Oddělení se zabývá výzkumem funkčních a farmakologických vlastností ionotropních receptorů (chemicky aktivovaných iontových kanálů), a to především glutamátových receptorů (iGluR) a iontových kanálů skupiny TRP (transient receptor potential). iGluR zprostředkovávají většinu excitační signalizace v centrálním nervovém systému, jsou zásadní pro vývoj a normální funkci mozku, ale jejich dysfunkce vede ke vzniku závažných neurologických a duševních onemocnění, včetně různých forem neurodegenerací. TRP se vyskytují v periferním i centrálním nervovém systému, kde zajišťují základní fyziologické a patofyziologické funkce, jakými jsou detekce a přenos bolestivých podnětů, či rozvoj chronických zánětlivých stavů.
Cílem studia je přispět k poznání vztahu mezi strukturou a funkcí ionotropních receptorů, identifikovat molekulární mechanizmy, jakými chemické látky a fyzikální vlivy modulují jejich aktivitu, a charakterizovat dopad lidských mutací na funkci receptorů, senzorických neuronů, synapsí a synaptických sítí. Získané výsledky prohlubují naše základní znalosti o mechanismu fungování ionotropních receptorů a dále slouží při vývoji nových alosterických modulátorů s terapeutickým potenciálem pro léčbu neurovývojových a neuropsychiatrických onemocnění.
Historie oddělení Vzpomínky na II. odd ČSAV
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Glutamate is the primary excitatory neurotransmitter in the central nervous system. NMDA receptors (NMDARs) are ionotropic glutamate receptors that detect glutamate in the context of ongoing circuit activity. NMDAR activation requires the binding of glutamate as an agonist and glycine as a co-agonist, together with sufficient membrane depolarization to relieve the voltage-dependent channel block by extracellular Mg2+. In addition, NMDAR function is tightly regulated by a number of endogenous modulators. Upon activation, the NMDAR forms a cation channel highly permeable to Ca2+, a second messenger that coordinates downstream signalling leading to activity-dependent changes in synaptic strength. NMDARs are therefore critical for the development of neural circuits and for their ability to process information.
Více
We investigate molecular mechanisms of nociception and thermosensation by focusing on thermosensitive transient receptor potential (TRP) ion channels. These channels are specifically expressed in primary nociceptive neurons and work in concert to detect potentially damaging stimuli and transduce them into pain signalling.
The goal of our research is to understand the physiological or pathophysiological significance of specific subclasses of TRP ion channels involved in the detection of noxious thermal, mechanical and chemical stimuli, through deciphering molecular and biophysical principles of their operational features.
We use electrophysiological and microfluorometric techniques, mainly patch-clamp recording at whole-cell and single-channel levels. For a more detailed understanding of TRP ion channel activation mechanisms we also use biochemistry and molecular biology combined with molecular modelling.
Více
Publikace
Lebedeva; M. - Kubištová; A. - Spišská; V. - Filipovská; E. - Pačesová; D. - Svobodová; I. - Kuchtiak; Viktor - Balík; Aleš - Bendová; Z.
The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice; a comparison with C57BL/6J and Adar2?/? mice strains
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Brain Research. 2024; 1826(1 March); 148739
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IF = 2.9
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doi
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Kysilov; Bohdan - Kuchtiak; Viktor - Hrčka Krausová; Barbora - Balík; Aleš - Kořínek; Miloslav - Fili; Klevinda - Dobrovolski; Mark - Abramová; Vera - Chodounská; Hana - Kudová; Eva - Božíková; Paulina - Černý; Jiří - Smejkalová; Tereza - Vyklický ml.; Ladislav
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Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
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Cellular and Molecular Life Sciences. 2024; 81(1); 36
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IF = 8.0
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doi
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Cheema; Marie Munawar - Kotrbová Macáková; Zuzana - Hrčka Krausová; Barbora - Adla; Santosh Kumar - Slavíková; Barbora - Chodounská; Hana - Kratochvíl; Miroslav - Vondrášek; Jiří - Sedlák; David - Balaštík; Martin - Kudová; Eva
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5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia
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Journal of Steroid Biochemistry and Molecular Biology. 2024; 239(May); 106464
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IF = 4.1
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doi
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Studtmann; C. - Ladislav; M. - Safari; M. - Khondaker; R. - Chen; Y. - Vaughan; G. A. - Topolski; M. A. - Tomović; E. - Balík; Aleš - Swanger; S. A.
Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties
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Journal of Neurophysiology. 2023; 130(6); 1492-1507
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IF = 2.5
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doi
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Kolcheva; Marharyta - Ladislav; M. - Netolický; J. - Kortus; Š. - Řeháková; K. - Hrčka Krausová; B. - Hemelíková; K. - Misiachna; A. - Kádková; A. - Klíma; Martin - Chalupská; Dominika - Horák; M.
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking; conductance; and pharmacological properties of NMDA receptors
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Neuropharmacology. 2023; 222(1 January)); 109297
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IF = 4.7
[ASEP]
[
doi
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Abramová; Vera - Leal Alvarado; Vanessa - Hill; M. - Smejkalová; Tereza - Malý; Michal - Valeš; Karel - Dittert; Ivan - Božíková; Paulina - Kysilov; Bohdan - Hrčka Krausová; Barbora - Vyklický; Vojtěch - Balík; Aleš - Fili; Klevinda - Kořínek; Miloslav - Chodounská; Hana - Kudová; Eva - Číž; D. - Martinovič; J. - Černý; Jiří - Bartůněk; Petr - Vyklický ml.; Ladislav
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Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior
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ACS Chemical Neuroscience. 2023; 14(10); 1870-1883
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IF = 5.0
[ASEP]
[
doi
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Zímová; Lucie - Ptáková; Alexandra - Mitro; Michal - Krůšek; Jan - Vlachová; Viktorie
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Activity dependent inhibition of TRPC1/4/5 channels by duloxetine involves voltage sensor-like domain
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Biomedicine & Pharmacotherapy. 2022; 152(August)); 113262
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IF = 7.5
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[
doi
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Zhang; L. - Simonsen; Ch. - Zímová; Lucie - Wang; K. - Moparthi; L. - Gaudet; R. - Ekoff; M. - Nilsson; G. - Hellmich; U. A. - Vlachová; Viktorie - Gourdon; P. - Zygmunt; P. M.
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
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Nature Communications. 2022; 13(1)); 7483
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IF = 16.6
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[
doi
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Štefková-Mazochová; K. - Danda; H. - Dehaen; W. - Jurásek; B. - Šíchová; K. - Pinterová-Leca; N. - Mazoch; V. - Hrčka Krausová; Barbora - Kysilov; Bohdan - Smejkalová; Tereza - Vyklický ml.; Ladislav - Kohout; M. - Hájková; K. - Svozil; Daniel - Horsley; R. R. - Kuchař; M. - Páleníček; T.
Pharmacokinetic; pharmacodynamic; and behavioural studies of deschloroketamine in Wistar rats
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British Journal of Pharmacology. 2022; 179(1); 65-83
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IF = 7.3
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[
doi
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Ptáková; Alexandra - Mitro; Michal - Zímová; Lucie - Vlachová; Viktorie
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Cellular context determines primary characteristics of human TRPC5 as a cold-activated channel
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Journal of Cellular Physiology. 2022; 237(9); 3614-3626
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IF = 5.6
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[
doi
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Moparthi; L. - Sinica; Viktor - Moparthi; V. K. - Kreir; M. - Vignane; T. - Filipovic; M. R. - Vlachová; Viktorie - Zygmunt; P. M.
The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
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Nature Communications. 2022; 13(1)); 6113
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IF = 16.6
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[
doi
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Kysilov; Bohdan - Hrčka Krausová; Barbora - Vyklický; Vojtěch - Smejkalová; Tereza - Kořínek; Miloslav - Horák; Martin - Chodounská; Hana - Kudová; Eva - Černý; Jiří - Vyklický ml.; Ladislav
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Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations
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British Journal of Pharmacology. 2022; 179(15); 3970-3990
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IF = 7.3
[ASEP]
[
doi
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Vyklický; Vojtěch - Stanley; Ch. - Habrian; Ch. - Isacoff; E. Y.
Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
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Nature Communications. 2021; 12(1)); 2694
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IF = 17.694
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doi
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Smejkalová; Tereza - Kořínek; Miloslav - Krůšek; Jan - Hrčka Krausová; Barbora - Candelas Serra; Miriam - Hajduković; Dragana - Kudová; Eva - Chodounská; Hana - Vyklický ml.; Ladislav
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Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms
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British Journal of Pharmacology. 2021; 178(19); 3888-3904
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IF = 9.473
[ASEP]
[
doi
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Sinica; Viktor - Vlachová; Viktorie
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Transient receptor potential ankyrin 1 channel: an evolutionarily tuned thermosensor
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Physiological Research. 2021; 70(3); 363-381
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IF = 2.139
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[
doi
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Nadezhdin; K. D. - Neuberger; A. - Trofimov; Yu. A. - Krylov; N. A. - Sinica; Viktor - Kupko; N. - Vlachová; Viktorie - Zakharian; E. - Efremov; R. G. - Sobolevsky; A. I.
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel
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Nature Structural & Molecular Biology. 2021; 28(7); 564-572
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IF = 18.361
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doi
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Míková; H. - Kuchtiak; Viktor - Svobodová; Irena - Spišská; V. - Pačesová; D. - Balík; Aleš - Bendová; Z.
Circadian Regulation of GluA2 mRNA Processing in the Rat Suprachiasmatic Nucleus and Other Brain Structures
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Molecular Neurobiology. 2021; 58(1); 439-449
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IF = 5.686
[ASEP]
[
doi
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Konečný; J. - Misiachna; Anna - Hrabinová; M. - Pulkrábková; L. - Benková; M. - Prchal; L. - Kučera; T. - Kobrlová; T. - Finger; V. - Kolcheva; Marharyta - Kortus; Štěpán - Jun; D. - Valko; M. - Horák; Martin - Soukup; O. - Korábečný; J.
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists
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Biomolecules. 2021; 11(1)); 3
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IF = 6.064
[ASEP]
[
doi
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Kolcheva; Marharyta - Kortus; Š. - Hrčka Krausová; B. - Baráčková; P. - Misiachna; A. - Danačíková; Šárka - Kaniaková; M. - Hemelíková; K. - Hotovec; M. - Řeháková; K. - Horák; M.
Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors
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Neuropharmacology. 2021; 189(15 May)); 108528
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IF = 5.273
[ASEP]
[
doi
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Kaniaková; Martina - Korábečný; J. - Holubová; Kristína - Kletečková; Lenka - Chvojková; Markéta - Hakenová; K. - Prchal; L. - Novák; M. - Doležal; R. - Hepnarová; V. - Svobodová; B. - Kučera; T. - Lichnerová; Katarina - Krausová; B. - Horák; Martin - Valeš; Karel - Soukup; O.
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
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Biochemical Pharmacology. 2021; 186(Apr)); 114460
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IF = 6.100
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doi
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Hubálková; Pavla - Ladislav; Marek - Vyklický; Vojtěch - Smejkalová; Tereza - Hrčka Krausová; Barbora - Kysilov; Bohdan - Krůšek; Jan - Naimová; Žaneta - Kořínek; Miloslav - Chodounská; Hana - Kudová; Eva - Černý; Jiří - Vyklický ml.; Ladislav
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Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity
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Journal of Neuroscience. 2021; 41(10); 2119-2134
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IF = 6.709
[ASEP]
[
doi
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Holubová; K. - Chvojková; M. - Hrčka Krausová; Barbora - Vyklický; Vojtěch - Kudová; Eva - Chodounská; Hana - Vyklický ml.; Ladislav - Valeš; Karel
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Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
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Biomolecules. 2021; 11(7)); 1026
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IF = 6.064
[ASEP]
[
doi
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Hirschfeldová; Kateřina - Černý; Jiří - Božíková; P. - Kuchtiak; Viktor - Rausch; T. - Beneš; V. - Španiel; F. - Greguš; D. - Horáček; J. - Vyklický ml.; Ladislav - Balík; Aleš
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Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia
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Journal of Personalized Medicine. 2021; 11(12)); 1250
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IF = 3.508
[ASEP]
[
doi
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Gorecki; L. - Misiachna; Anna - Damborský; J. - Doležal; R. - Korábečný; J. - Čejková; L. - Hakenová; K. - Chvojková; M. - Zdarová Karasová; J. - Prchal; L. - Novák; M. - Kolcheva; Marharyta - Kortus; Štěpán - Valeš; K. - Horák; Martin - Soukup; O.
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
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European Journal of Medicinal Chemistry. 2021; 219(5 July)); 113434
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IF = 7.088
[ASEP]
[
doi
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Bernal; L. - Sotelo-Hitschfeld; P. - König; Ch. - Sinica; Viktor - Wyatt; A. - Winter; Z. - Hein; A. - Touška; Filip - Reinhardt; S. - Tragl; A. - Kusuda; R. - Wartenberg; P. - Sclaroff; A. - Pfeifer; J. D. - Ectors; F. - Dahl; A. - Freichel; M. - Vlachová; Viktorie - Brauchi; S. - Roza; C. - Boehm; U. - Clapham; D. E. - Lennerz; J. K. - Zimmermann; K.
Odontoblast TRPC5 channels signal cold pain in teeth
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Science Advances. 2021; 7(13)); eabf5567
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IF = 14.980
[ASEP]
[
doi
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Baluchová; Simona - Brycht; M. - Taylor; Andrew - Mortet; Vincent - Krůšek; Jan - Dittert; Ivan - Sedláková; Silvia - Klimša; Ladislav - Kopeček; Jaromír - Schwarzová-Pecková; K.
Enhancing electroanalytical performance of porous boron-doped diamond electrodes by increasing thickness for dopamine detection
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Analytica Chimica Acta. 2021; 1182(Oct); 1-16); 338949
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IF = 6.911
[ASEP]
[
doi
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Zímová; Lucie - Barvíková; Kristýna - Máčiková; Lucie - Vyklická; Lenka - Sinica; Viktor - Barvík; I. - Vlachová; Viktorie
.
Proximal C-Terminus Serves as a Signaling Hub for TRPA1 Channel Regulation via Its Interacting Molecules and Supramolecular Complexes
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Frontiers in physiology. 2020; 11(Mar 12)); 189
.
IF = 4.566
[ASEP]
[
doi
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Sinica; Viktor - Zímová; Lucie - Barvíková; Kristýna - Máčiková; Lucie - Barvík; I. - Vlachová; Viktorie
.
Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage
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Cells. 2020; 9(1)); 57
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IF = 6.600
[ASEP]
[
doi
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Park; DH. - Park; S. - Song; JM. - Kang; M. - Lee; S. - Horák; Martin - Suh; Y. H.
N-linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1
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FASEB Journal. 2020; 34(11); 14977-14996
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IF = 5.191
[ASEP]
[
doi
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Kořínek; Miloslav - González-González; I. M. - Smejkalová; Tereza - Hajduković; Dragana - Skřenková; Kristýna - Krůšek; Jan - Horák; Martin - Vyklický ml.; Ladislav
.
Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
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Scientific Reports. 2020; 10(1)); 12651
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IF = 4.379
[ASEP]
[
doi
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Klempíř; O. - Krupička; R. - Krůšek; Jan - Dittert; Ivan - Petráková; V. - Petrák; V. - Taylor; Andrew
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Application of Spike Sorting Algorithm to Neuronal Signals Originated from Boron Doped Diamond Micro-Electrode Arrays
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Physiological Research. 2020; 69(3); 529-536
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IF = 1.881
[ASEP]
[
doi
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Hrčka Krausová; Barbora - Kysilov; Bohdan - Černý; Jiří - Vyklický; Vojtěch - Smejkalová; Tereza - Ladislav; Marek - Balík; Aleš - Kořínek; Miloslav - Chodounská; Hana - Kudová; Eva - Vyklický ml.; Ladislav
.
Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor
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Journal of Neuroscience. 2020; 40(31); 5922-5936
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IF = 6.167
[ASEP]
[
doi
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Barvíková; Kristýna - Barvík; I. - Sinica; Viktor - Zímová; Lucie - Vlachová; Viktorie
.
Phospho-Mimetic Mutation at Ser602 Inactivates Human TRPA1 Channel
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International Journal of Molecular Sciences. 2020; 21(21)); 7995
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IF = 5.923
[ASEP]
[
doi
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Skřenková; Kristýna - Hemelíková; Katarína - Kolcheva; Marharyta - Kortus; S. - Kaniaková; Martina - Krausová; Barbora - Horák; Martin
.
Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
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Scientific Reports. 2019; 9(Aug 23)); 12303
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IF = 3.998
[ASEP]
[
doi
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Máčiková; Lucie - Vyklická; Lenka - Barvík; I. - Sobolevsky; A. I. - Vlachová; Viktorie
.
Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel
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International Journal of Molecular Sciences. 2019; 20(16)); 3990
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IF = 4.556
[ASEP]
[
doi
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Máčiková; Lucie - Sinica; Viktor - Kádková; Anna - Villette; S. - Ciaccafava; A. - Faherty; J. - Lecomte; S. - Alves; I. D. - Vlachová; Viktorie
.
Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials
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FEBS Journal. 2019; 286(18); 3664-3683
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IF = 4.392
[ASEP]
[
doi
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Krůšek, Jan - Dittert, Ivan - Smejkalová, Tereza - Kořínek, Miloslav - Gottfriedová, Kristýna - Freislebenová, Hana - Neuhöferová, Eva - Klimša, Ladislav - Sedláková, Silvia - Taylor, Andrew - Mortet, Vincent - Petrák, V. - Benson, Veronika - Petráková, V.
Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons
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Physica Status Solidi B-Basic Solid State Physics 2019, 256(3), 1800424
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IF = 1.481
[ASEP]
[
doi
]
Kaniaková; Martina - Nepovímová; E. - Kletečková; L. - Skřenková; K. - Holubová; K. - Chrienová; Z. - Hepnarová; V. - Kučera; T. - Kobrlová; T. - Valeš; K. - Korábečný; J. - Soukup; O. - Horák; Martin
.
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
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Current Alzheimer Research. 2019; 16(9); 821-833
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IF = 3.047
[ASEP]
[
doi
]
Chiu; A. M. - Wang; J. - Fiske; M. P. - Hubálková; Pavla - Barse; L. - Gray; J. A. - Sanz-Clemente; A.
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
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Cell Reports. 2019; 28(2); 332-341
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IF = 8.109
[ASEP]
[
doi
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Chiu; A. M. - Barse; L. - Hubálková; Pavla - Sanz-Clemente; A.
An Antibody Feeding Approach to Study Glutamate Receptor Trafficking in Dissociated Primary Hippocampal Cultures
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Jove-Journal of Visualized Experiments. 2019; 150(Aug)); e59982
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IF = 1.163
[ASEP]
[
doi
]
Hemelíková; Katarína - Kolcheva; Marharyta - Skřenková; Kristýna - Kaniaková; Martina - Horák; Martin
.
Lectins modulate the functional properties of GluN1/GluN3-containing NMDA receptors
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Neuropharmacology. 2019; 157(Oct)); UNSP 107671
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IF = 4.431
[ASEP]
[
doi
]
Černý; Jiří - Božíková; P. - Balík; Aleš - Marques; S. M. - Vyklický ml.; Ladislav
.
NMDA Receptor Opening and Closing-Transitions of a Molecular Machine Revealed by Molecular Dynamics
.
Biomolecules. 2019; 9(10)); 546
.
IF = 4.082
[ASEP]
[
doi
]
Zímová, Lucie - Sinica, Viktor - Kádková, Anna - Vyklická, Lenka - Zíma, Vlastimil - Barvík, I. - Vlachová, Viktorie
.
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
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Science Signaling 2018, roč. 11, 514, článku eaan8621
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IF = 6.481
[ASEP]
[
doi
]
Vyklický, Vojtěch - Krausová, Barbora - Černý, Jiří - Ladislav, Marek - Smejkalová, Tereza - Kysilov, Bohdan - Kořínek, Miloslav - Danačíková, Šárka - Horák, Martin - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav
.
Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
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Frontiers in Molecular Neuroscience 2018, roč. 11, Apr 6, článku 110
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IF = 3.720
[ASEP]
[
doi
]
Touška, Filip - Turnquist, B. - Vlachová, Viktorie - Reeh, P. W. - Leffler, A. - Zimmermann, K.
Heat-resistant action potentials require TTX-resistant sodium channels Na(V)1.8 and Na(V)1.9
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Journal of General Physiology 2018, roč. 150, 8, p. 1125-1144
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IF = 4.258
[ASEP]
[
doi
]
Skřenková, Kristýna - Lee, S. - Lichnerová, Katarina - Kaniaková, M. - Hansíková, H. - Zápotocký, Martin - Suh, Y. H. - Horák, Martin
.
N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors
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Frontiers in Molecular Neuroscience 2018, roč. 11, Jun 4, článku 188
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IF = 3.720
[ASEP]
[
doi
]
Průcha, J. - Krůšek, Jan - Dittert, Ivan - Sinica, Viktor - Kádková, Anna - Vlachová, Viktorie
.
Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons
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Journal of Cellular and Molecular Medicine 2018, roč. 22, 2, p. 1355-1362
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IF = 4.658
[ASEP]
[
doi
]
Ladislav, Marek - Černý, Jiří - Krůšek, Jan - Horák, Martin - Balík, Aleš - Vyklický ml., Ladislav
.
The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate
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Frontiers in Molecular Neuroscience 2018, roč. 11, Apr 6, článku 113
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IF = 3.720
[ASEP]
[
doi
]
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Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif
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The pharmacology of tacrine at N-methyl-D-aspartate receptors
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Characterization of pollen-expressed bZIP protein interactions and the role of ATbZIP18 in the male gametophyte
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[
doi
]
Kaniaková, Martina - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin
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Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors
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Journal of Neurochemistry, 2012, Vol. 123, 3, p. 385-395
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IF = 3.973
[ASEP]
[
doi
]
Kaniaková, Martina - Krausová, Barbora - Vyklický, Vojtěch - Kořínek, Miloslav - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin
.
Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors
.
Journal of Biological Chemistry, 2012, Vol. 287, 31, p. 26423-26434
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IF = 4.651
[ASEP]
[
doi
]
Hřebabecký, Hubert - Dejmek, Milan - Dračínský, Martin - Šála, Michal - Leyssen, P. - Neyts, J. - Kaniaková, Martina - Krůšek, Jan - Nencka, Radim
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Synthesis of novel azanorbornylpurine derivatives
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Tetrahedron, 2012, Vol. 68, 4, p. 1286-1298
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IF = 2.803
[ASEP]
[
doi
]
Borovská, Jiřina - Vyklický, Vojtěch - Šťastná, Eva - Kapras, Vojtěch - Slavíková, Barbora - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav
.
Access of inhibitory neurosteroids to the NMDA receptor
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British Journal of Pharmacology, 2012, Vol. 166, 3, p. 1069-1083
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IF = 5.067
[ASEP]
[
doi
]
Penn, A.C. - Balík, Aleš - Wozny, Ch. - Cais, O. - Greger, I. H.
Activity-Mediated AMPA Receptor Remodeling, Driven by Alternative Splicing in the Ligand-Binding Domain
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Neuron, 2012, Vol. 76, 3, p. 503-510
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IF = 15.766
[ASEP]
[
doi
]
Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Borovská, Jiřina - Vyklický ml., Ladislav
.
Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity
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Collection of Czechoslovak Chemical Communications, 2011, Vol. 76, 9, p. 1141-1161
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IF = 1.283
[ASEP]
[
doi
]
Volkov, E. M. - Nurullin, L. F. - Volkov, M. E. - Nikolsky, E. E. - Vyskočil, František
.
Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles
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Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 2011, Vol. 158, 4, p. 520-524
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IF = 2.235
[ASEP]
[
doi
]
Vidrna, Lukáš - Černý, Ivan - Pouzar, Vladimír - Borovská, Jiřina - Vyklický, Vojtěch - Vyklický ml., Ladislav - Chodounská, Hana
.
Azido analogs of neuroactive steroids
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Steroids, 2011, Vol. 76, 10/11, p. 1043-1050
.
IF = 2.829
[ASEP]
[
doi
]
Touška, Filip - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie
.
A “Cute” Desensitization of TRPV1
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Current Pharmaceutical Biotechnology, 2011, Vol. 12, 1, p. 122-129
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IF = 2.805
[ASEP]
Soukup, O. - Krůšek, Jan - Kaniaková, Martina - Kumar, U. K. - Oz, M. - Jun, D. - Fusek, J. - Kuča, K. - Tobin, G.
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
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Physiological Research, 2011, Vol. 60, 4, p. 679-686
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IF = 1.555
[ASEP]
Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie
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The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
.
Biochemical Journal, 2011, Vol. 433, 1, p. 197-204
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IF = 4.897
[ASEP]
[
doi
]
Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristina - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., La
.
Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate
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Neuropharmacology, 2011, Vol. 61, 1-2, p. 61-68
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IF = 4.814
[ASEP]
Malomouzh, A. I. - Arkhipova, S. S. - Nikolsky, E. E. - Vyskočil, František
.
Immunocytochemical demonstration of M1 muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates
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Physiological Research, 2011, Vol. 60, 1, p. 185-188
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IF = 1.555
[ASEP]
Kořínek, Miloslav - Kapras, Vojtěch - Vyklický, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Valeš, Karel - Stuchlík, Aleš - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav
.
Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects
.
Steroids, 2011, Vol. 76, 13, p. 1409-1418
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IF = 2.829
[ASEP]
[
doi
]
Kaniaková, Martina - Lindovský, Jiří - Krůšek, Jan - Adámek, S. - Vyskočil, František
.
Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors
.
European Journal of Pharmacology, 2011, Vol. 658, 2-3, p. 108-113
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IF = 2.516
[ASEP]
[
doi
]
Adámek, S. - Vyskočil, František
.
Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain
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Brain Research, 2011, Vol. 1370, -, p. 215-219
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IF = 2.728
[ASEP]
[
doi
]
Osičková, Adriana - Mašín, Jiří - Fayolle, C. - Krůšek, Jan - Basler, Marek - Pospíšilová, Eva - Leclerc, C. - Osička, Radim - Šebo, Peter
.
Adenylate cyclase toxin translocates across target cell membrane without forming a pore
.
Molecular Microbiology, 2010, Vol. 75, 6, p. 1550-1562
.
IF = 4.819
[ASEP]
[
doi
]
Kořínek, Miroslav - Sedláček, Miloslav - Cais, Ondřej - Dittert, Ivan - Vyklický ml., Ladislav
.
Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents
.
Neuroscience, 2010, Vol. 165, 3, p. 736-748
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IF = 3.215
[ASEP]
[
doi
]
Boukalová, Štěpána - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie
.
Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels
.
Journal of Biological Chemistry, 2010, Vol. 285, 53, p. 41455-41462
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IF = 5.328
[ASEP]
[
doi
]
Adámek, S. - Shakirzyanova, V. - Malomouzh, A. I. - Naumenko, N. V. - Vyskočil, František
.
Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction
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Physiological Research, 2010, Vol. 59, 5, p. 803-810
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IF = 1.646
[ASEP]
Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Kapras, Vojtěch - Borovská, Jiřina - Cais, Ondřej - Vyklický ml., Ladislav
.
Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons
.
Steroids, 2009, Vol. 74, 2, p. 256-263
.
IF = 2.905
[ASEP]
[
doi
]
Vyskočil, František - Malomouzh, A. I. - Nikolsky, E. E.
Non-quantal acetylcholine release at the neuromuscular junction
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Physiological Research, 2009, Vol. 58, 6, p. 763-784
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IF = 1.430
[ASEP]
Tyapkina, O. - Volkov, E. - Nurullin, L. - Shenkman, B. - Kozlovskaya, I. - Nikolsky, E. - Vyskočil, František
.
Resting membrane potential and Na+,K+-ATPase of rat fast and slow muscles during modeling of hypogravity
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Physiological Research, 2009, Vol. 58, 4, p. 599-603
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IF = 1.430
[ASEP]
Shaihutdinova, A.R. - Nikolsky, E. E. - Vyskočil, František - Skorinkin, A.I.
Mechanisms of the inhibition of endplate acetylcholine receptors by antiseptic chlorhexidine (experiments and models)
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Naunyn-Schmiedeberg's Archiv of Pharmacology, 2009, Vol. 380, 6, p. 551-560
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IF = 2.631
[ASEP]
[
doi
]
Petrovič, Miloš - Sedláček, Miloslav - Cais, Ondřej - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav
.
Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent
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Neuroscience, 2009, Vol. 160, 3, p. 616-628
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IF = 3.292
[ASEP]
[
doi
]
Petrov, K. - Kovyazina, I. - Zobov, V. - Bukharaeva, E. - Nikolsky, E. E. - Vyskočil, František
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Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum Pontus
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Physiological Research, 2009, Vol. 58, 1, p. 149-153
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IF = 1.430
[ASEP]
Brantová, O. - Asfaw, B. - Sládková, J. - Poupětová, H. - Živný, J. - Magner, M. - Krůšek, Jan - Veselá, K. - Hansíková, H. - Ledvinová, J. - Tesařová, M. - Zeman, J.
Ultrastructural and functional abnormalities of mitochondria in cultivated fibroblasts from α -mannosidosis patiens
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Biologia, 2009, Vol. 64, 2, p. 394-401
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IF = 0.617
[ASEP]
[
doi
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Benedikt, Jan - Samad, Abdul - Ettrich, Rüdiger - Teisinger, Jan - Vlachová, Viktorie
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Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel
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Biochimica Et Biophysica Acta-Molecular Cell Research, 2009, Vol. 1793, 7, p. 1279-1288
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IF = 4.374
[ASEP]
[
doi
]
Vyklický st., Ladislav - Nováková-Toušová, Karolina - Benedikt, Jan - Samad, Abdul - Touška, Filip - Vlachová, Viktorie
.
Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
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Physiological Research, 2008, Vol. 57, Suppl.3, S59-S68
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IF = 1.653
[ASEP]
Skorinkin, A.I. - Shaihutdinova, A.R. - Vyskočil, František
.
Model of concentration changes across the synaptic cleft during a single quantum release
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General Physiology and Biophysics, 2008, Vol. 27, 1, p. 19-24
.
IF = 0.697
[ASEP]
Sedláček, Miloslav - Kořínek, Miroslav - Petrovič, Miloš - Cais, Ondřej - Adamusová, Eva - Chodounská, Hana - Vyklický ml., Ladislav
.
Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission
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Physiological Research, 2008, Vol. 57, Suppl.3, S49-S57
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IF = 1.653
[ASEP]
Petrovič, Miloš - Valeš, Karel - Putnikovič, B. - Djulejič, V. - Mitrovič, D. M.
Ryanodine receptors, voltage-gated calcium channels and their relationship with protein kinase A in the myocardium
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Physiological Research, 2008, Vol. 57, 2, p. 141-149
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IF = 1.653
[ASEP]
Ostašov, Pavel - Krůšek, Jan - Durchánková, Dana - Svoboda, Petr - Novotný, Jiří
.
Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization
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Cell Biochemistry and Function, 2008, Vol. 26, 2, p. 264-274
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IF = 1.333
[ASEP]
[
doi
]
Lindovský, Jiří - Kaniaková, Martina - Svobodová, Lucie - Vyskočil, František - Krůšek, Jan
.
Role of negatively charged amino acids in beta4 F-loop in activation and desensitization of alfa3beta4 rat neuronal nicotinic receptors
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Biochimica Et Biophysica Acta-Biomembranes, 2008, Vol. 1778, 4, p. 864-871
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IF = 4.180
[ASEP]
Gilmanov, I.R. - Samigullin, D. V. - Vyskočil, František - Nikolsky, E. E. - Bukharaeva, E. A.
Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers
.
Journal of Computational Neuroscience, 2008, Vol. 25, 2, p. 296-307
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IF = 2.750
[ASEP]
[
doi
]
Ellederová, Zdeňka - Cais, Ondřej - Šušor, Andrej - Uhlířová, Kateřina - Kovářová, Hana - Jelínková, Lucie - Tomek, W. - Kubelka, Michal
.
ERK 1/2 kinase metabolic pathway is responsible for phosphorylation of translation initiation factor eIF4E during in vitro maturation of pig oocytes
.
Molecular Reproduction and Development, 2008, Vol. 75, 2, p. 309-317
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IF = 2.287
[ASEP]
Cais, Ondřej - Sedláček, Miloslav - Horák, Jaroslav - Dittert, Ivan - Vyklický ml., Ladislav
.
Temperature dependence of NR1/NR2B NMDA receptor channels
.
Neuroscience, 2008, Vol. 151, 2, p. 428-438
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IF = 3.556
[ASEP]
[
doi
]
Volkov, E. M. - Nurullin, L. F. - Nikolsky, E. - Vyskočil, František
.
Miniature excitatory synaptic ion currents in the earthworm Lumbricus terrestris body wall muscles
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Physiological Research, 2007, Vol. 56, 5, p. 655-658
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IF = 1.505
[ASEP]
Sušánková, Klára - Ettrich, Rüdiger - Vyklický st., Ladislav - Teisinger, Jan - Vlachová, Viktorie
.
Contribution of the putative inner-pore region to the gating of the Transient Receptor Potential Vanilloid Subtype 1 Channel (TRPV1)
.
Journal of Neuroscience, 2007, Vol. 27, 28, p. 7578-7585
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IF = 7.490
[ASEP]
Sedláček, Miloslav - Horák, Martin - Vyklický ml., Ladislav
.
Morphology and physiology of lamina I neurons of the caudal part of the trigeminal nucleus
.
Neuroscience, 2007, Vol. 147, 2, p. 325-333
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IF = 3.352
[ASEP]
Nováková-Toušová, Karolina - Vyklický st., Ladislav - Sušánková, Klára - Benedikt, Jan - Samad, Abdul - Teisinger, Jan - Vlachová, Viktorie
.
Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization
.
Neuroscience, 2007, Vol. 149, 1, p. 144-154
.
IF = 3.352
[ASEP]
Malomouzh, A. I. - Mukhtarov, M. R. - Nikolsky, E. E. - Vyskočil, František
.
Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism
.
Journal of Neurochemistry, 2007, Vol. 102, 6, p. 2110-2117
.
IF = 4.451
[ASEP]
Gryčová, Lenka - Lánský, Zdeněk - Friedlová, Eliška - Vlachová, Viktorie - Kubala, M. - Obšilová, Veronika - Obšil, Tomáš - Teisinger, Jan
.
ATP binding site on the C-terminus of the vanilloid
.
Archives of Biochemistry and Biophysics, 2007, Vol. 465, 2, p. 389-398
.
IF = 2.578
[ASEP]
Fišer, Radovan - Mašín, Jiří - Basler, Marek - Krůšek, Jan - Špuláková, V. - Konopásek, Ivo - Šebo, Peter
.
Third Acivity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin
.
Journal of Biological Chemistry, 2007, Vol. 282, 5, p. 2808-2820
.
IF = 5.581
[ASEP]
Benedikt, Jan - Teisinger, Jan - Vyklický st., Ladislav - Vlachová, Viktorie
.
Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate
.
Journal of Neurochemistry, 2007, Vol. 100, 1, p. 211-224
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IF = 4.451
[ASEP]
Podzim 2019