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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Methodical approaches

In our research, we use mostly laboratory rats and mice including suitable transgenic models. Cardiac tolerance to injury caused by temporal coronary artery occlusion and reperfusion is studied in anesthetized open-chest animals, isolated perfused hearts are used to assess tolerance to injury due to global or regional ischemia/reperfusion, and isolated ventricular myocytes serve to analyze the effects of simulated anoxia/reoxygenation. As major manifestations of injury we evaluate the size of myocardial infarction, the incidence and severity of ventricular arrhythmias, the postischemic recovery of contractile function, and the viability of myocytes. Echocardiography and catheterization techniques are used to assess heart functions and hemodynamics. To study cardioprotective mechanisms we employ suitable pharmacological tools and biochemical analyses.

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People

RNDr. Jan Neckář, Ph.D.
Head of the Laboratory
   Prof. RNDr. František Kolář, CSc.
Deputy Head of the Laboratory
Prof. MUDr. David Sedmera, DSc.
Senior Researcher
Prof. MUDr. Bohuslav Ošťádal, DrSc.
Senior Researcher
MUDr. Ivana Ošťádalová, CSc.
Senior Researcher
Ing. František Papoušek, CSc.
Senior Researcher
RNDr. Markéta Hlaváčková, Ph.D.
Senior Researcher
  Olga Nováková
Senior Researcher
RNDr. Petra Alánová, Ph.D.
Postdoctoral Fellow
RNDr. Martina Gregorovičová, Ph.D.
Postdoctoral Fellow
  Mgr. Petra Kolesová, Ph.D.
Postdoctoral Fellow
MVDr. Veronika Olejníčková, Ph.D.
Postdoctoral Fellow

RNDr. Kristýna Holzerová, Ph.D.
Postdoctoral Fellow

Mgr. Jaroslav Hrdlička
PhD Student
Mgr. Daniel Benák
PhD Student

MUDr. Dmytro Semenovykh

PhD Student

 

Ing. Šárka Škutová

PhD Student

MUDr. Tereza Vavříková

PhD Student

 

Petr Kordač

Research Assistant

Ing. Miloslava Marková
Technician
Milana Pešková
Technician
Jarmila Svatůňková
Technician