Intranet

Fyziologický ústav AV ČR

Špičková věda pro zdraví

Biologické rytmy

Biologické rytmy Z leva: Centrální hodiny v mozku - suprachiasmatická jádra (SCN); gliové buňky v SCN; záznamy pohybové aktivity potkana - aktogramy; neurony v hipokampu; záznamy exprese hodinového genu v SCN a fázový graf.

V centru našeho zájmu je časový systém - biologické hodiny - savců včetně člověka. Tento systém zajišťuje časovou koordinaci fyziologických procesů v našem těle tak, aby probíhaly ve správnou denní dobu a byly vzájemně optimálně načasovány.

Porucha časové regulace má negativní dopad pro zdraví člověka. S využitím in vivo a in vitro modelů studujeme jak molekulární podstatu biologických hodin, tak i výsledné rytmy ve fyziologii a chování. Zabýváme se především otázkami:

  •  Jaký je mechanismus seřizování časového systému v těle a jaké jsou následky poruchy tohoto mechanismu?
  •  Jak se časový systém vyvíjí a jak je seřizován během ontogeneze?
  •  Jak je nastaven časový systém člověka v reálném životě, a to jak ve zdraví, tak i v nemoci?  

 

          

Fig. PER2 protein v SCN, 7-denní ex vivo mikroskopie.

 

Aktuální projekty

Ontogeneze cirkadiánního systému laboratorního potkana

Cirkadiánní hodiny savců se začínají vyvíjet již během embryonálního vývoje v děloze matky. Na svět přicházejí mláďata savců s hodinami, které jsou nastaveny tak, že běží v souladu s matčinými. Dlouhodobě se zaměřujeme na zkoumání kdy a jak se tyto hodiny vyvíjí a nastavují. Více

Úspěchy

Publikace

Sumová; Alena - Čečmanová; Vendula . Mystery of rhythmic signal emergence within the suprachiasmatic nuclei . European Journal of Neuroscience. 2020; 51(1); 300-309 . IF = 3.115 [ASEP] [ doi ]
Sládek; Martin - Röschová; Michaela - Adámková; V. - Hamplová; Dana - Sumová; Alena . Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe . Scientific Reports. 2020; 10(1)); 1419 . IF = 3.998 [ASEP] [ doi ]
Dodge; A. - Peters; M. M. - Greene; H. E. - Dietrick; C. - Botelho; R. - Chung; D. - Willman; J. - Nenninger; A. W. - Ciarlone; S. - Kamath; S. G. - Houdek; Pavel - Sumová; Alena - Anderson; A. E. - Dindot; S. V. - Berg; E. L. - O´Geeen; H. - Segal; D. J. - Silverman; J. L. - Weeber; E. J. - Nash; K. R. Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion . Autism Research. 2020; 13(3); 397-409 . IF = 3.727 [ASEP] [ doi ]
Sládek; Martin - Houdek; Pavel - Sumová; Alena . Circadian profiling reveals distinct regulation of endocannabinoid system in the rat plasma; liver and adrenal glands by light-dark and feeding cycles . Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2019; 1864(12)); 158533 . IF = 3.367 [ASEP] [ doi ]
Sládek, Martin - Sumová, Alena . Modulation of NMDA-Mediated Clock Resetting in the Suprachiasmatic Nuclei of mPer2(Luc) Mouse by Endocannabinoids . Frontiers in physiology 2019, 10(Mar 29)), 361 . IF = 4.519 [ASEP] [ doi ]
Čečmanová; Vendula - Houdek; Pavel - Šuchmanová; Karolína - Sládek; Martin - Sumová; Alena . Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids . Journal of Biological Rhythms. 2019; 34(3); 307-322 . IF = 3.122 [ASEP] [ doi ]
Shrestha, T. C. - Šuchmanová, Karolína - Houdek, Pavel - Sumová, Alena - Ralph, M. R. Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks . Scientific Reports 2018, 8(Oct 19)), 15547 . IF = 4.011 [ASEP] [ doi ]
Petrásek, Tomáš - Vojtěchová, Iveta - Lobellová, Veronika - Popelíková, Anna - Janíková, Martina - Brožka, Hana - Houdek, Pavel - Sládek, Martin - Sumová, Alena - Krištofíková, Z. - Valeš, Karel - Stuchlík, Aleš . The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity . Frontiers in Aging Neuroscience 2018, roč. 10, Aug 28, článku 250 . IF = 3.633 [ASEP] [ doi ]
Olejníková, Lucie - Polidarová, Lenka - Sumová, Alena . Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid‐dependent mechanism . Acta Physiologica 2018, roč. 223, 1, článku e13020 . IF = 5.868 [ASEP] [ doi ]
Olejníková, Lucie - Polidarová, Lenka - Behuliak, Michal - Sládek, Martin - Sumová, Alena . Circadian alignment in a foster mother improves the offspring's pathological phenotype . Journal of Physiology 2018, 596(23), 5757-5775 . IF = 4.950 [ASEP] [ doi ]
Novosadová, Zuzana - Polidarová, Lenka - Sládek, Martin - Sumová, Alena . Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2(Luc) mice . Scientific Reports 2018, roč. 8, Aug 3, článku 11668 . IF = 4.011 [ASEP] [ doi ]
Polidarová, Lenka - Sládek, Martin - Novosadová, Zuzana - Sumová, Alena . Aging does not compromise in vitro oscillation of the suprachiasmatic nuclei but makes it more vulnerable to constant light . Chronobiology International. 2017, roč. 34, 1, p. 105-117 . IF = 2.643 [ASEP] [ doi ]
Polidarová, Lenka - Houdek, Pavel - Sumová, Alena . Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon . Chronobiology International. 2017, roč. 34, 9, p. 1273-1287 . IF = 2.643 [ASEP] [ doi ]
Polidarová, Lenka - Houdek, Pavel - Sládek, Martin - Novosadová, Zuzana - Pácha, Jiří - Sumová, Alena . Mechanisms of hormonal regulation of the peripheral circadian clock in the colon . Chronobiology International. 2017, roč. 34, 1, p. 1-16 . IF = 2.643 [ASEP] [ doi ]
Májovský, M. - Řezáčová, Lenka - Sumová, Alena - Pospíšilová, L. - Netuka, D. - Bradáč, O. - Beneš, V. Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection . Journal of Clinical Neuroscience. 2017, roč. 39, May 2017, p. 155-163 . IF = 1.640 [ASEP] [ doi ]
Weissová, Kamila - Bartoš, A. - Sládek, Martin - Nováková, Marta - Sumová, Alena . Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment . PLoS ONE. 2016, roč. 11, 1, e0146200 . IF = 2.806 [ASEP] [ doi ]
Soták, Matúš - Bryndová, Jana - Ergang, Peter - Vagnerová, Karla - Kvapilová, Pavlína - Vodička, Martin - Pácha, Jiří - Sumová, Alena . Peripheral circadian clocks are diversely affected by adrenalectomy . Chronobiology International. 2016, roč. 33, 5, p. 520-529 . IF = 2.562 [ASEP] [ doi ]
Houdek, Pavel - Nováková, Marta - Polidarová, Lenka - Sládek, Martin - Sumová, Alena . Melatonin is a redundant entraining signal in the rat circadian system . Hormones and Behavior. 2016, roč. 83, Jul, p. 1-5 . IF = 3.378 [ASEP] [ doi ]
Olejníková, Lucie - Polidarová, Lenka - Paušlyová, Lucia - Sládek, Martin - Sumová, Alena . Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease . Chronobiology International. 2015, Vol. 32, 4, p. 531-547 . IF = 3.54 [ASEP] [ doi ]
Houdek, Pavel - Polidarová, Lenka - Nováková, Marta - Matějů, Kristýna - Kubík, Štěpán - Sumová, Alena . Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver . Developmental Neurobiology. 2015, Vol. 75, 2, p. 131-144 . IF = 2.529 [ASEP] [ doi ]
Nováková, Marta - Praško, J. - Látalová, K. - Sládek, Martin - Sumová, Alena . The circadian system of patients with bipolar disorder differs in episodes of mania and depression . Bipolar Disorders. 2015, Vol. 17, 3, p. 303-314 . IF = 4.882 [ASEP] [ doi ]
Soták, Matúš - Sumová, Alena - Pácha, Jiří . Cross-talk between the circadian clock and the cell cycle in cancer . Annals of Medicine 2014, roč. 46, 4, p. 221-232. ISSN 0785-3890. IF = 3.886 [ASEP] [ doi ]
Polidarová, Lenka - Olejníková, Lucie - Paušlyová, Lucia - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena . Development and entrainment of the colonic circadian clock during ontogenesis . American Journal of Physiology-Gastrointestinal and Liver Physiology 2014, roč. 306, 4, g346-g356. ISSN 0193-1857. IF = 3.798 [ASEP] [ doi ]
Petrásek, Tomáš - Prokopová, Iva - Sládek, Martin - Weissová, Kamila - Vojtěchová, Iveta - Bahník, Štěpán - Zemanová, Anna - Schönig, K. - Berger, S. - Tews, B. - Bartsch, D. - Schwab, M. E. - Sumová, Alena - Stuchlík, Aleš . Human osteoblast-like MG 63 cells on polysulfone modified with carbon nanotubes or carbon nanohorns . Frontiers in Behavioral Neuroscience 2014, roč. 8, mar 18, p. 90. ISSN 1662-5153. IF = 3.27 [ASEP] [ doi ]
Nováková, Marta - Sumová, Alena . New methods to assess circadian clocks in humans . INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY 2014, roč. 52, 5, p. 404-412. ISSN 0019-5189. IF = 0.835 [ASEP]
Houdek, Pavel - Sumová, Alena . In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei . PLoS ONE 2014, roč. 9, 9, e107360. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Bendová, Zdeňka - Janoušková, Hana - Svobodová, Irena . Circadian rhythm and photic induction of the C-terminal splice variant of NMDAR1 subunit in the rat suprachiasmatic nucleus . Synapse 2014, roč. 68, 2, p. 85-88. ISSN 0887-4476. IF = 2.127 [ASEP] [ doi ]
Zhang, L. - Hastings, M. H. - Green, E. W. - Tauber, E. - Sládek, Martin - Webster, S. G. - Kyriacou, C. P. - Wilcockson, D. C. Dissociation of Circadian and Circatidal Timekeeping in the Marine Crustacean Eurydice pulchra . Current Biology, 2013, Vol. 23, 19, p. 1863-1873 . IF = 9.494 [ASEP] [ doi ]
Soták, Matúš - Polidarová, Lenka - Ergang, Peter - Sumová, Alena - Pácha, Jiří . An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors . International Journal of Cancer, 2013, Vol. 132, 5, p. 1032-1041 . IF = 6.198 [ASEP] [ doi ]
Sládek, Martin - Sumová, Alena . Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles . PLoS ONE, 2013, Vol. 8, 10, e77010 . IF = 3.730 [ASEP] [ doi ]
Pácha, Jiří - Sumová, Alena . Circadian regulation of epithelial functions in the intestine . Acta Physiologica, 2013, Vol. 208, 1, p. 11-24 . IF = 4.382 [ASEP] [ doi ]
Polidarová, Lenka - Sládek, Martin - Nováková, Marta - Parkanová, Daniela - Sumová, Alena . Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver . PLoS ONE, 2013, Vol. 8, 9, e75690 . IF = 3.730 [ASEP] [ doi ]
Nováková, Marta - Sládek, Martin - Sumová, Alena . Human Chronotype Is Determined in Bodily Cells Under Real-Life Conditions . Chronobiology International, 2013, Vol. 30, 4, p. 607-617 . IF = 4.350 [ASEP] [ doi ]
Šanda, Pavel - Maršálek, P. Stochastic interpolation model of the medial superior olive neural circuit . Brain Research, 2012, Vol. 1434, JAN 24, p. 257-265 . IF = 2.879 [ASEP] [ doi ]
Sumová, Alena - Sládek, Martin - Polidarová, Lenka - Nováková, Marta - Houdek, Pavel . Circadian system from conception till adulthood . Progress in Brain Research, 2012, Vol. 199, 2012, p. 83-103 . IF = 4.191 [ASEP] [ doi ]
Sládek, Martin - Polidarová, Lenka - Nováková, Marta - Parkanová, Daniela - Sumová, Alena . Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats . PLoS ONE, 2012, Vol. 7, 10, e46951 . IF = 3.730 [ASEP] [ doi ]
Parkanová, Daniela - Nováková, Marta - Sosniyenko, Serhiy - Sumová, Alena . Photoperiodic modulation of the hepatic clock by the suprachiasmatic nucleus and feeding regime in mice . European Journal of Neuroscience, 2012, Vol. 35, 9, p. 1446-1457 . IF = 3.753 [ASEP] [ doi ]
Nováková, Marta - Nevšímalová, S. - Příhodová, I. - Sládek, Martin - Sumová, Alena . Alteration of the Circadian Clock in Children with Smith-Magenis Syndrome . Journal of Clinical Endocrinology and Metabolism, 2012, Vol. 97, 2, E312-E318 . IF = 6.430 [ASEP] [ doi ]
Bendová, Zdeňka - Sládek, Martin - Svobodová, Irena . The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation . Neurochemistry International, 2012, Vol. 61, 1, p. 43-47 . IF = 2.659 [ASEP] [ doi ]
Soták, Matúš - Polidarová, Lenka - Musílková, Jana - Hock, Miroslav - Sumová, Alena - Pácha, Jiří . Circadian regulation of electrolyte absorption in the rat colon . American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011, Vol. 301, 6, G1066-G1074 . IF = 3.431 [ASEP] [ doi ]
Polidarová, Lenka - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena . Hepatic, Duodenal, and Colonic Circadian Clocks Differ in their Persistence under Conditions of Constant Light and in their Entrainment by Restricted Feeding . Chronobiology International, 2011, Vol. 28, 3, p. 204-215 . IF = 4.028 [ASEP] [ doi ]
Nováková, Marta - Paclt, I. - Ptáček, R. - Kuželová, H. - Hájek, Ivan - Sumová, Alena . Salivary Melatonin Rhythm as a Marker of the Circadian System in Healthy Children and Those With Attention-Deficit/Hyperactivity Disorder . Chronobiology International, 2011, Vol. 28, 7, p. 630-637 . IF = 4.028 [ASEP] [ doi ]
Nováková, Marta - Polidarová, Lenka - Sládek, Martin - Sumová, Alena . Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light . Neuroscience, 2011, Vol. 197, -, p. 65-71 . IF = 3.380 [ASEP] [ doi ]
Sosniyenko, Serhiy - Parkanová, Daniela - Illnerová, Helena - Sládek, Martin - Sumová, Alena . Different mechanisms of adjustment to a change of the photoperiod in the suprachiasmatic and liver circadian clocks . American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2010, Vol. 298, 4, R959-R971 . IF = 3.284 [ASEP] [ doi ]
Nováková, Marta - Sládek, Martin - Sumová, Alena . Exposure of Pregnant Rats to Restricted Feeding Schedule Synchronizes the SCN Clocks of Their Fetuses under Constant Light but Not under a Light-Dark Regime . Journal of Biological Rhythms, 2010, Vol. 25, 5, p. 350-360 . IF = 3.309 [ASEP] [ doi ]
Matějů, Kristýna - Sumová, Alena - Bendová, Zdeňka . Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats . Journal of Comparative Neurology, 2010, Vol. 518, 17, p. 3630-3644 . IF = 3.774 [ASEP] [ doi ]
Zíková, Martina - Corlett, Alicia - Bendová, Zdeňka - Pajer, Petr - Bartůněk, Petr . DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism . Molecular Endocrinology, 2009, Vol. 23, 4, p. 520-528 . IF = 5.257 [ASEP] [ doi ]
Walton, K. M. - Fisher, K. - Rubitski, D. - Marconi, M. - Meng, Q.-J. - Sládek, Martin - Adams, J. - Bass, M. - Chandrasekaran, R. - Butler, T. - Griffor, M. - Rajamohan, F. - Serpa, M. - Chen, Y. - Claffey, M. - Hastings, M. - Loudon, A. - Maywood, E. - . Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period . Journal of Pharmacology and Experimental Therapeutics, 2009, Vol. 330, 2, p. 430-439 . IF = 4.093 [ASEP] [ doi ]
Sosniyenko, Serhiy - Hut, R.A. - Daan, S. - Sumová, Alena . Influence of photoperiod duration and light–dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus . European Journal of Neuroscience, 2009, Vol. 30, 9, p. 1802-1814 . IF = 3.418 [ASEP] [ doi ]
Polidarová, Lenka - Soták, Matúš - Sládek, Martin - Pácha, Jiří - Sumová, Alena . Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint Kinase Wee1 Expression along the Gut . Chronobiology International, 2009, Vol. 26, 4, p. 607-620 . IF = 3.987 [ASEP] [ doi ]
Matějů, Kristýna - Bendová, Zdena - El-Hennamy, Rehab - Sládek, Martin - Sosniyenko, Serhiy - Sumová, Alena . Development of the light sensitivity of the clock genes Period1 and Period2, and immediate-early gene c-fos within the rat suprachiasmatic nucleus . European Journal of Neuroscience, 2009, Vol. 29, 3, p. 490-501 . IF = 3.418 [ASEP] [ doi ]
Bendová, Zdeňka - Sumová, Alena - Mikkelsen, J. D. Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus . Neuroscience, 2009, Vol. 159, 2, p. 599-609 . IF = 3.292 [ASEP] [ doi ]
Sumová, Alena - Bendová, Zdeňka - Sládek, Martin - El-Hennamy, Rehab - Matějů, Kristýna - Polidarová, Lenka - Sosniyenko, Serhiy - Illnerová, Helena . Circadian molecular clocks tick along ontogenesis . Physiological Research, 2008, Vol. 57, Suppl.3, S139-S148 . IF = 1.653 [ASEP]
El-Hennamy, Rehab - Matějů, Kristýna - Bendová, Zdena - Sosniyenko, Serhiy - Sumová, Alena . Maternal Control of the Fetal and Neonatal Rat Suprachiasmatic Nucleus . Journal of Biological Rhythms, 2008, Vol. 23, 5, p. 435-444 . IF = 4.211 [ASEP] [ doi ]
Blažejová, K. - Illnerová, Helena - Hájek, Ivan - Nevšímalová, S. Circadian rhythm in salivary melatonin in narcoleptic patiens . Neuroscience Letters, 2008, Vol. 437, 2, p. 162-164 . IF = 2.200 [ASEP] [ doi ]
Sumová, Alena - Kováčiková, Zuzana - Illnerová, Helena . Dynamics of the Adjustment of Clock Gene Expression in the Rat Suprachiasmatic Nucleus to an Asymmetrical Change from a Long to a Short Photoperiod . Journal of Biological Rhythms, 2007, Vol. 22, 3, p. 259-267 . IF = 3.868 [ASEP]
Sládek, Martin - Jindráková, Zuzana - Bendová, Zdeňka - Sumová, Alena . Postnatal ontogenesis of the circadian clock within the rat liver . American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2007, Vol. 292, 3, R1224-R1229 . IF = 3.661 [ASEP]
Sládek, Martin - Rybová, Markéta - Jindráková, Zuzana - Zemanová, Zdeňka - Polidarová, Lenka - Mrnka, Libor - O´Neill, J. - Pácha, Jiří - Sumová, Alena . Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells . Gastroenterology, 2007, Vol. 133, 4, p. 1240-1249 . IF = 11.673 [ASEP]

Fotogalerie oddělení

Celá fotogalerie

Lidé

Doc. PharmDr. Alena Sumová, DSc.

vedoucí oddělení

Mgr. Martin Sládek, PhD.

zástupce vedoucího 

Prof. RNDr. Helena Illnerová, DrSc.

emeritní profesor

Mgr. Lenka Polidarová, PhD.

postdoc na mateřské

RNDr. Pavel Houdek

vědecký asistent

Mgr. Petra Honzlová

postgraduální student

MMed. Kateryna Semenovykh

postgraduální student

Mgr. Milica Drapšin

postgraduální student

         

MSc. Philipp Greiner 

postgraduální student

 

Michaela Kudrnáčová

postgraduální student

Eva Suchanová

technický pracovník