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Developmental Cardiology

Developmental Cardiology

Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:


  • high cardiac tolerance to injury early ontogeny,
  • increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
  • permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
  • and altered cardiac tolerance associated with various pathological states.


Developmental aspects of cardiac ischemic tolerance

The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. More

Cardiac ischemic tolerance in systemic hypertension

Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance. More

Cardioprotective mechanism of chronic hypoxia

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. More


Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A. Wars2 is a determinant of angiogenesis . Nature Communications. 2016, roč. 7, Jul, p. 12061 . IF = 11.329 [ASEP] [ doi ]
Vrbacký, Marek - Kovalčíková, Jana - Chawengsaksophak, Kallayanee - Beck, Inken - Mráček, Tomáš - Nůsková, Hana - Sedmera, David - Papoušek, František - Kolář, František - Sobol, Margaryta - Hozák, Pavel - Sedláček, Radislav - Houštěk, Josef . Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice . Human Molecular Genetics. 2016, roč. 25, 21, p. 4674-4685 . IF = 5.985 [ASEP] [ doi ]
Vostárek, František - Svatůňková, Jarmila - Sedmera, David . Acute temperature effects on function of the chick embryonic heart . Acta Physiologica. 2016, roč. 217, 4, p. 276-286 . IF = 4.066 [ASEP] [ doi ]
Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František . Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice . Physiological Research. 2016, roč. 65, 1, p. 33-42 . IF = 1.643 [ASEP]
Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload . Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367 . IF = 4.031 [ASEP] [ doi ]


Institute of Physiology AS CR, v.v.i.
Department of Developmental Cardiology

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 559
fax. +420 241 062 125


  Prof. RNDr. František Kolář, CSc.
head of the department
  RNDr. Jan Neckář, Ph.D.
deputy head of the department
  Prof. MUDr. Bohuslav Ošťádal, DrSc.
senior researcher
  MUDr. Ivana Ošťádalová, CSc.
senior researcher
  Ing. František Papoušek, CSc.
senior researcher
  Mgr. Markéta Hlaváčková, Ph.D.
senior researcher
  RNDr. Marie Milerová
senior researcher
  Mgr. Kristýna Macháčková (Slámová)
PhD student
  Mgr. Petra Mandíková
PhD student
  Mgr. Anna Chytilová
PhD student
  Mgr. Jaroslav Hrdlička
PhD student
  Ing. Miloslava Marková
  Milana Pešková
  Jana Vašínová