Obesity and type 2 diabetes accompanied by increased accumulation of bone marrow adipose tissue (BMAT) affect bone homeostasis. Using anti-diabetic drugs such as thiazolidinediones (TZDs) has a different effect on bone and fat physiology, pointing out a dual role of common factors present in periphery and bone marrow. Insulin signaling, lipid handling, oxidoreductase activity are nutrient-sensing pathways, which are affected by metabolic disturbances and play a critical role in the regulation of glucose metabolism and bone homeostasis. Here I will review our current findings on metabolic changes in BMAT phenotype and its effect on bone marrow microenvironment and stem cell properties in obesity. Also, I will present our recent data with different interventional approaches in animal models of obesity and their effects on BMAT and bone metabolism.

References

• Benova A, Ferencakova M, Bardova K, Funda J, Prochazka J, Spoutil F, Cajka T, Dzubanova M, Balcaen T, Kerckhofs G, Willekens W, van Lenthe GH, Alquicer G, Pecinova A, Mracek T, Horakova O, Rossmeisl M, Kopecky J, Tencerova M. Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones. Mol Metab. 2022 Nov;65:101598. doi: 10.1016/j.molmet.2022.101598. Epub 2022 Sep 11.
• Tencerova M, Ferencakova M, Kassem M. Bone marrow adipose tissue: Role in bone remodeling and energy metabolism. Best Pract Res Clin Endocrinol Metab. 2021 Jul;35(4):101545. doi: 10.1016/j.beem.2021.101545. Epub 2021 May 1.
• Benova A, Tencerova M. Obesity-Induced Changes in Bone Marrow Homeostasis. Front Endocrinol (Lausanne). 2020 May 12;11:294. doi: 10.3389/fendo.2020.00294. eCollection 2020.

Biography

Michaela Tencerova is a Principal Investigator at the Institute of Physiology (IPHYS) of the Czech Academy of Sciences in Prague. She has been the PI of the laboratory of Molecular Physiology of Bone since 2019. Her lab is focused on studying the role of bone marrow adiposity in the regulation of bone and whole-body metabolism. Through two abroad Postdoctoral trainings in Prof. Michael Czech`s lab (UMASS Medical School, USA) and Prof. Moustapha Kassem`s lab (SDU, Odense, Denmark) she moved her research interest from immunometabolism in obesity and diabetes to studying bone marrow adiposity and interactions between bone and stem cells metabolism in relation to metabolic diseases. She is a member of Scientific board of the Bone Marrow Adiposity Society (BMAS) and ECTS Basic science committee, ASBMR Women in Science committee. She is also a member of ECTS Academy.

IPHYS contact person: Michaela Tencerová, michaela.tencerova@fgu.cas.cz