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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Molecular Neurobiology

Laboratory of Molecular Neurobiology Left: GFP-labeled hippocampal granule cells (green), in utero electroporated. Middle: Dendrites (arrows) and dendritic spines (inset) of cortical pyramidal neurons (red) and their 3D model. Right: NFL antibody-stained peripheral neurons in E11.5 embryos.

Defects in signaling cascades are considered to contribute to many neurodevelopmental and neurodegenerative disorders, but the exact molecular mechanisms underlying the onset of these diseases are so far largely unknown. Using mouse models and primary neuron cultures, we focus on identification of genes, molecular mechanism and signaling cascades that regulate neuron polarization, axonal/dendritic growth and guidance in the developing nervous system, and their deregulation that leads to neurodevelopmental disorders as autism spectrum disorders, epilepsy or schizophrenia.

Our work focuses on:

  • the function of microtubule associated proteins of CRMP family and their isoforms in neural development
  • regulation of CRMP isoforms by prolyl isomerases during growth and guidance of axons/dendrites
  • the efect of tubulin pottranslational modifications and microtubule associated proteins on microtubule dynamics and cortical development in vitro and in vivo

Projects

Publications

Magiera, M. M. - Bodakuntla, S. - Žiak, Jakub - Lacomme, S. - Sousa, P. M. - Leboucher, S. - Hausrat, T. J. - Bosc, Ch. - Andrieux, A. - Kneussel, M. - Landry, M. - Calas, A. - Balaštík, Martin - Janke, C. Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport . EMBO Journal 2018, 37(23)), e100440 . IF = 11.227 [ASEP] [ doi ]
Hahnová, K. - Brabcová, I. - Neckář, Jan - Weissová, Romana - Svatoňová, Anna - Nováková, O. - Žurmanová, J. - Kalous, M. - Šilhavý, Jan - Pravenec, Michal - Kolář, František - Novotný, J. beta-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia . Journal of Physiological Sciences 2018, roč. 68, 4, p. 441-454 . IF = 3.341 [ASEP] [ doi ]
Zjablovskaja, Polina - Kardošová, Miroslava - Daněk, Petr - Angelisova, Pavla - Benoukraf, T. - Wurm, A.A. - Kalina, T. - Sian, S. - Balaštík, Martin - Delwel, R. - Brdička, Tomáš - Tenen, D.G. - Behre, G. - Fiore, F. - Malissen, B. - Hořejší, Václav - Alberich-Jorda, Meritxell . EVI2B is a C/EBP alpha target gene required for granulocytic differentiation and functionality of hematopoietic progenitors . Cell Death and Differentiation. 2017, roč. 24, 4, p. 705-716 . IF = 8.000 [ASEP] [ doi ]
Neckář, Jan - Svatoňová, Anna - Weissová, Romana - Drahota, Zdeněk - Zajíčková, Pavlína - Brabcová, I. - Kolář, D. - Alánová, Petra - Vašinová, Jana - Šilhavý, Jan - Hlaváčková, Markéta - Tauchmannová, Kateřina - Milerová, Marie - Ošťádal, Bohuslav - Červenka, L. - Žurmanová, J. - Kalous, M. - Nováková, Olga - Novotný, J. - Pravenec, Michal - Kolář, František . Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats . Clinical science. 2017, roč. 131, 9, p. 865-881 . IF = 5.220 [ASEP] [ doi ]
Balaštík, Martin - Zhou, X.Z. - Alberich-Jorda, M. - Weissová, Romana - Žiak, Jakub - Pazyra-Murphy, M.F. - Cosker, K.E. - Machoňová, O. - Kozmiková, I. - Chen, CH. - Pastorino, L. - Asara, J.M. - Cole, A. - Sutherland, C. - Segal, R. A. - Lu, K.P. Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons . Cell Reports. 2015, Vol. 13, 4, p. 812-828 . IF = 7.87 [ASEP] [ doi ]

Article photogallery

The entire photogallery

People

  Martin Balaštík, Ph.D.
Head of the Laboratory
  Mgr. Romana Weissová
PhD Student/Deputy Head of the Laboratory
 

Mgr. Barbora Eliášová

PhD Student

  Mgr. Marie Kleisnerová
PhD Student
  MUDr. Jakub Žiak
PhD Student
 

Mgr. Peter Búran

PhD Student

 

Michaela Rusková

Undergraduate Student