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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Molecular Physiology of Bone

Laboratory of Molecular Physiology of Bone Left: μCT analysis of bone and osmium-stained bone marrow adipose tissue (BMAT) in chow (ND) and high-fat diet (HFD) mice. Right: Isolation protocol of bone marrow skeletal stem cells and their differentiation in osteoblasts (OB) and adipocytes (AD).

In obesity, lipids are accumulated in liver, muscle or cardiovascular system, instead of adipose tissue. Recent studies have shown that bones are also affected, leading to enhanced adipocyte formation in bone marrow (BMAT). Higher BMAT is often associated with bone fragility fractures, an overlooked complication affecting the quality of life. There is limited information on a physiological role of BMAT in relation to bone and whole body energy metabolism. The major focus of the department is on the characterization of the metabolic phenotype of BMAT and its contribution to bone homeostasis and whole body energy metabolism. The research will employ murine and human cellular systems, mice biomodels, clinical studies and molecular, bioanalytical and in vivo phenotyping techniques. It will be conducted within a broad international collaboration.

The department has been newly established in 2019, based on the 5-year "Start Up Research Program" financed by IPHYS.  

 

 

Achievements

Grants awarded to the Tencerova laboratory: 2021: 3-year Student research grant from GAUK (PI: Andrea Benova) 2020: 5-year EFSD/Novo Nordisk Foundation Future Leaders Award (PI: Michaela Tencerova) 2020: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2019: 5-year START UP Research program supported by IPHYS (PI: Michaela Tencerova)   More

Publications

Beňová; Andrea - Tencerová; Michaela . Obesity-Induced Changes in Bone Marrow Homeostasis . Frontiers in Endocrinology. 2020; 11(May 12)); 294 . IF = 3.644 [ASEP] [ doi ]

Article photogallery

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People

     

Mgr. Michaela Tencerová, Ph.D.

Head of the Laboratory

michaela.tencerova@fgu.cas.cz

   

Mgr. Andrea Beňová

PhD Student

   

RNDr. Michaela Ferenčáková, Ph.D.

Postdoctoral Fellow

Glenda Paola Aalquicer-Barrera, Ph.D.

Research Assistant

  

Lucie Svobodová, Ph.D.

Research Assistant

  

Binu Prakash, Ph.D.

Postdoctoral Fellow