Department of bioenergetics, Institute of Physiology CAS is looking for highly motivated postdoctoral fellow with Ph.D. or equivalent degree to work on GA CR (Czech Science Foundation) funded project:
Mitochondrial glycerol-3-phosphate dehydrogenase as a target for anti-tumour therapies
Mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mGPDH) is inducible and highly tissue/cell specific enzyme typically active in glycolytic cells. Main aim of this project is to verify mGPDH as a potential druggable target in tumour cells and confidently identify those cancer cell lines which are negatively affected by traditional and novel mGPDH inhibitors. Project will include work on tumour cell lines, biochemical characterisation of inhibitors’ mode of action and data mining for tumour types, which are dependent on mGPDH.
Successful candidate will report to project’s PI (Dr Alena Pecinova) and the head of department (Dr Tomas Mracek). You will get the opportunity to become a member of our young and dynamic team based in state of the art facilities within the biomedical campus of the Czech Academy of Sciences located at the outskirts of Prague. For details about the department, you can check our webpage: http://fgu.cas.cz/en/departments/bioenergetics
Applicants should fulfil following criteria:
Conditions of the contract:
The applications should be sent to tomas.mracek@fgu.cas.cz and contain: