Wee1 Expression along the Gut
.
Chronobiology International, 2009, Vol. 26, 4, p. 607-620
.
IF = 3.987
[ASEP]
[
doi
]
Matějů, Kristýna - Bendová, Zdena - El-Hennamy, Rehab - Sládek, Martin - Sosniyenko, Serhiy - Sumová, Alena
.
Development of the light sensitivity of the clock genes Period1 and Period2, and immediate-early gene c-fos within the rat suprachiasmatic nucleus
.
European Journal of Neuroscience, 2009, Vol. 29, 3, p. 490-501
.
IF = 3.418
[ASEP]
[
doi
]
Bendová, Zdeňka - Sumová, Alena - Mikkelsen, J. D.
Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus
.
Neuroscience, 2009, Vol. 159, 2, p. 599-609
.
IF = 3.292
[ASEP]
[
doi
]
Sumová, Alena - Bendová, Zdeňka - Sládek, Martin - El-Hennamy, Rehab - Matějů, Kristýna - Polidarová, Lenka - Sosniyenko, Serhiy - Illnerová, Helena
.
Circadian molecular clocks tick along ontogenesis
.
Physiological Research, 2008, Vol. 57, Suppl.3, S139-S148
.
IF = 1.653
[ASEP]
El-Hennamy, Rehab - Matějů, Kristýna - Bendová, Zdena - Sosniyenko, Serhiy - Sumová, Alena
.
Maternal Control of the Fetal and Neonatal Rat Suprachiasmatic Nucleus
.
Journal of Biological Rhythms, 2008, Vol. 23, 5, p. 435-444
.
IF = 4.211
[ASEP]
[
doi
]
Blažejová, K. - Illnerová, Helena - Hájek, Ivan - Nevšímalová, S.
Circadian rhythm in salivary melatonin in narcoleptic patiens
.
Neuroscience Letters, 2008, Vol. 437, 2, p. 162-164
.
IF = 2.200
[ASEP]
[
doi
]
Sumová, Alena - Kováčiková, Zuzana - Illnerová, Helena
.
Dynamics of the Adjustment of Clock Gene Expression in the Rat Suprachiasmatic Nucleus to an Asymmetrical Change from a Long to a Short Photoperiod
.
Journal of Biological Rhythms, 2007, Vol. 22, 3, p. 259-267
.
IF = 3.868
[ASEP]
Sládek, Martin - Jindráková, Zuzana - Bendová, Zdeňka - Sumová, Alena
.
Postnatal ontogenesis of the circadian clock within the rat liver
.
American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2007, Vol. 292, 3, R1224-R1229
.
IF = 3.661
[ASEP]
Sládek, Martin - Rybová, Markéta - Jindráková, Zuzana - Zemanová, Zdeňka - Polidarová, Lenka - Mrnka, Libor - O´Neill, J. - Pácha, Jiří - Sumová, Alena
.
Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells
.
Gastroenterology, 2007, Vol. 133, 4, p. 1240-1249
.
IF = 11.673
[ASEP]
invited speaker Mick Hastings, 2023
H. Illnerová receives Silver medal of Czech Senate, 2021
visit of dr. Jihwan Myung, 2019
Alena Sumová receives Vojtěch Náprstek's honorary medal of merit in the popularization of science
prof. Illnerová with prof. Reppert, 2013
Lecture of prof. Menaker, 2014
