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Laboratory of Biomaterials and Tissue Engineering

Laboratory of Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.



Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More


Vagnerová; Karla - Gazárková; T. - Vodička; Martin - Ergang; Peter - Klusoňová; Petra - Hudcovic; Tomáš - Šrůtková; Dagmar - Hermanová; Petra - Nováková; L. - Pácha; Jiří . Microbiota modulates the steroid response to acute immune stress in male mice . Frontiers in Immunology. 2024; 15(Feb 1); 1330094 . IF = 7.3 [ASEP] [ doi ]
Trávníčková; Martina - Filová; Elena - Slepička; P. - Kasálková-Slepičková; N. - Kocourek; Tomáš - Žaloudková; Margit - Suchý; Tomáš - Bačáková; Lucie . Titanium-Doped Diamond-like Carbon Layers as a Promising Coating for Joint Replacements Supporting Osteogenic Differentiation of Mesenchymal Stem Cells . International Journal of Molecular Sciences. 2024; 25(5); 2837 . IF = 5.6 [ASEP] [ doi ]
Šuca; H. - Čoma; M. - Tomšů; Júlia - Sabová; J. - Zajíček; R. - Brož; Antonín - Doubková; Martina - Novotný; T. - Bačáková; Lucie - Jenčová; V. - Kuželová Košťáková; E. - Lukačín; Š. - Rejman; Dominik - Gál; P. Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review . Journal of Surgical Research. 2024; 296(April); 383-403 . IF = 2.2 [ASEP] [ doi ]
Jágr; M. - Hofinger-Horvath; B. - Ergang; Peter - Čepková Hlásná; P. - Schönlechner; R. - Pichler; E. Ch. - DAmico; S. - Grausgruber; H. - Vagnerová; Karla - Dvořáček; V. Comprehensive study of the effect of oat grain germination on the content of avenanthramides . Food Chemistry. 2024; 437(Part 1 30 March); 137807 . IF = 8.8 [ASEP] [ doi ]
Blanquer; Andreu - Kuželová Košťáková; E. - Filová; Elena - Lisnenko; M. - Brož; Antonín - Müllerová; J. - Novotný; V. - Havlíčková; K. - Jakubková; Š. - Hauzerová; Š. - Heczková; B. - Procházková; R. - Bačáková; Lucie - Jenčová; V. A novel bifunctional multilayered nanofibrous membrane combining polycaprolactone and poly (vinyl alcohol) enriched with platelet lysate for skin wound healing . Nanoscale. 2024; 16(4); 1924-1941 . IF = 6.7 [ASEP] [ doi ]

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Doc. MUDr. Lucie Bačáková, CSc.
Head of the Laboratory

Mgr. Elena Filová, Ph.D.
Deputy Head of the Laboratory


Ing. Irena Vacková, CSc.

Věra Lisá, prom. biol.
RNDr. Jana Musílková, CSc.
RNDr. Lubica Staňková (nee. Grausová), Ph.D.
RNDr. Lucie Svobodová, Ph.D.

Mgr. Antonín Brož, Ph.D.

MUDr. Jaroslav Chlupáč, Ph.D.
Postdoctoral Researcher
Mgr. Ivana Němčáková (nee. Kopová), Ph.D.
Postdoctoral Researcher (maternity leave)
Ing. Jana Zárubová (nee. Havlíková), Ph.D.
Postdoctoral Researcher
MUDr. Martina Trávníčková, Ph.D.
Postdoctoral Researcher (maternity leave)
Mgr. Júlia Tomšů, Ph.D.
Postdoctoral Researcher (maternity leave)
Mgr. Martina Doubková
PhD Student
Mgr. Antonín Sedlář
PhD Student

Mgr. Šimon Pražák
PhD Student

  MSc. Marina Malić
PhD Student
  MSc. Yu-Chieh Wu
PhD Student
Mgr. Jarmila Knitlová
PhD Student
Ivana Zajanová
  Bc. Terézia Futóová
MSc. student
  Bc. Andrea Hejdová
MSc. student
  Bc. Adriena Přitasilová
MSc. student