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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Biomaterials and Tissue Engineering

Laboratory of Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More

Publications

Vandrovcová; Marta - Tolde; Z. - Vaněk; Přemysl - Nehasil; V. - Doubková; Martina - Trávníčková; Martina - Drahokoupil; Jan - Buixaderas; Elena - Borodavka; Fedir - Nováková; J. - Bačáková; Lucie . Beta-Titanium Alloy Covered by Ferroelectric Coating-Physicochemical Properties and Human Osteoblast-Like Cell Response . Coatings. 2021; 11(2)); 210 . IF = 2.436 [ASEP] [ doi ]
Trávníčková; Martina - Kasálková-Slepičková; N. - Sedlář; Antonín - Molitor; M. - Musílková; Jana - Slepička; P. - Švorčík; V. - Bačáková; Lucie . Differentiation of adipose tissue-derived stem cells towards vascular smooth muscle cells on modified poly(L-lactide) foils . Biomedical Materials. 2021; 16(2)); 025016 . IF = 3.174 [ASEP] [ doi ]
Steinerová; Marie - Matějka; Roman - Štěpanovská; Jana - Filová; Elena - Staňková; Ľubica - Rysová; M. - Martinová; L. - Dragounová; Helena - Domonkos; Mária - Artemenko; Anna - Babchenko; Oleg - Otáhal; M. - Bačáková; Lucie - Kromka; Alexander . Human osteoblast-like SAOS-2 cells on submicron-scale fibers coated with nanocrystalline diamond films . Materials Science & Engineering C-Materials for Biological Applications. 2021; 121(Feb)); 111792 . IF = 5.880 [ASEP] [ doi ]
Sedlář; Antonín - Trávníčková; Martina - Matějka; Roman - Pražák; Šimon - Mészáros; Zuzana - Bojarová; Pavla - Bačáková; Lucie - Křen; Vladimír - Slámová; Kristýna . Growth Factors VEGF-A(165) and FGF-2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation . International Journal of Molecular Sciences. 2021; 22(4)); 1843 . IF = 4.556 [ASEP] [ doi ]
Filová; Elena - Steinerová; Marie - Trávníčková; Martina - Knitlová; Jarmila - Musílková; Jana - Eckhardt; Adam - Hadraba; Daniel - Matějka; Roman - Pražák; Šimon - Štěpanovská; Jana - Kučerová; Johanka - Riedel; Tomáš - Brynda; Eduard - Lodererová; A. - Honsová; E. - Pirk; J. - Koňařík; M. - Bačáková; Lucie . Accelerated in vitro recellularization of decellularized porcine pericardium for cardiovascular grafts . Biomedical Materials. 2021; 16(2)); 025024 . IF = 3.174 [ASEP] [ doi ]
Dušková-Smrčková; Miroslava - Zavřel; J. - Bartoš; M. - Kaberova; Zhansaya - Filová; Elena - Zárubová; Jana - Šlouf; Miroslav - Michálek; Jiří - Vampola; T. - Kubies; Dana . Communicating macropores in PHEMA-based hydrogels for cell seeding: probabilistic open pore simulation and direct micro-CT proof . Materials and Design. 2021; 198(15 January)); 109312 . IF = 6.289 [ASEP] [ doi ]
Zikmundová; Markéta - Vereshaka; M. - Kolářová; K. - Pajorová; Julia - Švorčík; V. - Bačáková; Lucie . Effects of Bacterial Nanocellulose Loaded with Curcumin and Its Degradation Products on Human Dermal Fibroblasts . Materials. 2020; 13(21)); 4759 . IF = 3.057 [ASEP] [ doi ]
Zárubová; Jana - Hasani-Sadrabadi; M. M. - Bačáková; Lucie - Li; S. Nano-in-Micro Dual Delivery Platform for Chronic Wound Healing Applications . Micromachines. 2020; 11(2)); 158 . IF = 2.523 [ASEP] [ doi ]
Trávníčková; Martina - Vandrovcová; Marta - Filová; Elena - Steinerová; Marie - Racková; Jana - Kocourek; Tomáš - Bartová; J. - Suchý; Tomáš - Žaloudková; Margit - Jelínek; Miroslav - Bačáková; Lucie . Effect of diamond-like carbon doped with chromium on cell differentiation; immune activation and apoptosis . European Cells and Materials. 2020; 40; 276-302 . IF = 3.741 [ASEP] [ doi ]
Trávníčková; Martina - Pajorová; Julia - Zárubová; Jana - Kročilová; Nikola - Molitor; M. - Bačáková; Lucie . The Influence of Negative Pressure and of the Harvesting Site on the Characteristics of Human Adipose Tissue-Derived Stromal Cells from Lipoaspirates . Stem Cells International. 2020; 2020(Feb 10)); 1016231 . IF = 3.869 [ASEP] [ doi ]

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People

Doc. MUDr. Lucie Bačáková, CSc.
Head of the Laboratory

Mgr. Elena Filová, Ph.D.
Deputy Head of the Laboratory

RNDr. Marta Vandrovcová, Ph.D.
Researcher

Věra Lisá, prom. biol.
Researcher
Mgr. Jana Racková (nee. Lišková), Ph.D.
Researcher (maternity leave)
RNDr. Jana Musílková, CSc.
Researcher
RNDr. Lubica Staňková (nee. Grausová), Ph.D.
Researcher

Mgr. Antonín Brož, Ph.D.
Postdoctoral Researcher

Ing. Markéta Zikmundová, Ph.D.
Postdoctoral Researcher
MUDr. Jaroslav Chlupáč, Ph.D.
Postdoctoral Researcher
Mgr. Ivana Němčáková (nee. Kopová), Ph.D.
Postdoctoral Researcher
Ing. Jana Zárubová (nee. Havlíková), Ph.D.
Postdoctoral Researcher
  Andreu Blanquer Jerez, Ph.D.
Postdoctoral Researcher
Mgr. Martina Doubková
PhD Student

Mgr. Júlia Pajorová
PhD Student

MUDr. Martina Trávníčková
PhD Student

Mgr. Antonín Sedlář
PhD Student
 

Bc. Šimon Pražák

PhD Student

 

Bc. Bedřich Hádek

Research Assistant

 

Ing. Roman Matějka

Research Assistant

 

Ing. Jana Štěpanovská

Research Assistant

Jana Voborníková
Administrative Worker
Mgr. Jarmila Knitlová
Technician Biologist
Ivana Zajanová
Technician