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Laboratory of Biomaterials and Tissue Engineering

Laboratory of Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.



Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More


Vondrášek; David - Hadraba; Daniel - Přibyl; J. - Eckhardt; Adam - Ošťádal; M. - Lopot; F. - Jelen; K. - Doubková; Martina - Knitlová; Jarmila - Novotný; T. - Janáček; Jiří . Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue . Microscopy and Microanalysis. 2023; 29(1); 265-272 . IF = 4.099 [ASEP] [ doi ]
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Doc. MUDr. Lucie Bačáková, CSc.
Head of the Laboratory

Mgr. Elena Filová, Ph.D.
Deputy Head of the Laboratory


Ing. Irena Vacková, CSc.

Věra Lisá, prom. biol.
Mgr. Jana Racková (nee. Lišková), Ph.D.
Researcher (maternity leave)
RNDr. Jana Musílková, CSc.
RNDr. Lubica Staňková (nee. Grausová), Ph.D.
RNDr. Lucie Svobodová, Ph.D.

Mgr. Antonín Brož, Ph.D.

Ing. Markéta Zikmundová, Ph.D.
Postdoctoral Researcher (maternity leave)


MUDr. Jaroslav Chlupáč, Ph.D.
Postdoctoral Researcher
Mgr. Ivana Němčáková (nee. Kopová), Ph.D.
Postdoctoral Researcher (maternity leave)
Ing. Jana Zárubová (nee. Havlíková), Ph.D.
Postdoctoral Researcher
MUDr. Martina Trávníčková, Ph.D.
Postdoctoral Researcher
Mgr. Martina Doubková
PhD Student

Mgr. Júlia Pajorová
PhD Student

Mgr. Antonín Sedlář
PhD Student

Mgr. Šimon Pražák
PhD Student

  MSc. Marina Malić
PhD Student
  MSc. Yu-Chieh Wu
PhD Student
Mgr. Jarmila Knitlová
PhD Student

Ing. Roman Matějka
Research Assistant


Ing. Jana Štěpanovská
Research Assistant

Jana Voborníková
Administrative Worker
Ivana Zajanová
  Bc. Kateřina Pokorná
MSc. student