Prof. Henry Jay Forman

University of Southern California, USA

Nuclear factor erythroid 2-related factor (Nrf2) is the master transcription factor regulating the basal and inducible expression of antioxidant/detoxifying genes. With aging, Nrf2 signaling has increased basal activity but declines in response to electrophiles from air pollution nanoparticles as well as the electrophile, sulforaphane. We demonstrated that aging-related changes of Nrf2 signaling were accompanied by an increased expression of Bach1 and c-Myc, repressors of Nrf2 signaling, in both mouse organs and in primary human bronchial epithelial (HBE) cells from old versus young donors. We examined the effect of silencing Bach1 in HBE cells and found differential effects on Nrf2-regulated genes in cells from young and old donors.

Kontaktní osoba v FGÚ: Martin Jabůrek, martin.jaburek@fgu.cas.cz