INSTITUTE OF PHYSIOLOGY CAS

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

Cardiovascular effects of new antidiabetics – gliflozins in model of experimental hypertension and chronic heart failure
Central and peripheral mechanisms of blood pressure regulation
Role of sympathetic and parasympathetic nervous system in cardiovascular diseases
Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).

Projects

Obesity, type 2 diabetes and neurodegeneration crosstalk: New therapeutic potential of prolactin-releasing peptide analogs

Role of Brain Angiotensin II, Nitric Oxide and Reactive Oxygen Species in Blood Pressure Control: The Importance in Contrasting Forms of Hypertension

Complex analysis of protective actions of empagliflozin on metabolic parameters and cardiorenal damage in experimental non-diabetic Hypertension

Central and peripheral modulation of vascular tone and sodium excretion: the role of brain and kidney in pathophysiology of hypertension

Stress-induced modulation of baroreflex sensitivity in spontaneously hypertensive rats: the role of renin-angiotensin system and glucocorticoids

Bilateral Mobility Project with Polish Academy of Sciences

Our latest publications

Josef Zicha was granted by the Jan Evangelista Purkinje Medal for the achievements in biomedical sciences (2020)

Jaroslav Kuneš was granted by the Gregor Johann Mendel Medal for the achievements in natural sciences (2018)

15th International Conference on Endothelin organized in Prague in 2017

IOCB Prague and Institute of Physiology have signed license agreement with Novo Nordisk

Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes. More

Successfull presentation at 26th International Meeting of International Society of Hypertension in Seoul

Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences. More

Michal Behuliak was granted by the director of the Institute of Physiology the Young Investigator award for authors under 35 years

Michal Behuliak was granted by the general manager of Servier the Young Investigator award

Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic. More

Otto Wichterle prize was granted to Mgr. Michal Behuliak

Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016. More

Joint laboratory of IPHYS and IOCHB

Publications

Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance . Nutrients. 2023; 15(2)); 280 . IF = 6.706 [ASEP] [ doi ]

Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula . Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157 . IF = 7.419 [ASEP] [ doi ]

Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension . Journal of Hypertension. 2023; 41(1); 99-114 . IF = 4.776 [ASEP] [ doi ]

Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana . Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension . Physiological Research. 2022; 71(6); 763-770 . IF = 2.139 [ASEP] [ doi ]

Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.528 [ASEP] [ doi ]

	RNDr. Ivana Vaněčková, DSc. Head of the Laboratory
	MUDr. Josef Zicha, DrSc. Deputy Head of the Laboratory
	RNDr. Jaroslav Kuneš, DrSc. Senior Researcher
	MUDr. Hana Rauchová, CSc. Senior Researcher
	RNDr. Milada Dobiášová, DrSc. Senior Researcher
	Mgr. Michal Behuliak, Ph.D. Senior Researcher
	Ing. Michaela Kadlecová, Ph.D. Research Assistant
	Mgr. Silvie Hojná, Ph.D. Research Assistant
	RNDr. Lenka Řezáčová, Ph.D. Research Assistant
	Bc. Martina Sabolová Pregradual student
	Alena Charvátová Technician
	Zdeňka Kopecká Technician

Laboratory of Experimental Hypertension