Learning about threats from observing others has significant adaptive value, but excessive responding to observed threats interferes with other essential functions and in humans causes trauma-related disorders. To elucidate neural underpinnings of observational fear, we conditioned mice to an auditory cue by watching a demonstrator undergo cue-shock pairings. We found input to dorsomedial prefrontal cortex (dmPFC) from basolateral amygdala (BLA) and ventral hippocampal (vHPC) respectively promote and constrain observer freezing. Additionally, we found dmPFC neurons independently code observed and directly experienced threat, and that dmPFC projections to midbrain periaqueductal gray (PAG) signal the dynamic transfer of threat information from demonstrator-to-observer to limit freezing in observers. Our findings reveal how coordination and competition between long-range brain circuits is computed by dmPFC to calibrate an appropriate response to observed threat.
Link for on-line lecture: https://cesnet.zoom.us/j/95696147174
To launch the online seminar, you will have to install the ZOOM client (link HERE) or ZOOM will install automatically when launching the seminar for the first time. If ZOOM client does not work, it is possible to use ZOOM in the browser by clicking on "Join from web browser". If you have any troubles with ZOOM, please contact the IT department.
We kindy ask on-line participants to follow these rules.
IPHYS contact person: Jan Jakubík, jan.jakubík@fgu.cas.cz