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Laboratory of Biomaterials and Tissue Engineering

Laboratory of Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More

Publications

Vondrášek; David - Hadraba; Daniel - Přibyl; J. - Eckhardt; Adam - Ošťádal; M. - Lopot; F. - Jelen; K. - Doubková; Martina - Knitlová; Jarmila - Novotný; T. - Janáček; Jiří . Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue . Microscopy and Microanalysis. 2023; 29(1); 265-272 . IF = 2.8 [ASEP] [ doi ]
Táborská; Johanka - Blanquer; Andreu - Brynda; Eduard - Filová; Elena - Stiborová; Lenka - Jenčová; V. - Havlíčková; K. - Riedelová; Zuzana - Riedel; Tomáš . PLCL/PCL dressings with platelet lysate and growth factors embedded in fibrin for chronic wound regeneration . International Journal of Nanomedicine. 2023; 18(3 February); 595-610 . IF = 8.0 [ASEP] [ doi ]
Štěpánková; K. - Mareková; D. - Kubášová; K. - Sedláček; R. - Turnovcová; K. - Vacková; Irena - Kubinová; Šárka - Makovický; P. - Petrovičová; M. - Kwok; J. C. F. - Jendelová; P. - Urdzíková; L. 4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats . International Journal of Molecular Sciences. 2023; 24(4)); 3799 . IF = 5.6 [ASEP] [ doi ]
Skvortsova; A. - Trelin; A. - Sedlář; Antonín - Erzina; M. - Trávníčková; Martina - Svobodová; Lucie - Kolská; Z. - Siegel; J. - Bačáková; Lucie - Švorčík; V. - Lyutakov; O. SERS-CNN approach for non-invasive and non-destructive monitoring of stem cell growth on a universal substrate through an analysis of the cultivation medium . Sensors and Actuators B - Chemical. 2023; 375(15 January)); 132812 . IF = 8.4 [ASEP] [ doi ]
Rogulska; Olena - Havelková; Jarmila - Petrenko; Yuriy . Cryopreservation of Organoids . Cryo-letters. 2023; 44(2); 65-75 . IF = 1.0 [ASEP] [ doi ]
Flis; A. - Trávníčková; Martina - Koper; F. - Knap; K. - Kasprzyk; W. - Bačáková; Lucie - Pamula; E. Poly(octamethylene citrate) Modified with Glutathione as a Promising Material for Vascular Tissue Engineering . Polymers. 2023; 15(5)); 1322 . IF = 5.0 [ASEP] [ doi ]
Filová; Elena - Šupová; Monika - Eckhardt; Adam - Vrbacký; Marek - Blanquer; Andreu - Trávníčková; Martina - Knitlová; Jarmila - Suchý; Tomáš - Rýglová; Šárka - Braun; Martin - Burdíková; Z. - Schätz; M. - Jenčová; V. - Lisnenko; M. - Běhálek; L. - Procházková; R. - Sedláček; R. - Kubasová; K. - Bačáková; Lucie . Adipose-Derived Stem Cells in Reinforced Collagen Gel: A Comparison between Two Approaches to Differentiation towards Smooth Muscle Cells . International Journal of Molecular Sciences. 2023; 24(6)); 5692 . IF = 5.6 [ASEP] [ doi ]
Berounský; K. - Vacková; Irena - Vištejnová; L. - Malečková; A. - Havránková; J. - Klein; P. - Kolinko; Y. - Petrenko; Yuriy - Pražák; Šimon - Hanák; F. - Přidal; J. - Havlas; V. Autologous Mesenchymal Stromal Cells Immobilized in Plasma-Based Hydrogel for the Repair of Articular Cartilage Defects in a Large Animal Model . Physiological Research. 2023; 72(4); 485-495 . IF = 2.1 [ASEP] [ doi ]
Zárubová; Jana - Hasani-Sadrabadi; M. M. - Norris; S. C. P. - Majedi; F. S. - Xiao; C. - Kasko; A. M. - Li; S. Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells . Small. 2022; 18(50)); 2203515 . IF = 13.3 [ASEP] [ doi ]
Zárubová; Jana - Hasani-Sadrabadi; M. M. - Dashtimoghadam; E. - Zhang; X. - Ansari; S. - Li; S. - Moshaverinia; A. Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration . Advanced Healthcare Materials. 2022; 11(12)); 2102593 . IF = 10.0 [ASEP] [ doi ]

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People

Doc. MUDr. Lucie Bačáková, CSc.
Head of the Laboratory

Mgr. Elena Filová, Ph.D.
Deputy Head of the Laboratory

 

Ing. Irena Vacková, CSc.
Researcher

Věra Lisá, prom. biol.
Researcher
RNDr. Jana Musílková, CSc.
Researcher
RNDr. Lubica Staňková (nee. Grausová), Ph.D.
Researcher
RNDr. Lucie Svobodová, Ph.D.
Researcher

Mgr. Antonín Brož, Ph.D.
Researcher

Ing. Markéta Zikmundová, Ph.D.
Postdoctoral Researcher (maternity leave)

 

MUDr. Jaroslav Chlupáč, Ph.D.
Postdoctoral Researcher
Mgr. Ivana Němčáková (nee. Kopová), Ph.D.
Postdoctoral Researcher (maternity leave)
Ing. Jana Zárubová (nee. Havlíková), Ph.D.
Postdoctoral Researcher
MUDr. Martina Trávníčková, Ph.D.
Postdoctoral Researcher
Mgr. Júlia Tomšů, Ph.D.
Postdoctoral Researcher
Mgr. Martina Doubková
PhD Student
Mgr. Antonín Sedlář
PhD Student

Mgr. Šimon Pražák
PhD Student

  MSc. Marina Malić
PhD Student
  MSc. Yu-Chieh Wu
PhD Student
Mgr. Jarmila Knitlová
PhD Student
Ivana Zajanová
Technician
  Bc. Terézia Futóová
MSc. student
  Bc. Andrea Hejdová
MSc. student
  Adriena Přitasilová
BSc. student