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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Developmental Epileptology

Laboratory of Developmental Epileptology

The research at our Laboratory focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.

Our primary research topics are:

  • Consequences of brain injury during early stages of the brain development
  • Mechanisms responsible for seizure initiation and termination.
  • Impact of seizures on the developing brain
  • Development of new diagnostic techniques of epilepsy
  • Cognitive and behavioural consequences of epilepsy
  • The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
  • Impact of antiepileptic therapy of the brain development
  • Age-specific mechanisms of seizure initiation and propagation

Projects

Consequences of early brain-damage and prevention of development of epilepsy and functional damage

Brain-damaging insult triggers a cascade of molecular, cellular and structural changes that eventually lead to behavioral alterations and development of epilepsy. The response to the particular brain insult is highly age-dependent. Our aim is to study effects of early insults on the brain development at the molecular, cellular, and circuitry levels (maturation of receptors or ionic channel structures, vascularisation, myelination, circuitry maturation, etc.) and consequently on maturation of more complex brain functions (cognitive functions, sensorimotor skills, social and emotional behavior, brain excitability, etc.). Results of our research can be used to develop age specific pharmacological strategies for prevention of epilepsy development and disturbances of brain function.   More

Achievements

Publications

Svoboda, Jan - Litvinec, Andrej - Kala, David - Pošusta, Antonín - Vávrová, Lenka - Jiruška, Přemysl - Otáhal, Jakub . Strain Differences in Intraluminal Thread Model of Middle Cerebral Artery Occlusion in Rats . Physiological Research 2019, 68(1), 37-48 . IF = 1.655 [ASEP] [ doi ]
Murden; S. - Borbélyová; V. - Laštůvka; Z. - Mysliveček; J. - Otáhal; Jakub - Riljak; V. Gender Differences Involved in the Pathophysiology of the Perinatal Hypoxic-Ischemic Damage . Physiological Research. 2019; 68(Suppl.3); S207-S2017 . IF = 1.655 [ASEP] [ doi ]
Mikulecká; Anna - Druga; Rastislav - Stuchlík; Aleš - Mareš; Pavel - Kubová; Hana . Comorbidities of early-onset temporal epilepsy: Cognitive; social; emotional; and morphologic dimensions . Experimental Neurology. 2019; 320(Oct)); UNSP 113005 . IF = 4.691 [ASEP] [ doi ]
Mareš; Pavel - Folbergrová; Jaroslava - Haugvicová; Renata - Kubová; Hana . Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats? . Physiological Research. 2019; 68(Suppl.3); S361-S366 . IF = 2.208 [ASEP] [ doi ]
Mareš, Pavel - Kubová, Hana . Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats . Epilepsy Research 2019, 149(Jan), 17-20 . IF = 1.655 [ASEP] [ doi ]

People

Doc. PharmDr. Hana Kubová, DrSc.
Head of the Laboratory
Doc. MUDr. Jakub Otáhal, Ph.D.
Deputy Head of the Laboratory
RNDr. Jaroslava Folbergrová, DrSc.
Senior Researcher
Prof. MUDr. Přemysl Jiruška, Ph.D.
Senior Researcher
Prof. MUDr. Pavel Mareš, DrSc.
Senior Researcher
RNDr. Nina Mikulecká, Ph.D.
Senior Researcher
Mgr. Grygoriy Tsenov, Ph.D.
Senior Researcher
MUDr. Petr Fábera 
PhD Student
Ing. Jan Kudláček​ 
PhD Student
Ing. et Ing. Antonín Pošusta​ 
PhD Student
Mgr. Ewa Szczurowska​ 
PhD Student
Mgr. Libor Uttl​ 
PhD Student
Ing. Pavel Vlk 
PhD Student
Bc. Lubica Demeterová 
Pregraduate Student
Bc. Kateřina Vondráková​ 
Pregraduate Student
  Blanka Čejková​​ 
Technician
Eva Lažková​ 
Technician
Irinka Necheva​​ 
Technician
Ivana Rabasová​​​ 
Personal Assistant
  prof. MUDr. Rastislav Druga, DrSc.
visiting researcher
Thuy Hua
visiting researcher