Cutting-edge science for health

Functional Morphology

Functional Morphology Recording of electrophysiological activity from dorsal horn neurons in acute spinal cord slices with patch-clamp technique.

The main research interest of our department is to study mechanisms of pain and to explore new possibilities of pain treatment, especially in chronic states. Our experimental work is concentrated on the modulation of nociceptive information at the spinal cord level that is the relay center between the periphery and the higher brain areas. Our goal is to study these modulatory mechanisms in order to improve therapy for pain conditions, such as allodynia, hyperalgesia, neuropathic and cancer related pain. Our focus is on the role of TRPV1 receptors and inflammatory cytokines. In our research we use mainly electrophysiological, immunohistochemical and behavioral methods. In addition, we finalize another project directed towards the role of thyroid hormones (THs) and omega-3-polyunsaturated fatty acid (n-3 PUFA) in the physiology of cardiac and skeletal muscles. Models of hyper- and hypothyroid status are used to analyze potential influence of n-3 PUFA on the induced pathological changes. 

Obituary RNDr. Tomáš Soukup, CSc


Chemotherapy induced neuropathic pain

Scientists from the Department of Functional Morphology in collaboration with colleagues from The University of Texas showed that paclitaxel induced pain is mediated by TRPV1 and TLR4 receptors. More

Inhibition effect of NAPE at spinal cord level

N-acylphosphatidylethanolamine (NAPE), as the precursor of anandamide, an endogenous agonist of TRPV1 and cannabinoid receptors, could play a role in modulation of nociceptive signalization in the spinal cord. More



Kalynovska, Nataliia - Diallo, Michael - Paleček, Jiří . Losartan treatment attenuates the development of neuropathic thermal hyperalgesia induced by peripheral nerve injury in rats . Life Sciences 2019, 220(Mar 1), 147-155 . IF = 3.448 [ASEP] [ doi ]
Adámek, Pavel - Heleš, Mário - Paleček, Jiří . Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy . Neuropharmacology 2019, 146(Mar 1), 163-174 . IF = 4.367 [ASEP] [ doi ]
Torres-Pérez, J. V. - Adámek, Pavel - Paleček, Jiří - Vizcaychipi, M. - Nagy, I. - Varga, A. The NA(v)1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing . Journal of Molecular Medicine-Jmm 2018, roč. 96, 1, p. 75-84 . IF = 4.746 [ASEP] [ doi ]
Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Vaněčková, Ivana - Tribulová, N. - Soukup, Tomáš . Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status . Physiological Research 2018, roč. 67, 2, p. 307-315 . IF = 1.701 [ASEP]
Nerandžič, Vladimír - Mrózková, Petra - Adámek, Pavel - Špicarová, Diana - Nagy, I. - Paleček, Jiří . Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N‐arachidonoylphosphatidylethanolamine . British Journal of Pharmacology 2018, roč. 175, 12, p. 2322-2356 . IF = 6.583 [ASEP] [ doi ]

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Jiří Paleček, MD, PhD
head of the department
Mgr. Diana Špicarová, Ph.D.
deputy head of the department
RNDr. Gisela Zachařová
scientific technician
Mgr. Vladimír Nerandžič
PhD student
Mgr. Petra Mrózková
PhD student
Mgr. Nataliia Kalynovska
PhD student
Mgr. Pavel Adámek
PhD student
Bc. Dominika Šulcová
undergraduate student
Bc. Jakub Slepička
undergraduate student
Kateřina Kramerová
lab technician
Martina Pytlová
lab technician