Intranet Areál web

Lecture "Lipid metabolism during heart failure"

RNDr. Ondřej Kuda, Ph.D., Laboratory of Metabolism of Bioactive Lipids, IPHYS

Heart failure (HF) is a multifaceted cardiovascular disorder marked by compromised cardiac function and metabolic disturbances. Metabolomics and lipidomics approaches have emerged as valuable tools to investigate the intricate metabolic changes associated with HF and its related complications, such as cachexia. Among the various tissues involved in HF pathophysiology, epicardial adipose tissue (EAT) has garnered attention due to its proximity to the heart and its potential role in cardiac remodeling and adaptations. By employing metabolite profiling techniques, we have been able to identify and quantify a wide array of metabolites in EAT, shedding light on altered metabolic pathways and lipid composition in HF. This study has revealed perturbations in energy metabolism and lipid signaling, providing insights into the underlying mechanisms contributing to HF progression and cachexia development. The comprehensive analysis of metabolites in EAT holds promise for uncovering potential biomarkers, therapeutic targets, and personalized treatment strategies for HF patients, ultimately aiming to improve clinical management and outcomes in this challenging cardiovascular condition.


Ondrej Kuda is a Principal Investigator at the Institute of Physiology (IPHYS) of the Czech Academy of Sciences in Prague. He has been the PI of the laboratory of Metabolism of bioactive lipids since 2019. His lab is focused on studying the role of lipid mediators, oxylipins, and metabolic pathways in metabolic diseases.


IPHYS contact person: Ondřej Kuda,