The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Cardiovascular effects of new antidiabetics – gliflozins in model of experimental hypertension and chronic heart failure
- Central and peripheral mechanisms of blood pressure regulation
- Role of sympathetic and parasympathetic nervous system in cardiovascular diseases
- Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).
Projects
Achievements
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Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Zicha; Josef - Řezáčová; Lenka - Vaněčková; Ivana
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Nitric Oxide and Salt Resistance in Dahl Rats: No Role of Inducible NO Synthase
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Physiological Research. 2023; 72(1); 123-127
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IF = 2.1
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doi
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Strnadová; V. - Karnošová; A. - Blechová; M. - Neprašová; B. - Holá; L. - Němcová; A. - Myšková; A. - Sýkora; D. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies
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Neuropeptides. 2023; 98(April)); 102319
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IF = 2.9
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Rauchová; Hana - Hojná; Silvie - Kadlecová; Michaela - Vaněčková; Ivana - Chao; YM. - Chan; J. Y. H. - Zicha; Josef
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Sex differences in blood pressure; free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages
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Physiological Research. 2023; 72(2); 167-175
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IF = 2.1
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doi
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Piťha; J. - Vaněčková; Ivana - Zicha; Josef
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Hypertension after the Menopause: What Can We Learn from Experimental Studies?
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Physiological Research. 2023; 72(Suppl.2); 91-112
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IF = 2.1
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doi
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Pelantová; H. - Tomášová; P. - Šedivá; B. - Neprašová; B. - Mráziková; L. - Kuneš; Jaroslav - Železná; B. - Maletínská; L. - Kuzma; M.
Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis
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Metabolites. 2023; 13(4)); 552
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IF = 4.1
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doi
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Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance
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Nutrients. 2023; 15(2)); 280
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IF = 5.9
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doi
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Kuneš; Jaroslav - Hojná; Silvie - Mráziková; L. - Montezano; A. - Touyz; R.M. - Maletínská; L.
Obesity; Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms
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Physiological Research. 2023; 72(Suppl.2); 73-90
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IF = 2.1
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doi
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Karnošová; A. - Strnadová; V. - Železná; B. - Kuneš; Jaroslav - Kašpárek; P. - Maletínská; L.
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
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Clinical science. 2023; 137(10); 847-862
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IF = 6.0
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doi
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Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula
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Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157
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IF = 7.5
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doi
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Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension
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Journal of Hypertension. 2023; 41(1); 99-114
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IF = 4.9
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
