Cutting-edge science for health

Laboratory of Metabolism of Bioactive Lipids

Laboratory of Metabolism of Bioactive Lipids Metabolism of bioactive lipids

The Laboratory focuses on the analysis of lipid mediators (eicosanoids, docosanoids, endocannabinoids) using the UPLC-MS/MS method, in particular to identify the source of production of various mediators and their effect on metabolism and immune cells (i.e. adipocytes vs. macrophages). Currently, the lab is exploring new anti-diabetic lipids, fatty acid esters of hydroxy fatty acids and lipid-related metabolic pathways using stable isotopes and LIMeX platform.

We are always interested to hear from prospective (MSc, PhD or postdoc) candidates. Please submit a short personal statement detailing your research interests and qualifications, and a CV by email, RE: "metabolomics".

FluxAtlas FluxAtlas - interactive metabolomics, lipidomics and fluxomics atlas of mouse tissues during oral glucose tolerance test (OGTT).

MetaboAtlas21 MetaboAtlas21 - a comprehensive atlas of the mouse metabolome and lipidome.


Metabolomics, lipidomics and fluxomics

FluxAtlas - interactive metabolomics, lipidomics and fluxomics atlas of mouse tissues during oral glucose tolerance test (OGTT) Methodological highlighs from publications using small molecule omics techniques. More

Open science

Our lab participates in OPEN SCIENCE initiative and hosts high school students with their project in metabolomics. More

Branched fatty acid esters of hydroxy fatty acids (FAHFA)

White adipose tissue (WAT) is a complex endocrine organ and its low-grade inflammation in obesity contributes to the development of metabolic disorders. In 2014, a class of WAT-born lipid mediators - fatty acid esters of hydroxy fatty acids (FAHFA) was discovered. FAHFAs are endogenous lipids with anti-inflammatory and anti-diabetic properties, including the enhancement of glucose tolerance, and insulin and glucagon-like peptide 1 (GLP-1) secretion while reducing inflammatory responses [1-5]. More

Chemoinformatics resources

We run local instances of several services focused on Metabolomics, Lipidomics, Statistical analysis and Chemometrics. As the hardware resources are limited, these tools are available only within campus LAN. More

Omega-3 polyunsaturated fatty acids

Naturally occurring long-chain omega-3 PUFA, namely eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) exert multiple biological effects... More



van der Hoek; M. D. - Nieuwenhuizen; A. G. - Kuda; Ondřej - Bos; P. - Palůchová; Veronika - Verschuren; L. - van den Hoek; A. M. - Kleemann; R. - Veeger; N. J. G. M. - van der Leij; F. R. - Keijer; J. Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females; but not in males . FASEB Journal. 2020; 34(9); 11658-11671 . IF = 4.966 [ASEP] [ doi ]
Rossmeisl; Martin - Pavlišová; Jana - Bardová; Kristina - Kalendová; Veronika - Burešová; Jana - Kuda; Ondřej - Kroupová; Petra - Staňková; B. - Tvrzická; E. - Fišerová; E. - Horáková; Olga - Kopecký; Jan . Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice . Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2020; 1865(8)); 158732 . IF = 4.519 [ASEP] [ doi ]
Pomar; C. A. - Kuda; Ondřej - Kopecký; Jan - Rombaldová; Martina - Castro; H. - Picó; C. - Sánchez; J. - Palou; A. Maternal diet; rather than obesity itself; has a main influence on milk triacylglycerol profile in dietary obese rats . Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2020; 1865(2)); 158556 . IF = 4.519 [ASEP] [ doi ]
Palůchová; Veronika - Vik; A. - Čajka; Tomáš - Březinová; Marie - Brejchová; Kristýna - Bugajev; Viktor - Dráberová; Lubica - Dráber; Peter - Burešová; Jana - Kroupová; Petra - Bardová; Kristina - Rossmeisl; Martin - Kopecký; Jan - Hansen; T. V. - Kuda; Ondřej . Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice . Molecular Nutrition & Food Research. 2020; 64(11)); 1901238 . IF = 5.309 [ASEP] [ doi ]
Palůchová; Veronika - Oseeva; Marina - Březinová; Marie - Čajka; Tomáš - Bardová; Kristina - Adamcová; Kateřina - Žáček; Petr - Brejchová; Kristýna - Balas; L. - Chodounská; Hana - Kudová; Eva - Schreiber; R. - Zechner; R. - Durand; T. - Rossmeisl; Martin - Abumrad; N. A. - Kopecký; Jan - Kuda; Ondřej . Lipokine 5-PAHSA is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for de novo Lipogenesis in Mice . Diabetes. 2020; 69(3); 300-312 . IF = 7.720 [ASEP] [ doi ]

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Ondrej Kuda, Ph.D.
Head of the Laboratory
Kristyna Brejchova, Ph.D.
Magno Alves Lopes, Ph.D.
Postdoctoral Fellow
Ing. Veronika Paluchova
Postgradual Student
Mgr. Martin Riečan
Postgradual Student
Felipe Martínez Ramírez, MSc.
postgradual student

Mgr. Marie Březinová
Postgradual Student (maternity leave)
Mgr. Martina Rombaldová, Ph.D.
(maternity leave)
Mgr. Marina Oseeva
PhD student abroad