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Laboratory of Epithelial Physiology

Laboratory of Epithelial Physiology Localization of the enzyme 11β-hydroxysteroid dehydrogenase type 1 in mouse colon stained with anti-11HSD1 antibody (A) and negative control (B).

Our research focuses on gastrointestinal (GI) physiology and pathophysiology and on understanding how complex GI functions are influenced by hormonal (corticosteroids) and environmental factors (stress, food, microbiota). Our work uses various strains of rats and mice, including germ-free animals and animal models of colitis and acute and chronic stress. In particular, we address the questions:

  • Host - gut microbiome interactions in neuroendocrine regulatory pathways
  • Regulation of intestinal transport
  • Local metabolism of glucocorticoids

Publications

Vagnerová; Karla - Jágr; M. - Mekadim; Chahrazed - Ergang; Peter - Sechovcová; Hana - Vodička; Martin - Olša Fliegerová; Kateřina - Dvořáček; V. - Mrázek; Jakub - Pácha; Jiří . Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress . Scientific Reports. 2023; 13(1)); 7278 . IF = 4.6 [ASEP] [ doi ]
Soták; M. - Casselbrant; A. - Rath; E. - Zietek; T. - Strömstedt; M. - Adingupu; D. D. - Karlsson; D. - Fredin; M. F. - Ergang; Peter - Pácha; Jiří - Batorsky; A. - Alpers; Ch. E. - Börgeson; E. - Hansen; P. B. L. - Ericsson; A. - Granqvist; A. B. - Wallenius; V. - Fändriks; L. - Unwin; R. J. Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity . Life Sciences. 2021; 267(Feb 15)); 118974 . IF = 6.780 [ASEP] [ doi ]
Pácha; Jiří - Balounová; Kateřina - Soták; M. Circadian regulation of transporter expression and implications for drug disposition . Expert Opinion on Drug Metabolism & Toxicology. 2021; 17(4); 425-439 . IF = 4.936 [ASEP] [ doi ]
Krausová; Alžběta - Burešová; Petra - Sarnová; Lenka - Oyman-Eyrilmez; Gizem - Škarda; J. - Wohl; P. - Bajer; L. - Sticová; E. - Bartoňová; L. - Pácha; Jiří - Koubková; Gizela - Procházka; Jan - Sporrer; M. - Durrbeck; C. - Stehlíková; Zuzana - Vít; M. - Ziolkowska; N. - Sedláček; Radislav - Jirák; D. - Kverka; Miloslav - Wiche; G. - Fabry; B. - Kořínek; Vladimír - Gregor; Martin . Plectin ensures intestinal epithelial integrity and protects colon against colitis . Mucosal Immunology. 2021; 14(3); 691-702 . IF = 9.020 [ASEP] [ doi ]
Ergang; Peter - Vagnerová; Karla - Hermanová; Petra - Vodička; Martin - Jágr; M. - Šrůtková; Dagmar - Dvořáček; V. - Hudcovic; Tomáš - Pácha; Jiří . The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine . International Journal of Molecular Sciences. 2021; 22(8)); 4229 . IF = 6.208 [ASEP] [ doi ]
Zemanová; N. - Anzenbacher; P. - Zapletalová; I. - Jourová; L. - Hermanová; Petra - Hudcovic; Tomáš - Kozáková; Hana - Vodička; Martin - Pácha; Jiří - Anzenbacherová; E. The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice . Scientific Reports. 2020; 10(1)); 8529 . IF = 4.379 [ASEP] [ doi ]
Vodička; Martin - Vavřínová; Anna - Mikulecká; Anna - Zicha; Josef - Behuliak; Michal . Hyper-reactivity of HPA axis in Fischer 344 rats is associated with impaired cardiovascular and behavioral adaptation to repeated restraint stress . STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS. 2020; 23(6); 667-677 . IF = 3.493 [ASEP] [ doi ]
Kroupová; Petra - van Schothorst; E. M. - Keijer; J. - Bunschoten; A. - Vodička; Martin - Irodenko; Ilaria - Oseeva; Marina - Žáček; P. - Kopecký; Jan - Rossmeisl; Martin - Horáková; Olga . Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice . Nutrients. 2020; 12(7)); 2037 . IF = 5.717 [ASEP] [ doi ]
Balounová; Kateřina - Soták; Matúš - Ergang; Peter - Vodička; Martin - Vagnerová; Karla - Pácha; Jiří . Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa . Mechanisms of Ageing and Development. 2020; 190(Sep)); 111317 . IF = 5.432 [ASEP] [ doi ]
Vavřínová; Anna - Behuliak; Michal - Bencze; Michal - Vodička; Martin - Ergang; Peter - Vaněčková; Ivana - Zicha; Josef . Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors . Hypertension Research. 2019; 42; 1872-1882 . IF = 2.941 [ASEP] [ doi ]
Vagnerová; Karla - Vodička; Martin - Hermanová; Petra - Ergang; Peter - Šrůtková; Dagmar - Klusoňová; Petra - Balounová; Kateřina - Hudcovic; Tomáš - Pácha; Jiří . Interactions Between Gut Microbiota and Acute Restraint Stress in Peripheral Structures of the Hypothalamic–Pituitary–Adrenal Axis and the Intestine of Male Mice . Frontiers in Immunology. 2019; 10); 2655 . IF = 5.085 [ASEP] [ doi ]
Vagnerová; Karla - Ergang; Peter - Soták; Matúš - Balounová; Kateřina - Kvapilová; Pavlína - Vodička; Martin - Pácha; Jiří . Diurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy . Comparative Biochemistry and Physiology Part C. 2019; 226(Dec)); 108607 . IF = 2.892 [ASEP] [ doi ]
Jágr, Michal - Ergang, Peter - Pataridis, Statis - Kolrosová, M. - Bartoš, M. - Mikšík, Ivan . Proteomic analysis of dentin-enamel junction and adjacent protein-containing enamel matrix layer of healthy human molar teeth . European Journal of Oral Sciences 2019, 127(2), 112-121 . IF = 2.220 [ASEP] [ doi ]
Vodička, Martin - Ergang, Peter - Hrnčíř, Tomáš - Mikulecká, Anna - Kvapilová, Pavlína - Vagnerová, Karla - Šestáková, Blanka - Fajstová, Alena - Hermanová, Petra - Hudcovic, Tomáš - Kozáková, Hana - Pácha, Jiří . Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress . Brain Behavior and Immunity 2018, 73(Oct 2018), 615-624 . IF = 6.170 [ASEP] [ doi ]
Kolínská, Jiřina - Zákostelecká, Marie - Zemanová, Zdeňka - Lisá, Věra - Goliáš, Jaroslav - Kozáková, Hana - Dvořák, B. Cellular differentiation of non-transformed intestinal epithelial cells is regulated by Lactobacillus rhamnosus and L. casei strains . Physiological Research 2018, roč. 67, 2, p. 261-273 . IF = 1.701 [ASEP]

Article photogallery

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People

 

Prof. RNDr. Jiří Pácha, DrSc.              

Head of the Laboratory 

  Ing. Peter Ergang, Ph.D.
Senior Researcher
  Ing. Karla Vágnerová, Ph.D.
Senior Researcher
  Mgr. Martin Vodička, Ph.D
Postdoctoral Fellow
  Ivana Muricová
Technician