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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Modulation of nociceptive signaling at spinal cord level

Laboratory of Functional Morphology

PhD Project: Modulation of nociceptive signaling at spinal cord level

The main research interest of our department is to study mechanisms of pain and to explore new possibilities of pain treatment, especially in chronic states. Our experimental work is concentrated on the modulation of nociceptive information at the spinal cord level that is the relay center between the periphery and higher brain areas. Our goal is to study these modulatory mechanisms in order to improve therapy for pain conditions, such as allodynia, hyperalgesia, neuropathic and cancer related pain. This project will be focused on modulation of synaptic transmission at the spinal cord level. Lately we are interested in the role of TRPV1 receptors, cannabinoids, opioids and inflammatory cytokines in this process. In our research we use mainly electrophysiological, imaging, immunohistochemical and behavioral methods.

Candidate Requirements: Candidates should have a Masters' degree in biological, medical or chemical sciences, or be due to complete their studies in this academic year.  Experience in physiology, cell biology, molecular biology or electrophysiology techniques would be an advantage. Candidates should be fluent in Czech or English.  

Supervisor:  Jiri Palecek, M.D., Ph.D.,

Selected relevant publications:

D. Spicarova, P. Adamek, N. Kalynovska, P. Mrozkova, J. Palecek, TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia. Neuropharmacology 81:75-84, 2014 IF=4.82

Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison.DS, Cata,J.P. Sapire,K. Zhang,H. Kennamer, R. M. Jawad, A.B. - Ghetti, A. - Yan, J. - Paleček, J.  Dougherty, P. M. The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4. J Neurosci. 2015;35(39):13487-13500. IF=6.34

Mrózková,P, Špicarová,D - Paleček, J. Hypersensitivity Induced by Activation of Spinal Cord PAR2 Receptors Is Partially Mediated by TRPV1 Receptors. PLoS ONE. 2016,11,10,  e0163991 . IF = 3.1

Nerandzic V, Mrozkova P, Adamek P, Spicarova D, Nagy I, Palecek J. Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N-arachidonoylphosphatidylethanolamine. British Journal of Pharmacology 2018, roč. 175, 12, p. 2322-2356 . IF = 6.8

Torres-Pérez JV, Adamek P, Palecek J, Vizcaychipi M, Nagy I, Varga A. The NAv1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing. . Journal of Molecular Medicine-Jmm 2018, roč. 96, 1, p. 75-84 . IF = 4.9

Adamek P, Heles M, Palecek J, Mechanical allodynia and enhanced responses to capsaicin are mediated by PI3K in a paclitaxel model of peripheral neuropathy. Neuropharmacology. 2019, 146: 163-174,  IF=4.3